| 1 | Sat Aug 30 | vs Illinois St | W35-3 | 1-0 · #18 | 1.000 | Memorial Stadium · Norman, OK |
| 2 | Sat Sep 6 | vs15Michigan | W24-13 | 2-0 · #18 | 1.000 | Memorial Stadium · Norman, OK |
| 3 | Sat Sep 13 | atTemple | W42-3 | 3-0 · #13 | 1.000 | Lincoln Financial Field · Philadelphia, PA |
| 4 | Sat Sep 20 | vs22Auburn | W24-17 | 4-0 · #11 | 1.000 | Memorial Stadium · Norman, OK |
| 5 | Sat Oct 4 | vsKent State | W44-0 | 5-0 · #5 | 1.000 | Memorial Stadium · Norman, OK |
| 6 | Sat Oct 11 | atTexas | L6-23 | 5-1 · #6 | .833 | DKR-Texas Memorial Stadium · Austin, TX |
| 7 | Sat Oct 18 | atSouth Carolina | W26-7 | 6-1 · #14 | .857 | Williams-Brice Stadium · Columbia, SC |
| 8 | Sat Oct 25 | vs8Ole Miss | L26-34 | 6-2 · #13 | .750 | Memorial Stadium · Norman, OK |
| 9 | Sat Nov 1 | at14Tennessee | W33-27 | 7-2 · #18 | .778 | Neyland Stadium · Knoxville, TN |
| 10 | Sat Nov 15 | at4Alabama | W23-21 | 8-2 · #11 | .800 | Bryant-Denny Stadium · Tuscaloosa, AL |
| 11 | Sat Nov 22 | vs22Missouri | W17-6 | 9-2 · #8 | .818 | Memorial Stadium · Norman, OK |
| 12 | Sat Nov 29 | vsLSU | W17-13 | 10-2 · #8 | .833 | Memorial Stadium · Norman, OK |
| CFP | Fri Dec 19 | vs9Alabama | L24-34 | 10-3 · #8 | .769 | Memorial Stadium · Norman, OK |
