| 1 | Thu Oct 14 | vs Lightning | L6-7 (OT) | 0-0-1 | 1 PTS | Little Caesars Arena · Detroit, MI |
| 2 | Sat Oct 16 | vsCanucks | W3-1 | 1-0-1 | 3 PTS | Little Caesars Arena · Detroit, MI |
| 3 | Tue Oct 19 | vsJackets | W4-1 | 2-0-1 | 5 PTS | Little Caesars Arena · Detroit, MI |
| 4 | Thu Oct 21 | vsFlames | L0-3 | 2-1-1 | 5 PTS | Little Caesars Arena · Detroit, MI |
| 5 | Sat Oct 23 | atCanadiens | L1-6 | 2-2-1 | 5 PTS | Bell Centre · Montreal, QC |
| 6 | Sun Oct 24 | atBlackhawks | W6-3 | 3-2-1 | 7 PTS | United Center · Chicago, IL |
| 7 | Wed Oct 27 | atCapitals | W3-2 (OT) | 4-2-1 | 9 PTS | Capital One Arena · Washington, D.C. |
| 8 | Fri Oct 29 | vsPanthers | L2-3 (OT) | 4-2-2 | 10 PTS | Little Caesars Arena · Detroit, MI |
| 9 | Sat Oct 30 | atMaple Leafs | L4-5 | 4-3-2 | 10 PTS | Scotiabank Arena · Toronto, ON |
| 10 | Tue Nov 2 | atCanadiens | L0-3 | 4-4-2 | 10 PTS | Bell Centre · Montreal, QC |
| 11 | Thu Nov 4 | atBruins | L1-5 | 4-5-2 | 10 PTS | TD Garden · Boston, MA |
| 12 | Sat Nov 6 | atSabres | W4-3 (OT) | 5-5-2 | 12 PTS | KeyBank Center · Buffalo, NY |
| 13 | Sun Nov 7 | vsKnights | W5-2 | 6-5-2 | 14 PTS | Little Caesars Arena · Detroit, MI |
| 14 | Tue Nov 9 | vsOilers | W4-2 | 7-5-2 | 16 PTS | Little Caesars Arena · Detroit, MI |
| 15 | Thu Nov 11 | vsCapitals | L0-2 | 7-6-2 | 16 PTS | Little Caesars Arena · Detroit, MI |
| 16 | Sat Nov 13 | vsCanadiens | W3-2 (OT) | 8-6-2 | 18 PTS | Little Caesars Arena · Detroit, MI |
| 17 | Mon Nov 15 | atJackets | L3-5 | 8-7-2 | 18 PTS | Nationwide Arena · Columbus, OH |
| 18 | Tue Nov 16 | atStars | L2-5 | 8-8-2 | 18 PTS | American Airlines Center · Dallas, TX |
| 19 | Thu Nov 18 | atKnights | L2-5 | 8-9-2 | 18 PTS | T-Mobile Arena · Las Vegas, NV |
| 20 | Sat Nov 20 | atCoyotes | L1-2 (OT) | 8-9-3 | 19 PTS | Mullett Arena · Tempe, AZ |
| 21 | Wed Nov 24 | vsBlues | W4-2 | 9-9-3 | 21 PTS | Little Caesars Arena · Detroit, MI |
| 22 | Sat Nov 27 | vsSabres | W3-2 (OT) | 10-9-3 | 23 PTS | Little Caesars Arena · Detroit, MI |
| 23 | Tue Nov 30 | atBruins | W2-1 | 11-9-3 | 25 PTS | TD Garden · Boston, MA |
| 24 | Wed Dec 1 | vsKraken | W4-3 (SO) | 12-9-3 | 27 PTS | Little Caesars Arena · Detroit, MI |
| 25 | Sat Dec 4 | vsIslanders | W4-3 (OT) | 13-9-3 | 29 PTS | Little Caesars Arena · Detroit, MI |
| 26 | Tue Dec 7 | vsPredators | L2-5 | 13-10-3 | 29 PTS | Little Caesars Arena · Detroit, MI |
| 27 | Thu Dec 9 | atBlues | L2-6 | 13-11-3 | 29 PTS | Enterprise Center · St. Louis, MO |
| 28 | Fri Dec 10 | atAvalanche | L3-7 | 13-12-3 | 29 PTS | Ball Arena · Denver, CO |
