| 1 | Thu Sep 1 | at #12Oklahoma St | L44-58 | 0-1 | .000 | Boone Pickens Stadium · Stillwater, OK |
| 2 | Sat Sep 10 | vsSouth Alabama | L24-38 | 0-2 | .000 | Kelly/Shorts Stadium · Mount Pleasant, MI |
| 3 | Sat Sep 17 | vsBucknell | W41-0 | 1-2 | .333 | Kelly/Shorts Stadium · Mount Pleasant, MI |
| 4 | Sat Sep 24 | at#14Penn State | L14-33 | 1-3 | .250 | Beaver Stadium · University Park, PA |
| 5 | Sat Oct 1 | atToledo | L17-38 | 1-4 | .200 | Glass Bowl · Toledo, OH |
| 6 | Sat Oct 8 | vsBall State | L16-17 | 1-5 | .167 | Kelly/Shorts Stadium · Mount Pleasant, MI |
| 7 | Sat Oct 15 | atAkron | W28-21 | 2-5 | .286 | InfoCision Stadium · Akron, OH |
| 8 | Sat Oct 22 | vsBowling Green | L18-34 | 2-6 | .250 | Kelly/Shorts Stadium · Mount Pleasant, MI |
| 9 | Wed Nov 2 | atN Illinois | W35-22 | 3-6 | .333 | Huskie Stadium · Dekalb, IL |
| 10 | Wed Nov 9 | vsBuffalo | W31-27 | 4-6 | .400 | Kelly/Shorts Stadium · Mount Pleasant, MI |
| 11 | Wed Nov 16 | vsW Michigan | L10-12 | 4-7 | .364 | Kelly/Shorts Stadium · Mount Pleasant, MI |
| 12 | Fri Nov 25 | atE Michigan | L19-38 | 4-8 | .333 | Rynearson Stadium · Ypsilanti, MI |
