| 1 | Wed Nov 5 | vs TBD | W97-30 | 1-0 | 1.000 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 2 | Fri Nov 7 | vsSIUE | L60-77 | 1-1 | .500 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 3 | Wed Nov 12 | atTexas St | L69-80 | 1-2 | .333 | - | ESPN+ | Strahan Arena · San Marcos, TX |
| 4 | Sat Nov 15 | atDenver | W84-79 | 2-2 | .500 | - | | Hamilton Gymnasium · Denver, CO |
| 5 | Tue Nov 18 | vsTBD | W103-70 | 3-2 | .600 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 6 | Mon Nov 24 | atAbilene Chrstn | L50-61 | 3-3 | .500 | - | | Moody Coliseum (Abilene) · Abilene, TX |
| 7 | Tue Nov 25 | atGeorgia So | W77-64 | 4-3 | .571 | - | | W.S. Hanner Fieldhouse · Statesboro, GA |
| 8 | Sun Nov 30 | vsSouth Alabama | L58-82 | 4-4 | .500 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 9 | Sun Dec 7 | at12Alabama | L55-97 | 4-5 | .444 | - | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 10 | Sat Dec 13 | atColorado | L64-88 | 4-6 | .400 | - | ESPN+ | CU Events Center · Boulder, CO |
| 11 | Wed Dec 17 | atUSC | L70-97 | 4-7 | .364 | - | BTN | Galen Center · Los Angeles, CA |
| 12 | Mon Dec 22 | vsSeattle U | L68-71 | 4-8 | .333 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 13 | Wed Dec 31 | atFAU | L70-110 | 4-9 | .308 | - | ESPN+ | FAU Arena · Boca Raton, FL |
| 14 | Sat Jan 3 | atTemple | L57-76 | 4-10 | .286 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 15 | Wed Jan 7 | vsCharlotte | L58-74 | 4-11 | .267 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 16 | Sat Jan 10 | vsTulane | L52-85 | 4-12 | .250 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 17 | Wed Jan 14 | vsRice | L73-89 | 4-13 | .235 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 18 | Sun Jan 18 | atMemphis | L69-95 | 4-14 | .222 | - | ESPNU | FedExForum · Memphis, TN |
| 19 | Wed Jan 21 | atNorth Texas | L62-81 | 4-15 | .211 | - | ESPN+ | The Super Pit · Denton, TX |
| 20 | Sat Jan 24 | vsTemple | L64-70 | 4-16 | .200 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 21 | Wed Jan 28 | vsUAB | L73-83 | 4-17 | .190 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 22 | Wed Feb 4 | atSouth Florida | L88-109 | 4-18 | .182 | - | ESPN+ | Yuengling Center · Tampa, FL |
| 23 | Sat Feb 7 | vsNorth Texas | L58-81 | 4-19 | .174 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 24 | Wed Feb 11 | atE Carolina | L72-88 | 4-20 | .167 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 25 | Sun Feb 15 | atCharlotte | W88-79 | 5-20 | .200 | - | ESPNU | Dale F. Halton Arena · Charlotte, NC |
| 26 | Wed Feb 18 | vsFAU | L52-60 | 5-21 | .192 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 27 | Sun Feb 22 | atTulsa | L74-100 | 5-22 | .185 | - | ESPNEWS | Donald W. Reynolds Center · Tulsa, OK |
| 28 | Wed Feb 25 | vsE Carolina | L81-82 | 5-23 | .179 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 29 | Sun Mar 1 | vsWichita St | L67-84 | 5-24 | .172 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