| 29 | Tue Dec 14 | vsIslanders | W2-1 | 14-12-3 | 31 PTS | Little Caesars Arena · Detroit, MI |
| 30 | Thu Dec 16 | atHurricanes | L3-5 | 14-13-3 | 31 PTS | PNC Arena · Raleigh, NC |
| 31 | Sat Dec 18 | vsDevils | W5-2 | 15-13-3 | 33 PTS | Little Caesars Arena · Detroit, MI |
| 32 | Fri Dec 31 | vsCapitals | L1-3 | 15-14-3 | 33 PTS | Little Caesars Arena · Detroit, MI |
| 33 | Sun Jan 2 | vsBruins | L1-5 | 15-15-3 | 33 PTS | Little Caesars Arena · Detroit, MI |
| 34 | Tue Jan 4 | vsSharks | W6-2 | 16-15-3 | 35 PTS | Little Caesars Arena · Detroit, MI |
| 35 | Sat Jan 8 | atKings | L0-4 | 16-16-3 | 35 PTS | Crypto.com Arena · Los Angeles, CA |
| 36 | Sun Jan 9 | atDucks | L3-4 (SO) | 16-16-4 | 36 PTS | Honda Center · Anaheim, CA |
| 37 | Tue Jan 11 | atSharks | L2-3 (OT) | 16-16-5 | 37 PTS | SAP Center · San Jose, CA |
| 38 | Thu Jan 13 | vsJets | L0-3 | 16-17-5 | 37 PTS | Little Caesars Arena · Detroit, MI |
| 39 | Sat Jan 15 | vsSabres | W4-0 | 17-17-5 | 39 PTS | Little Caesars Arena · Detroit, MI |
| 40 | Mon Jan 17 | atSabres | W3-2 (OT) | 18-17-5 | 41 PTS | KeyBank Center · Buffalo, NY |
| 41 | Fri Jan 21 | vsStars | L4-5 (OT) | 18-17-6 | 42 PTS | Little Caesars Arena · Detroit, MI |
| 42 | Sat Jan 22 | atPredators | L1-4 | 18-18-6 | 42 PTS | Bridgestone Arena · Nashville, TN |
| 43 | Wed Jan 26 | vsBlackhawks | L5-8 | 18-19-6 | 42 PTS | Little Caesars Arena · Detroit, MI |
| 44 | Fri Jan 28 | atPenguins | W3-2 (SO) | 19-19-6 | 44 PTS | PPG Paints Arena · Pittsburgh, PA |
| 45 | Sat Jan 29 | vsMaple Leafs | L4-7 | 19-20-6 | 44 PTS | Little Caesars Arena · Detroit, MI |
| 46 | Mon Jan 31 | vsDucks | W2-1 (OT) | 20-20-6 | 46 PTS | Little Caesars Arena · Detroit, MI |
| 47 | Wed Feb 2 | vsKings | L3-5 | 20-21-6 | 46 PTS | Little Caesars Arena · Detroit, MI |
| 48 | Wed Feb 9 | atFlyers | W6-3 | 21-21-6 | 48 PTS | Wells Fargo Center · Philadelphia, PA |
| 49 | Sat Feb 12 | vsFlyers | W4-2 | 22-21-6 | 50 PTS | Little Caesars Arena · Detroit, MI |
| 50 | Mon Feb 14 | atWild | L4-7 | 22-22-6 | 50 PTS | Xcel Energy Center · St. Paul, MN |
| 51 | Thu Feb 17 | atRangers | W3-2 (SO) | 23-22-6 | 52 PTS | Madison Square Garden · Manhattan, NY |
| 52 | Wed Feb 23 | vsAvalanche | L2-5 | 23-23-6 | 52 PTS | Little Caesars Arena · Detroit, MI |
| 53 | Sat Feb 26 | vsMaple Leafs | L7-10 | 23-24-6 | 52 PTS | Little Caesars Arena · Detroit, MI |
| 54 | Tue Mar 1 | vsHurricanes | W4-3 (OT) | 24-24-6 | 54 PTS | Little Caesars Arena · Detroit, MI |
| 55 | Fri Mar 4 | atLightning | L1-3 | 24-25-6 | 54 PTS | AMALIE Arena · Tampa, FL |
