| 1 | Mon Nov 4 | vs Wright St | W103-62 | 1-0 | 1.000 | #23 | ESPNU | Rupp Arena · Lexington, KY |
| 2 | Sat Nov 9 | vs Bucknell | W100-72 | 2-0 | 1.000 | #23 | ESPN+ | Rupp Arena · Lexington, KY |
| 3 | Tue Nov 12 | vs #6Duke | W77-72 | 3-0 | 1.000 | #19 | ESPN | Rupp Arena · Lexington, KY |
| 4 | Tue Nov 19 | vs Lipscomb | W97-68 | 4-0 | 1.000 | #9 | ESPN+ | Rupp Arena · Lexington, KY |
| 5 | Fri Nov 22 | vs Jackson St | W108-59 | 5-0 | 1.000 | #9 | ESPN+ | Rupp Arena · Lexington, KY |
| 6 | Tue Nov 26 | vs Western KY | W87-68 | 6-0 | 1.000 | #8 | ESPNU | Rupp Arena · Lexington, KY |
| 7 | Fri Nov 29 | vs Georgia St | W105-76 | 7-0 | 1.000 | #8 | SEC Network | Rupp Arena · Lexington, KY |
| 8 | Tue Dec 3 | at Clemson | L66-70 | 7-1 | .875 | #4 | ESPN | Littlejohn Coliseum · Clemson, SC |
| 9 | Sat Dec 7 | at #7Gonzaga | W90-89 (OT) | 8-1 | .889 | #4 | ESPN2 | McCarthey Athletic Center · Spokane, WA |
| 10 | Wed Dec 11 | vs Colgate | W78-67 | 9-1 | .900 | #5 | ESPN2 | Rupp Arena · Lexington, KY |
| 11 | Sat Dec 14 | vs Louisville | W93-85 | 10-1 | .909 | #5 | ESPN | Rupp Arena · Lexington, KY |
| 12 | Sat Dec 21 | at Ohio State | L65-85 | 10-2 | .833 | #4 | CBS | Value City Arena · Columbus, OH |
| 13 | Tue Dec 31 | vs Brown | W88-54 | 11-2 | .846 | #10 | ESPNU | Rupp Arena · Lexington, KY |
| 14 | Sat Jan 4 | vs #6Florida | W106-100 | 12-2 | .857 | #10 | ESPN | Rupp Arena · Lexington, KY |
| 15 | Tue Jan 7 | at Georgia | L69-82 | 12-3 | .800 | #6 | SEC Network | Stegeman Coliseum · Athens, GA |
| 16 | Sat Jan 11 | at #14Mississippi St | W95-90 | 13-3 | .813 | #6 | SEC Network | Humphrey Coliseum · Starkville, MS |
| 17 | Tue Jan 14 | vs #11Texas A&M | W81-69 | 14-3 | .824 | #8 | ESPN2 | Rupp Arena · Lexington, KY |
| 18 | Sat Jan 18 | vs #4Alabama | L97-102 | 14-4 | .778 | #8 | ESPN | Rupp Arena · Lexington, KY |
| 19 | Sat Jan 25 | at Vanderbilt | L69-74 | 14-5 | .737 | #9 | ESPN | Memorial Gymnasium (TN) · Nashville, TN |
| 20 | Tue Jan 28 | at #8Tennessee | W78-73 | 15-5 | .750 | #12 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 21 | Sat Feb 1 | vs Arkansas | L79-89 | 15-6 | .714 | #12 | ESPN | Rupp Arena · Lexington, KY |
| 22 | Tue Feb 4 | at #25Ole Miss | L84-98 | 15-7 | .682 | #14 | ESPN | SJB Pavilion · Oxford, MS |
| 23 | Sat Feb 8 | vs South Carolina | W80-57 | 16-7 | .696 | #14 | ESPN2 | Rupp Arena · Lexington, KY |
| 24 | Tue Feb 11 | vs#5Tennessee | W75-64 | 17-7 | .708 | #15 | ESPN | Rupp Arena · Lexington, KY |
| 25 | Sat Feb 15 | at Texas | L78-82 | 17-8 | .680 | #15 | ESPN | Moody Center · Austin, TX |
| 26 | Wed Feb 19 | vsVanderbilt | W82-61 | 18-8 | .692 | #17 | SEC Network | Rupp Arena · Lexington, KY |
| 27 | Sat Feb 22 | at#4Alabama | L83-96 | 18-9 | .667 | #17 | ESPN | Coleman Coliseum · Tuscaloosa, AL |
| 28 | Wed Feb 26 | at Oklahoma | W83-82 | 19-9 | .679 | #17 | SEC Network | Lloyd Noble Center · Norman, OK |
| 29 | Sat Mar 1 | vs #1Auburn | L78-94 | 19-10 | .655 | #17 | ABC | Rupp Arena · Lexington, KY |
| 30 | Tue Mar 4 | vs LSU | W95-64 | 20-10 | .667 | #19 | ESPN2 | Rupp Arena · Lexington, KY |
| 31 | Sat Mar 8 | at #15Missouri | W91-83 | 21-10 | .677 | #19 | ESPN | Mizzou Arena · Columbia, MO |
| 32 | Thu Mar 13 | vsOklahoma | W85-84 | 22-10 | .688 | #15 | SEC Network | Rupp Arena · Lexington, KY |
| 33 | Fri Mar 14 | at#5Alabama | L70-99 | 22-11 | .667 | #15 | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 34 | Fri Mar 21 | vs #14Troy | W76-57 | 23-11 | .676 | #3 | CBS | Rupp Arena · Lexington, KY |
| 35 | Sun Mar 23 | vs #6Illinois | W84-75 | 24-11 | .686 | #3 | CBS | Rupp Arena · Lexington, KY |
| 36 | Fri Mar 28 | at#2Tennessee | L65-78 | 24-12 | .667 | #3 | TBS | Thompson-Boling Arena · Knoxville, TN |
