| 1 | Tue Nov 4 | vs UNC Asheville | W75-58 | 1-0 | 1.000 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 2 | Sat Nov 8 | vsPrairie View | W105-62 | 2-0 | 1.000 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 3 | Thu Nov 13 | vsLoyola Chicago | W95-74 | 3-0 | 1.000 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 4 | Tue Nov 18 | atBoise St | L59-62 | 3-1 | .750 | - | | ExtraMile Arena · Boise, ID |
| 5 | Sat Nov 22 | vsMilwaukee | W75-58 | 4-1 | .800 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 6 | Wed Nov 26 | vsSaint Mary's | L65-70 | 4-2 | .667 | - | ESPN2 | Charles Koch Arena · Wichita, KS |
| 7 | Thu Nov 27 | atColorado St | L70-76 | 4-3 | .571 | - | ESPNU | Moby Arena · Fort Collins, CO |
| 8 | Fri Nov 28 | atWestern KY | L70-75 | 4-4 | .500 | - | ESPNU | E. A. Diddle Arena · Bowling Green, KY |
| 9 | Tue Dec 2 | vsTBD | W95-69 | 5-4 | .556 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 10 | Sat Dec 6 | atNorthern Iowa | W74-69 (OT) | 6-4 | .600 | - | ESPN+ | McLeod Center · Cedar Falls, IA |
| 11 | Sat Dec 13 | vsDePaul | L58-61 | 6-5 | .545 | - | ESPNU | Charles Koch Arena · Wichita, KS |
| 12 | Wed Dec 17 | vsWofford | W84-73 | 7-5 | .583 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 13 | Sun Dec 21 | vsE Kentucky | W88-57 | 8-5 | .615 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 14 | Wed Dec 31 | atUAB | W75-70 | 9-5 | .643 | - | ESPNU | Bartow Arena · Birmingham, AL |
| 15 | Sat Jan 3 | atCharlotte | L100-104 (2OT) | 9-6 | .600 | - | ESPNU | Dale F. Halton Arena · Charlotte, NC |
| 16 | Wed Jan 7 | vsRice | L64-66 | 9-7 | .563 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 17 | Sun Jan 11 | vsNorth Texas | W78-67 | 10-7 | .588 | - | ESPNU | Charles Koch Arena · Wichita, KS |
| 18 | Thu Jan 15 | atFAU | L67-85 | 10-8 | .556 | - | ESPN2 | FAU Arena · Boca Raton, FL |
| 19 | Sun Jan 18 | atSouth Florida | W86-85 (OT) | 11-8 | .579 | - | ESPNU | Yuengling Center · Tampa, FL |
| 20 | Wed Jan 21 | vsE Carolina | W77-60 | 12-8 | .600 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 21 | Sat Jan 24 | vsMemphis | W74-59 | 13-8 | .619 | - | ESPN2 | Charles Koch Arena · Wichita, KS |
| 22 | Sun Feb 1 | atTulsa | L83-93 | 13-9 | .591 | - | ESPNU | Donald W. Reynolds Center · Tulsa, OK |
| 23 | Wed Feb 4 | vsCharlotte | W74-64 | 14-9 | .609 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 24 | Sun Feb 8 | atTulane | W75-61 | 15-9 | .625 | - | ESPN+ | Devlin Fieldhouse · New Orleans, LA |
| 25 | Wed Feb 11 | vsSouth Florida | L58-66 | 15-10 | .600 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 26 | Sat Feb 14 | vsTulsa | W81-77 | 16-10 | .615 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 27 | Wed Feb 18 | atE Carolina | W92-89 (2OT) | 17-10 | .630 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 28 | Sat Feb 21 | vsTemple | W69-57 | 18-10 | .643 | - | ESPN2 | Charles Koch Arena · Wichita, KS |
| 29 | Thu Feb 26 | atMemphis | W88-82 | 19-10 | .655 | - | ESPN2 | FedExForum · Memphis, TN |
| 30 | Sun Mar 1 | atUTSA | W84-67 | 20-10 | .667 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 31 | Sat Mar 7 | vsFAU | W88-70 | 21-10 | .677 | - | ESPNU | Charles Koch Arena · Wichita, KS |
| 32 | Sat Mar 14 | vsTulsa | W81-68 | 22-10 | .688 | - | ESPN2 | Charles Koch Arena · Wichita, KS |
| 33 | Sun Mar 15 | atSouth Florida | L55-70 | 22-11 | .667 | - | ESPN | Yuengling Center · Tampa, FL |
| 34 | Tue Mar 17 | vsWyoming | W74-70 | 23-11 | .676 | - | ESPNU | Charles Koch Arena · Wichita, KS |
| 35 | Sun Mar 22 | atOklahoma St | W96-70 | 24-11 | .686 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 36 | Tue Mar 24 | atTulsa | L79-83 | 24-12 | .667 | - | ESPN2 | Donald W. Reynolds Center · Tulsa, OK |
