| 1 | Thu Jan 14 | vs Jackets | W3-1 | 1-0-0 | 2 PTS | Bridgestone Arena · Nashville, TN |
| 2 | Sat Jan 16 | vsJackets | W5-2 | 2-0-0 | 4 PTS | Bridgestone Arena · Nashville, TN |
| 3 | Mon Jan 18 | vsHurricanes | L2-4 | 2-1-0 | 4 PTS | Bridgestone Arena · Nashville, TN |
| 4 | Fri Jan 22 | atStars | L0-7 | 2-2-0 | 4 PTS | American Airlines Center · Dallas, TX |
| 5 | Sun Jan 24 | atStars | L2-3 | 2-3-0 | 4 PTS | American Airlines Center · Dallas, TX |
| 6 | Tue Jan 26 | vsBlackhawks | W3-2 (OT) | 3-3-0 | 6 PTS | Bridgestone Arena · Nashville, TN |
| 7 | Wed Jan 27 | vsBlackhawks | W2-1 (SO) | 4-3-0 | 8 PTS | Bridgestone Arena · Nashville, TN |
| 8 | Sat Jan 30 | atLightning | L3-4 | 4-4-0 | 8 PTS | AMALIE Arena · Tampa, FL |
| 9 | Mon Feb 1 | atLightning | L2-5 | 4-5-0 | 8 PTS | AMALIE Arena · Tampa, FL |
| 10 | Thu Feb 4 | atPanthers | W6-5 (OT) | 5-5-0 | 10 PTS | Amerant Bank Arena · Sunrise, FL |
| 11 | Fri Feb 5 | atPanthers | L1-2 | 5-6-0 | 10 PTS | Amerant Bank Arena · Sunrise, FL |
| 12 | Mon Feb 8 | vsLightning | L1-4 | 5-7-0 | 10 PTS | Bridgestone Arena · Nashville, TN |
| 13 | Tue Feb 9 | vsLightning | L1-6 | 5-8-0 | 10 PTS | Bridgestone Arena · Nashville, TN |
| 14 | Thu Feb 11 | vsRed Wings | W3-2 | 6-8-0 | 12 PTS | Bridgestone Arena · Nashville, TN |
| 15 | Sat Feb 13 | vsRed Wings | L2-4 | 6-9-0 | 12 PTS | Bridgestone Arena · Nashville, TN |
| 16 | Thu Feb 18 | atJackets | L0-3 | 6-10-0 | 12 PTS | Nationwide Arena · Columbus, OH |
| 17 | Sat Feb 20 | atJackets | W4-2 | 7-10-0 | 14 PTS | Nationwide Arena · Columbus, OH |
| 18 | Tue Feb 23 | atRed Wings | W2-0 | 8-10-0 | 16 PTS | Little Caesars Arena · Detroit, MI |
| 19 | Thu Feb 25 | atRed Wings | L2-5 | 8-11-0 | 16 PTS | Little Caesars Arena · Detroit, MI |
| 20 | Sat Feb 27 | vsJackets | W2-1 | 9-11-0 | 18 PTS | Bridgestone Arena · Nashville, TN |
| 21 | Sun Feb 28 | vsJackets | W3-1 | 10-11-0 | 20 PTS | Bridgestone Arena · Nashville, TN |
| 22 | Tue Mar 2 | vsHurricanes | L2-4 | 10-12-0 | 20 PTS | Bridgestone Arena · Nashville, TN |
| 23 | Thu Mar 4 | vsPanthers | L4-5 | 10-13-0 | 20 PTS | Bridgestone Arena · Nashville, TN |
| 24 | Sat Mar 6 | vsPanthers | L2-6 | 10-14-0 | 20 PTS | Bridgestone Arena · Nashville, TN |
| 25 | Sun Mar 7 | atStars | W4-3 (SO) | 11-14-0 | 22 PTS | American Airlines Center · Dallas, TX |
| 26 | Tue Mar 9 | atHurricanes | L2-3 (OT) | 11-14-1 | 23 PTS | PNC Arena · Raleigh, NC |
| 27 | Thu Mar 11 | atHurricanes | L1-5 | 11-15-1 | 23 PTS | PNC Arena · Raleigh, NC |
| 28 | Sat Mar 13 | atLightning | L3-6 | 11-16-1 | 23 PTS | AMALIE Arena · Tampa, FL |
| 29 | Mon Mar 15 | atLightning | W4-1 | 12-16-1 | 25 PTS | AMALIE Arena · Tampa, FL |
| 30 | Thu Mar 18 | atPanthers | W2-1 | 13-16-1 | 27 PTS | Amerant Bank Arena · Sunrise, FL |
| 31 | Sat Mar 20 | atPanthers | L0-2 | 13-17-1 | 27 PTS | Amerant Bank Arena · Sunrise, FL |
