| 1 | Thu Sep 2 | at Appalachian St | L19-33 | 0-1 | .000 | Kidd Brewer Stadium · Boone, NC |
| 2 | Sat Sep 11 | vsSouth Carolina | L17-20 | 0-2 | .000 | Dowdy-Ficklen Stadium · Greenville, NC |
| 3 | Sat Sep 18 | atMarshall | W42-38 | 1-2 | .333 | Joan C. Edwards Stadium · Huntington, WV |
| 4 | Sat Sep 25 | vsCharleston So | W31-28 | 2-2 | .500 | Dowdy-Ficklen Stadium · Greenville, NC |
| 5 | Sat Oct 2 | vsTulane | W52-29 | 3-2 | .600 | Dowdy-Ficklen Stadium · Greenville, NC |
| 6 | Sat Oct 9 | atUCF | L16-20 | 3-3 | .500 | FBC Mortgage Stadium · Orlando, FL |
| 7 | Sat Oct 23 | atHouston | L24-31 (OT) | 3-4 | .429 | Robertson Stadium · Houston, TX |
| 8 | Thu Oct 28 | vsSouth Florida | W29-14 | 4-4 | .500 | Dowdy-Ficklen Stadium · Greenville, NC |
| 9 | Sat Nov 6 | vsTemple | W45-3 | 5-4 | .556 | Dowdy-Ficklen Stadium · Greenville, NC |
| 10 | Sat Nov 13 | atMemphis | W30-29 (OT) | 6-4 | .600 | Simmons Bank Liberty Stadium · Memphis, TN |
| 11 | Sat Nov 20 | atNavy | W38-35 | 7-4 | .636 | Navy-Marine Corps Memorial Stadium · Annapolis, MD |
| 12 | Fri Nov 26 | vs#4Cincinnati | L13-35 | 7-5 | .583 | Dowdy-Ficklen Stadium · Greenville, NC |
