| 1 | Wed Nov 5 | vs Alabama A&M | W98-51 | 1-0 | 1.000 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 2 | Sun Nov 9 | atMarquette | W100-77 | 2-0 | 1.000 | - | ESPN | Fiserv Forum · Milwaukee, WI |
| 3 | Wed Nov 12 | vsMilwaukee | W101-70 | 3-0 | 1.000 | - | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 4 | Sun Nov 16 | vsIncarnate Word | W69-61 | 4-0 | 1.000 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 5 | Thu Nov 20 | vsLindenwood | W73-53 | 5-0 | 1.000 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 6 | Tue Nov 25 | vsKansas St | W86-69 | 6-0 | 1.000 | #25 | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 7 | Sat Nov 29 | vsBethune | W100-56 | 7-0 | 1.000 | #25 | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 8 | Wed Dec 3 | atMinnesota | L64-73 | 7-1 | .875 | #22 | BTN | Williams Arena · Minneapolis, MN |
| 9 | Sat Dec 6 | at6Louisville | L78-87 | 7-2 | .778 | #22 | CBS | KFC Yum! Center · Louisville, KY |
| 10 | Tue Dec 9 | vsPenn State | W113-72 | 8-2 | .800 | - | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 11 | Sat Dec 13 | atKentucky | L60-72 | 8-3 | .727 | - | ESPN | Rupp Arena · Lexington, KY |
| 12 | Sat Dec 20 | vsChicago St | W78-58 | 9-3 | .750 | - | B1G+ | Simon Skjodt Assembly Hall · Bloomington, IN |
| 13 | Mon Dec 22 | vsSiena | W81-60 | 10-3 | .769 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 14 | Sun Jan 4 | vsWashington | W90-80 | 11-3 | .786 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 15 | Wed Jan 7 | atMaryland | W84-66 | 12-3 | .800 | - | BTN | XFINITY Center · College Park, MD |
| 16 | Sat Jan 10 | vs10Nebraska | L77-83 | 12-4 | .750 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 17 | Tue Jan 13 | at12Michigan St | L60-81 | 12-5 | .706 | - | Peacock | Breslin Center · East Lansing, MI |
| 18 | Sat Jan 17 | vsIowa | L57-74 | 12-6 | .667 | - | FOX | Simon Skjodt Assembly Hall · Bloomington, IN |
| 19 | Tue Jan 20 | at3Michigan | L72-86 | 12-7 | .632 | - | Peacock | Crisler Center · Ann Arbor, MI |
| 20 | Fri Jan 23 | atRutgers | W82-59 | 13-7 | .650 | - | FS1 | Jersey Mike’s Arena · Piscataway, NJ |
| 21 | Tue Jan 27 | vs12Purdue | W72-67 | 14-7 | .667 | - | Peacock | Simon Skjodt Assembly Hall · Bloomington, IN |
| 22 | Sat Jan 31 | atUCLA | W98-97 (2OT) | 15-7 | .682 | - | Peacock | Pauley Pavilion · Los Angeles, CA |
| 23 | Tue Feb 3 | atUSC | L75-81 | 15-8 | .652 | - | Peacock | Galen Center · Los Angeles, CA |
| 24 | Sat Feb 7 | vsWisconsin | W78-77 (OT) | 16-8 | .667 | - | FOX | Simon Skjodt Assembly Hall · Bloomington, IN |
| 25 | Mon Feb 9 | vsOregon | W92-74 | 17-8 | .680 | - | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 26 | Sun Feb 15 | at8Illinois | L51-71 | 17-9 | .654 | - | CBS | State Farm Center · Champaign, IL |
| 27 | Fri Feb 20 | at7Purdue | L64-93 | 17-10 | .630 | - | FOX | Mackey Arena · West Lafayette, IN |
| 28 | Tue Feb 24 | vsNorthwestern | L68-72 | 17-11 | .607 | - | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 29 | Sun Mar 1 | vs13Michigan St | L64-77 | 17-12 | .586 | - | CBS | Simon Skjodt Assembly Hall · Bloomington, IN |