| 56 | Sat Mar 5 | atPanthers | L2-6 | 24-26-6 | 54 PTS | Amerant Bank Arena · Sunrise, FL |
| 57 | Tue Mar 8 | vsCoyotes | L2-9 | 24-27-6 | 54 PTS | Little Caesars Arena · Detroit, MI |
| 58 | Thu Mar 10 | vsWild | L5-6 (SO) | 24-27-7 | 55 PTS | Little Caesars Arena · Detroit, MI |
| 59 | Sat Mar 12 | atFlames | L0-3 | 24-28-7 | 55 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 60 | Tue Mar 15 | atOilers | L5-7 | 24-29-7 | 55 PTS | Rogers Place · Edmonton, AB |
| 61 | Thu Mar 17 | atCanucks | W1-0 | 25-29-7 | 57 PTS | Rogers Arena · Vancouver, British Columbia |
| 62 | Sat Mar 19 | atKraken | L2-4 | 25-30-7 | 57 PTS | Climate Pledge Arena · Seattle, WA |
| 63 | Tue Mar 22 | vsFlyers | W6-3 | 26-30-7 | 59 PTS | Little Caesars Arena · Detroit, MI |
| 64 | Thu Mar 24 | atIslanders | L2-5 | 26-31-7 | 59 PTS | UBS Arena · Elmont, NY |
| 65 | Sat Mar 26 | vsLightning | L1-2 (OT) | 26-31-8 | 60 PTS | Little Caesars Arena · Detroit, MI |
| 66 | Sun Mar 27 | atPenguins | L2-11 | 26-32-8 | 60 PTS | PPG Paints Arena · Pittsburgh, PA |
| 67 | Wed Mar 30 | vsRangers | L4-5 (OT) | 26-32-9 | 61 PTS | Little Caesars Arena · Detroit, MI |
| 68 | Fri Apr 1 | vsSenators | L2-5 | 26-33-9 | 61 PTS | Little Caesars Arena · Detroit, MI |
| 69 | Sun Apr 3 | atSenators | L2-5 | 26-34-9 | 61 PTS | Canadian Tire Centre · Ottawa, ON |
| 70 | Tue Apr 5 | vsBruins | W5-3 | 27-34-9 | 63 PTS | Little Caesars Arena · Detroit, MI |
| 71 | Wed Apr 6 | atJets | W3-1 | 28-34-9 | 65 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 72 | Sat Apr 9 | vsJackets | L4-5 (OT) | 28-34-10 | 66 PTS | Little Caesars Arena · Detroit, MI |
| 73 | Tue Apr 12 | vsSenators | L1-4 | 28-35-10 | 66 PTS | Little Caesars Arena · Detroit, MI |
| 74 | Thu Apr 14 | atHurricanes | W3-0 | 29-35-10 | 68 PTS | PNC Arena · Raleigh, NC |
| 75 | Sat Apr 16 | atRangers | L0-4 | 29-36-10 | 68 PTS | Madison Square Garden · Manhattan, NY |
| 76 | Sun Apr 17 | vsPanthers | L1-6 | 29-37-10 | 68 PTS | Little Caesars Arena · Detroit, MI |
| 77 | Tue Apr 19 | atLightning | W4-3 | 30-37-10 | 70 PTS | AMALIE Arena · Tampa, FL |
| 78 | Thu Apr 21 | atPanthers | L2-5 | 30-38-10 | 70 PTS | Amerant Bank Arena · Sunrise, FL |
| 79 | Sat Apr 23 | vsPenguins | L2-7 | 30-39-10 | 70 PTS | Little Caesars Arena · Detroit, MI |
| 80 | Sun Apr 24 | atDevils | W3-0 | 31-39-10 | 72 PTS | Prudential Center · Newark, NJ |
| 81 | Tue Apr 26 | atMaple Leafs | L0-3 | 31-40-10 | 72 PTS | Scotiabank Arena · Toronto, ON |
| 82 | Fri Apr 29 | atDevils | W5-3 | 32-40-10 | 74 PTS | Prudential Center · Newark, NJ |
