| 1 | Tue Nov 4 | at UNLV | W86-81 | 1-0 | 1.000 | - | | Thomas & Mack Center · Las Vegas, NV |
| 2 | Sun Nov 9 | vsTBD | W97-42 | 2-0 | 1.000 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 3 | Wed Nov 12 | atBradley | W78-67 | 3-0 | 1.000 | - | ESPN+ | Carver Arena · Peoria, IL |
| 4 | Tue Nov 18 | atFlorida St | L73-87 | 3-1 | .750 | - | ACC Extra | Donald L. Tucker Center · Tallahassee, FL |
| 5 | Sat Nov 22 | atPrairie View | W69-68 | 4-1 | .800 | - | | William Nicks Building · Prairie View, TX |
| 6 | Sun Nov 23 | atSouthern Miss | L60-70 | 4-2 | .667 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 7 | Tue Nov 25 | vsTBD | W75-50 | 5-2 | .714 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 8 | Tue Dec 2 | vsCharleston So | W73-56 | 6-2 | .750 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 9 | Sun Dec 7 | vsAlabama St | W74-64 | 7-2 | .778 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 10 | Wed Dec 10 | atS Illinois | L54-83 | 7-3 | .700 | - | ESPN+ | Banterra Center · Carbondale, IL |
| 11 | Sun Dec 14 | vsTBD | W96-52 | 8-3 | .727 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 12 | Thu Dec 18 | atTennessee St | L71-78 | 8-4 | .667 | - | ESPN+ | Gentry Center · Nashville, TN |
| 13 | Sat Dec 20 | atTennessee Tech | W86-62 | 9-4 | .692 | - | ESPN+ | Hooper Eblen Center · Cookeville, TN |
| 14 | Thu Jan 1 | vsW Illinois | W67-60 | 10-4 | .714 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 15 | Sat Jan 3 | vsE Illinois | W65-61 | 11-4 | .733 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 16 | Thu Jan 8 | atMorehead St | W76-68 | 12-4 | .750 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 17 | Sat Jan 10 | atSo Indiana | W73-56 | 13-4 | .765 | - | ESPN+ | Screaming Eagles Arena · Evansville, IN |
| 18 | Thu Jan 15 | vsSIUE | W65-59 | 14-4 | .778 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 19 | Sat Jan 17 | vsLindenwood | W69-55 | 15-4 | .789 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 20 | Tue Jan 20 | atSE Missouri St | L50-66 | 15-5 | .750 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 21 | Thu Jan 29 | atE Illinois | W76-68 | 16-5 | .762 | - | ESPN+ | Lantz Arena · Charleston, IL |
| 22 | Sat Jan 31 | atW Illinois | W84-44 | 17-5 | .773 | - | ESPN+ | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 23 | Tue Feb 3 | vsLittle Rock | W55-52 | 18-5 | .783 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 24 | Thu Feb 5 | vsSo Indiana | W76-54 | 19-5 | .792 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 25 | Sat Feb 7 | vsMorehead St | L55-61 | 19-6 | .760 | - | ESPNU | Kathleen and Tom Elam Center · Martin, TN |
| 26 | Thu Feb 12 | atLindenwood | L74-75 | 19-7 | .731 | - | ESPN+ | placeholder · sf, ca |
| 27 | Sat Feb 14 | atSIUE | W81-76 | 20-7 | .741 | - | ESPN+ | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 28 | Tue Feb 17 | vsSE Missouri St | L53-56 (OT) | 20-8 | .714 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 29 | Thu Feb 19 | atLittle Rock | L65-67 | 20-9 | .690 | - | ESPN+ | Jack Stephens Center · Little Rock, AR |
| 30 | Thu Feb 26 | vsTennessee Tech | W64-49 | 21-9 | .700 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 31 | Sat Feb 28 | vsTennessee St | L42-67 | 21-10 | .677 | - | ESPNU | Kathleen and Tom Elam Center · Martin, TN |