| 32 | Sun Mar 21 | atStars | W4-3 (SO) | 14-17-1 | 29 PTS | American Airlines Center · Dallas, TX |
| 33 | Tue Mar 23 | vsRed Wings | W2-0 | 15-17-1 | 31 PTS | Bridgestone Arena · Nashville, TN |
| 34 | Thu Mar 25 | vsRed Wings | W7-1 | 16-17-1 | 33 PTS | Bridgestone Arena · Nashville, TN |
| 35 | Sat Mar 27 | atBlackhawks | W3-1 | 17-17-1 | 35 PTS | United Center · Chicago, IL |
| 36 | Sun Mar 28 | atBlackhawks | W3-2 | 18-17-1 | 37 PTS | United Center · Chicago, IL |
| 37 | Tue Mar 30 | vsStars | W3-2 (OT) | 19-17-1 | 39 PTS | Bridgestone Arena · Nashville, TN |
| 38 | Thu Apr 1 | vsStars | L1-4 | 19-18-1 | 39 PTS | Bridgestone Arena · Nashville, TN |
| 39 | Sat Apr 3 | vsBlackhawks | W3-0 | 20-18-1 | 41 PTS | Bridgestone Arena · Nashville, TN |
| 40 | Tue Apr 6 | atRed Wings | W3-2 (SO) | 21-18-1 | 43 PTS | Little Caesars Arena · Detroit, MI |
| 41 | Thu Apr 8 | atRed Wings | W7-1 | 22-18-1 | 45 PTS | Little Caesars Arena · Detroit, MI |
| 42 | Sat Apr 10 | vsLightning | L0-3 | 22-19-1 | 45 PTS | Bridgestone Arena · Nashville, TN |
| 43 | Sun Apr 11 | vsStars | W3-2 (SO) | 23-19-1 | 47 PTS | Bridgestone Arena · Nashville, TN |
| 44 | Tue Apr 13 | vsLightning | W7-2 | 24-19-1 | 49 PTS | Bridgestone Arena · Nashville, TN |
| 45 | Thu Apr 15 | atHurricanes | L1-4 | 24-20-1 | 49 PTS | PNC Arena · Raleigh, NC |
| 46 | Sat Apr 17 | atHurricanes | L1-3 | 24-21-1 | 49 PTS | PNC Arena · Raleigh, NC |
| 47 | Mon Apr 19 | vsBlackhawks | W5-2 | 25-21-1 | 51 PTS | Bridgestone Arena · Nashville, TN |
| 48 | Wed Apr 21 | atBlackhawks | L4-5 (OT) | 25-21-2 | 52 PTS | United Center · Chicago, IL |
| 49 | Fri Apr 23 | atBlackhawks | W3-1 | 26-21-2 | 54 PTS | United Center · Chicago, IL |
| 50 | Mon Apr 26 | vsPanthers | W4-1 | 27-21-2 | 56 PTS | Bridgestone Arena · Nashville, TN |
| 51 | Tue Apr 27 | vsPanthers | L4-7 | 27-22-2 | 56 PTS | Bridgestone Arena · Nashville, TN |
| 52 | Sat May 1 | vsStars | W1-0 (OT) | 28-22-2 | 58 PTS | Bridgestone Arena · Nashville, TN |
| 53 | Mon May 3 | atJackets | W4-3 (OT) | 29-22-2 | 60 PTS | Nationwide Arena · Columbus, OH |
| 54 | Wed May 5 | atJackets | L2-4 | 29-23-2 | 60 PTS | Nationwide Arena · Columbus, OH |
| 55 | Sat May 8 | vsHurricanes | W3-1 | 30-23-2 | 62 PTS | Bridgestone Arena · Nashville, TN |
| 56 | Mon May 10 | vsHurricanes | W5-0 | 31-23-2 | 64 PTS | Bridgestone Arena · Nashville, TN |
| 1 | Mon May 17 | atHurricanes | L2-5 | 0-1 | .000 | PNC Arena · Raleigh, NC |
| 2 | Wed May 19 | atHurricanes | L0-3 | 0-2 | .000 | PNC Arena · Raleigh, NC |
| 3 | Fri May 21 | vsHurricanes | W5-4 (OT) | 1-2 | .333 | Bridgestone Arena · Nashville, TN |
| 4 | Sun May 23 | vsHurricanes | W4-3 (OT) | 2-2 | .500 | Bridgestone Arena · Nashville, TN |
| 5 | Tue May 25 | atHurricanes | L2-3 (OT) | 2-3 | .400 | PNC Arena · Raleigh, NC |
| 6 | Thu May 27 | vsHurricanes | L3-4 (OT) | 2-4 | .333 | Bridgestone Arena · Nashville, TN |
