| 1 | Mon Nov 4 | vs TBD | W95-42 | 1-0 | 1.000 | - | ESPN+ | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 2 | Wed Nov 6 | at #17Indiana | L61-80 | 1-1 | .500 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 3 | Fri Nov 8 | at Illinois | L58-90 | 1-2 | .333 | - | Peacock | State Farm Center · Champaign, IL |
| 4 | Tue Nov 12 | at Indiana St | W77-72 | 2-2 | .500 | - | ESPN+ | Hulman Center · Terre Haute, IN |
| 5 | Fri Nov 15 | at W Michigan | W79-60 | 3-2 | .600 | - | ESPN+ | University Arena (MI) · Kalamazoo, MI |
| 6 | Sat Nov 16 | at Canisius | W76-58 | 4-2 | .667 | - | | Koessler Athletic Center · Buffalo, NY |
| 7 | Tue Nov 19 | at Green Bay | L57-82 | 4-3 | .571 | - | ESPN+ | Resch Center · Ashwaubenon, WI |
| 8 | Sat Nov 23 | vsTBD | W83-49 | 5-3 | .625 | - | ESPN+ | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 9 | Fri Nov 29 | vs North Florida | L73-78 | 5-4 | .556 | - | ESPN+ | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 10 | Sun Dec 8 | vs Ball State | W82-69 | 6-4 | .600 | - | ESPN+ | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 11 | Sun Dec 15 | vsTBD | W100-52 | 7-4 | .636 | - | ESPN+ | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 12 | Thu Dec 19 | at Little Rock | L56-60 | 7-5 | .583 | - | ESPN+ | Jack Stephens Center · Little Rock, AR |
| 13 | Sat Dec 21 | at SE Missouri St | L64-80 | 7-6 | .538 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 14 | Thu Jan 2 | vs W Illinois | W77-66 | 8-6 | .571 | - | ESPNU | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 15 | Sat Jan 4 | vs Lindenwood | W58-47 | 9-6 | .600 | - | ESPN+ | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 16 | Tue Jan 7 | at E Illinois | W60-57 | 10-6 | .625 | - | ESPN+ | Lantz Arena · Charleston, IL |
| 17 | Sat Jan 11 | vs Tennessee Tech | W67-59 | 11-6 | .647 | - | ESPN+ | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 18 | Thu Jan 16 | at Tennessee St | W87-80 (2OT) | 12-6 | .667 | - | ESPN+ | Gentry Center · Nashville, TN |
| 19 | Sat Jan 18 | at UT Martin | L82-85 | 12-7 | .632 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 20 | Thu Jan 23 | vs So Indiana | W82-76 | 13-7 | .650 | - | ESPN+ | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 21 | Sat Jan 25 | vs Morehead St | W65-54 | 14-7 | .667 | - | ESPN+ | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 22 | Thu Jan 30 | atLindenwood | L63-65 | 14-8 | .636 | - | ESPN+ | placeholder · sf, ca |
| 23 | Sat Feb 1 | atW Illinois | W69-65 | 15-8 | .652 | - | ESPN+ | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 24 | Tue Feb 4 | vsE Illinois | W66-41 | 16-8 | .667 | - | ESPN+ | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 25 | Thu Feb 6 | atTennessee Tech | W75-58 | 17-8 | .680 | - | ESPN+ | Hooper Eblen Center · Cookeville, TN |
| 26 | Thu Feb 13 | vsUT Martin | L71-76 | 17-9 | .654 | - | ESPN+ | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 27 | Sat Feb 15 | vsTennessee St | W84-72 | 18-9 | .667 | - | ESPN+ | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 28 | Thu Feb 20 | atMorehead St | W80-62 | 19-9 | .679 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
