| 1 | Thu Oct 10 | vs Stars | L3-4 | 0-1-0 | 0 PTS | Bridgestone Arena · Nashville, TN |
| 2 | Sat Oct 12 | at Red Wings | L0-3 | 0-2-0 | 0 PTS | Little Caesars Arena · Detroit, MI |
| 3 | Tue Oct 15 | vs Kraken | L3-7 | 0-3-0 | 0 PTS | Bridgestone Arena · Nashville, TN |
| 4 | Thu Oct 17 | vs Oilers | L2-4 | 0-4-0 | 0 PTS | Bridgestone Arena · Nashville, TN |
| 5 | Sat Oct 19 | vsRed Wings | L2-5 | 0-5-0 | 0 PTS | Bridgestone Arena · Nashville, TN |
| 6 | Tue Oct 22 | vs Bruins | W4-0 | 1-5-0 | 2 PTS | Bridgestone Arena · Nashville, TN |
| 7 | Fri Oct 25 | at Blackhawks | W3-2 | 2-5-0 | 4 PTS | United Center · Chicago, IL |
| 8 | Sat Oct 26 | vs Jackets | W4-3 (OT) | 3-5-0 | 6 PTS | Bridgestone Arena · Nashville, TN |
| 9 | Mon Oct 28 | at Lightning | L2-3 (OT) | 3-5-1 | 7 PTS | AMALIE Arena · Tampa, FL |
| 10 | Thu Oct 31 | vsOilers | L1-5 | 3-6-1 | 7 PTS | Bridgestone Arena · Nashville, TN |
| 11 | Sat Nov 2 | vs Avalanche | W5-2 | 4-6-1 | 9 PTS | Bridgestone Arena · Nashville, TN |
| 12 | Mon Nov 4 | vs Kings | L0-3 | 4-7-1 | 9 PTS | Bridgestone Arena · Nashville, TN |
| 13 | Wed Nov 6 | at Capitals | L2-3 | 4-8-1 | 9 PTS | Capital One Arena · Washington, D.C. |
| 14 | Thu Nov 7 | at Panthers | L2-6 | 4-9-1 | 9 PTS | Amerant Bank Arena · Sunrise, FL |
| 15 | Sat Nov 9 | vs Utah HC | W4-0 | 5-9-1 | 11 PTS | Bridgestone Arena · Nashville, TN |
| 16 | Mon Nov 11 | atAvalanche | L2-3 (OT) | 5-9-2 | 12 PTS | Ball Arena · Denver, CO |
| 17 | Thu Nov 14 | atOilers | L2-3 (OT) | 5-9-3 | 13 PTS | Rogers Place · Edmonton, AB |
| 18 | Fri Nov 15 | at Flames | L0-2 | 5-10-3 | 13 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 19 | Sun Nov 17 | at Canucks | W5-3 | 6-10-3 | 15 PTS | Rogers Arena · Vancouver, British Columbia |
| 20 | Wed Nov 20 | atKraken | L0-3 | 6-11-3 | 15 PTS | Climate Pledge Arena · Seattle, WA |
| 21 | Sat Nov 23 | vs Jets | W4-1 | 7-11-3 | 17 PTS | Bridgestone Arena · Nashville, TN |
| 22 | Mon Nov 25 | at Devils | L2-5 | 7-12-3 | 17 PTS | Prudential Center · Newark, NJ |
| 23 | Wed Nov 27 | vs Flyers | L2-3 (OT) | 7-12-4 | 18 PTS | Bridgestone Arena · Nashville, TN |
| 24 | Fri Nov 29 | vsLightning | L2-3 (OT) | 7-12-5 | 19 PTS | Bridgestone Arena · Nashville, TN |
| 25 | Sat Nov 30 | at Wild | L2-3 (OT) | 7-12-6 | 20 PTS | Xcel Energy Center · St. Paul, MN |
| 26 | Wed Dec 4 | at Maple Leafs | L2-3 | 7-13-6 | 20 PTS | Scotiabank Arena · Toronto, ON |
| 27 | Thu Dec 5 | at Canadiens | L0-3 | 7-14-6 | 20 PTS | Bell Centre · Montreal, QC |
