| 1 | Thu Aug 29 | vs Albany | W38-21 | 1-0 | 1.000 | Kelly/Shorts Stadium · Mount Pleasant, MI |
| 2 | Sat Sep 7 | at#17Wisconsin | L0-61 | 1-1 | .500 | Camp Randall Stadium · Madison, WI |
| 3 | Sat Sep 14 | vsAkron | W45-24 | 2-1 | .667 | Kelly/Shorts Stadium · Mount Pleasant, MI |
| 4 | Sat Sep 21 | atMiami | L12-17 | 2-2 | .500 | Hard Rock Stadium · Miami Gardens, FL |
| 5 | Sat Sep 28 | atW Michigan | L15-31 | 2-3 | .400 | Waldo Stadium · Kalamazoo, MI |
| 6 | Sat Oct 5 | vsE Michigan | W42-16 | 3-3 | .500 | Kelly/Shorts Stadium · Mount Pleasant, MI |
| 7 | Sat Oct 12 | vsNew Mexico St | W42-28 | 4-3 | .571 | Kelly/Shorts Stadium · Mount Pleasant, MI |
| 8 | Sat Oct 19 | atBowling Green | W38-20 | 5-3 | .625 | Doyt L. Perry Stadium · Bowling Green, OH |
| 9 | Sat Oct 26 | atBuffalo | L20-43 | 5-4 | .556 | UB Stadium · Buffalo, NY |
| 10 | Sat Nov 2 | vsN Illinois | W48-10 | 6-4 | .600 | Kelly/Shorts Stadium · Mount Pleasant, MI |
| 11 | Sat Nov 16 | atBall State | W45-44 | 7-4 | .636 | Scheumann Stadium · Muncie, IN |
| 12 | Fri Nov 29 | vsToledo | W49-7 | 8-4 | .667 | Kelly/Shorts Stadium · Mount Pleasant, MI |
| 13 | Sat Dec 7 | vsMiami OH | L21-26 | 8-5 | .615 | Kelly/Shorts Stadium · Mount Pleasant, MI |
| BOWLS | Sat Dec 21 | atSDSU | L11-48 | 8-6 | .571 | SDCCU Stadium · San Diego, CA |
