| 1 | Fri Sep 2 | at Duke | L0-30 | 0-1 | .000 | Wallace Wade Stadium · Durham, NC |
| 2 | Sat Sep 10 | vsLafayette | W30-14 | 1-1 | .500 | Lincoln Financial Field · Philadelphia, PA |
| 3 | Sat Sep 17 | vsRutgers | L14-16 | 1-2 | .333 | Lincoln Financial Field · Philadelphia, PA |
| 4 | Sat Sep 24 | vsUMass | W28-0 | 2-2 | .500 | Lincoln Financial Field · Philadelphia, PA |
| 5 | Sat Oct 1 | atMemphis | L3-24 | 2-3 | .400 | Simmons Bank Liberty Stadium · Memphis, TN |
| 6 | Thu Oct 13 | atUCF | L13-70 | 2-4 | .333 | FBC Mortgage Stadium · Orlando, FL |
| 7 | Fri Oct 21 | vsTulsa | L16-27 | 2-5 | .286 | Lincoln Financial Field · Philadelphia, PA |
| 8 | Sat Oct 29 | atNavy | L20-27 (OT) | 2-6 | .250 | Navy-Marine Corps Memorial Stadium · Annapolis, MD |
| 9 | Sat Nov 5 | vsSouth Florida | W54-28 | 3-6 | .333 | Lincoln Financial Field · Philadelphia, PA |
| 10 | Sat Nov 12 | atHouston | L36-43 | 3-7 | .300 | Robertson Stadium · Houston, TX |
| 11 | Sat Nov 19 | vs#25Cincinnati | L3-23 | 3-8 | .273 | Lincoln Financial Field · Philadelphia, PA |
| 12 | Sat Nov 26 | vsE Carolina | L46-49 | 3-9 | .250 | Lincoln Financial Field · Philadelphia, PA |
