| 9 | Fri Dec 5 | vs #11Gonzaga | 7:00 PM | 7-1 | .875 | #18 | ESPN2 | Rupp Arena · Lexington, KY |
| 10 | Tue Dec 9 | vsNC Central | 7:00 PM | 3-7 | .300 | #18 | SEC Network | Rupp Arena · Lexington, KY |
| 11 | Sat Dec 13 | vs#22Indiana | 7:30 PM | 7-1 | .875 | #18 | ESPN | Rupp Arena · Lexington, KY |
| 12 | Sat Dec 20 | vs#23St John's | 12:30 PM | 4-3 | .571 | #18 | CBS | State Farm Arena · Atlanta, GA |
| 13 | Tue Dec 23 | vsBellarmine | 1:00 PM | 4-4 | .500 | #18 | SECN+ | Rupp Arena · Lexington, KY |
| 14 | Sat Jan 3 | at#12Alabama | 1:00 PM | 6-2 | .750 | #18 | ESPN | Coleman Coliseum · Tuscaloosa, AL |
| 15 | Wed Jan 7 | vsMissouri | 7:00 PM | 8-1 | .889 | #18 | ESPN2 | Rupp Arena · Lexington, KY |
| 16 | Sat Jan 10 | vsMississippi St | 8:30 PM | 4-4 | .500 | #18 | SEC Network | Rupp Arena · Lexington, KY |
| 17 | Wed Jan 14 | atLSU | 7:00 PM | 8-0 | 1.000 | #18 | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 18 | Sat Jan 17 | at#13Tennessee | 12:00 PM | 7-2 | .778 | #18 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 19 | Wed Jan 21 | vsTexas | 7:00 PM | 6-3 | .667 | #18 | SEC Network | Rupp Arena · Lexington, KY |
| 20 | Sat Jan 24 | vsOle Miss | 12:00 PM | 5-3 | .625 | #18 | ESPN | Rupp Arena · Lexington, KY |
| 21 | Tue Jan 27 | at#17Vanderbilt | 9:00 PM | 9-0 | 1.000 | #18 | ESPN | Memorial Gymnasium (TN) · Nashville, TN |
| 22 | Sat Jan 31 | at#25Arkansas | 6:30 PM | 6-2 | .750 | #18 | ESPN | Bud Walton Arena · Fayetteville, AR |
| 23 | Wed Feb 4 | vsOklahoma | 7:00 PM | 6-2 | .750 | #18 | ESPN2 | Rupp Arena · Lexington, KY |
| 24 | Sat Feb 7 | vs#13Tennessee | 8:30 PM | 7-2 | .778 | #18 | ESPN | Rupp Arena · Lexington, KY |
| 25 | Sat Feb 14 | at#15Florida | 3:00 PM | 5-3 | .625 | #18 | ABC | O'Connell Center · Gainesville, FL |
| 26 | Tue Feb 17 | vsGeorgia | 9:00 PM | 8-1 | .889 | #18 | | Rupp Arena · Lexington, KY |
| 27 | Sat Feb 21 | at#20Auburn | 8:30 PM | 7-2 | .778 | #18 | ESPN | Neville Arena · Auburn, AL |
| 28 | Tue Feb 24 | atSouth Carolina | 7:00 PM | 5-3 | .625 | #18 | SEC Network | Colonial Life Arena · Columbia, SC |
| 29 | Sat Feb 28 | vs#17Vanderbilt | 2:00 PM | 9-0 | 1.000 | #18 | | Rupp Arena · Lexington, KY |
| 30 | Tue Mar 3 | atTexas A&M | 7:00 PM | 7-2 | .778 | #18 | | Reed Arena · College Station, TX |
| 31 | Sat Mar 7 | vs#15Florida | 4:00 PM | 5-3 | .625 | #18 | ESPN | Rupp Arena · Lexington, KY |