| 28 | Sat Dec 7 | at Senators | L1-3 | 7-15-6 | 20 PTS | Canadian Tire Centre · Ottawa, ON |
| 29 | Tue Dec 10 | vsFlames | L3-4 | 7-16-6 | 20 PTS | Bridgestone Arena · Nashville, TN |
| 30 | Thu Dec 12 | atStars | W4-1 | 8-16-6 | 22 PTS | American Airlines Center · Dallas, TX |
| 31 | Sat Dec 14 | atAvalanche | L2-5 | 8-17-6 | 22 PTS | Ball Arena · Denver, CO |
| 32 | Tue Dec 17 | vs Rangers | W2-0 | 9-17-6 | 24 PTS | Bridgestone Arena · Nashville, TN |
| 33 | Thu Dec 19 | vs Penguins | L4-5 (OT) | 9-17-7 | 25 PTS | Bridgestone Arena · Nashville, TN |
| 34 | Sat Dec 21 | vsKings | W3-2 (OT) | 10-17-7 | 27 PTS | Bridgestone Arena · Nashville, TN |
| 35 | Mon Dec 23 | vs Hurricanes | W5-2 | 11-17-7 | 29 PTS | Bridgestone Arena · Nashville, TN |
| 36 | Fri Dec 27 | at Blues | L4-7 | 11-18-7 | 29 PTS | Enterprise Center · St. Louis, MO |
| 37 | Mon Dec 30 | atJets | L0-3 | 11-19-7 | 29 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 38 | Tue Dec 31 | atWild | L3-5 | 11-20-7 | 29 PTS | Xcel Energy Center · St. Paul, MN |
| 39 | Fri Jan 3 | atCanucks | W3-0 | 12-20-7 | 31 PTS | Rogers Arena · Vancouver, British Columbia |
| 40 | Sat Jan 4 | atFlames | W4-1 | 13-20-7 | 33 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 41 | Tue Jan 7 | atJets | L2-5 | 13-21-7 | 33 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 42 | Sat Jan 11 | vsCapitals | L1-4 | 13-22-7 | 33 PTS | Bridgestone Arena · Nashville, TN |
| 43 | Tue Jan 14 | vs Knights | W5-3 | 14-22-7 | 35 PTS | Bridgestone Arena · Nashville, TN |
| 44 | Thu Jan 16 | vsBlackhawks | W3-2 (SO) | 15-22-7 | 37 PTS | Bridgestone Arena · Nashville, TN |
| 45 | Sat Jan 18 | vsWild | W6-2 | 16-22-7 | 39 PTS | Bridgestone Arena · Nashville, TN |
| 46 | Tue Jan 21 | vs Sharks | W7-5 | 17-22-7 | 41 PTS | Bridgestone Arena · Nashville, TN |
| 47 | Thu Jan 23 | atSharks | W6-5 | 18-22-7 | 43 PTS | SAP Center · San Jose, CA |
| 48 | Sat Jan 25 | at Ducks | L2-5 | 18-23-7 | 43 PTS | Honda Center · Anaheim, CA |
| 49 | Wed Jan 29 | vsCanucks | L1-3 | 18-24-7 | 43 PTS | Bridgestone Arena · Nashville, TN |
| 50 | Fri Jan 31 | at Sabres | L3-4 | 18-25-7 | 43 PTS | KeyBank Center · Buffalo, NY |
| 51 | Sat Feb 1 | atPenguins | L0-3 | 18-26-7 | 43 PTS | PPG Paints Arena · Pittsburgh, PA |
| 52 | Mon Feb 3 | vsSenators | L2-5 | 18-27-7 | 43 PTS | Bridgestone Arena · Nashville, TN |
| 53 | Fri Feb 7 | atBlackhawks | L2-6 | 18-28-7 | 43 PTS | United Center · Chicago, IL |
| 54 | Sat Feb 8 | vsSabres | W6-4 | 19-28-7 | 45 PTS | Bridgestone Arena · Nashville, TN |
Islanders