| 1 | Sun Sep 1 | vs Houston | W49-31 | 1-0 | 1.000 | Memorial Stadium · Norman, OK |
| 2 | Sat Sep 7 | vsSouth Dakota | W70-14 | 2-0 | 1.000 | Memorial Stadium · Norman, OK |
| 3 | Sat Sep 14 | atUCLA | W48-14 | 3-0 | 1.000 | Rose Bowl · Pasadena, CA |
| 4 | Sat Sep 28 | vsTexas Tech | W55-16 | 4-0 | 1.000 | Memorial Stadium · Norman, OK |
| 5 | Sat Oct 5 | atKansas | W45-20 | 5-0 | 1.000 | David Booth Kansas Memorial Stadium · Lawrence, KS |
| 6 | Sat Oct 12 | at#11Texas | W34-27 | 6-0 | 1.000 | DKR-Texas Memorial Stadium · Austin, TX |
| 7 | Sat Oct 19 | vsWest Virginia | W52-14 | 7-0 | 1.000 | Memorial Stadium · Norman, OK |
| 8 | Sat Oct 26 | atKansas St | L41-48 | 7-1 | .875 | Bill Snyder Family Stadium · Manhattan, KS |
| 9 | Sat Nov 9 | vsIowa State | W42-41 | 8-1 | .889 | Memorial Stadium · Norman, OK |
| 10 | Sat Nov 16 | at#13Baylor | W34-31 | 9-1 | .900 | Floyd Casey Stadium · Waco, TX |
| 11 | Sat Nov 23 | vsTCU | W28-24 | 10-1 | .909 | Memorial Stadium · Norman, OK |
| 12 | Sat Nov 30 | at#21Oklahoma St | W34-16 | 11-1 | .917 | Boone Pickens Stadium · Stillwater, OK |
| 13 | Sat Dec 7 | vs#7Baylor | W30-23 (OT) | 12-1 | .923 | Memorial Stadium · Norman, OK |
| BOWLS | Sat Dec 28 | at#1LSU | L28-63 | 12-2 | .857 | Tiger Stadium · Baton Rouge, LA |
