| 1 | Mon Nov 7 | vs Morehead St | W88-53 | 1-0 | 1.000 | #13 | | Simon Skjodt Assembly Hall · Bloomington, IN |
| 2 | Thu Nov 10 | vsBethune | W101-49 | 2-0 | 1.000 | #13 | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 3 | Fri Nov 18 | atXavier | W81-79 | 3-0 | 1.000 | - | FS1 | Cintas Center · Cincinnati, OH |
| 4 | Sun Nov 20 | vsMiami OH | W86-56 | 4-0 | 1.000 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 5 | Wed Nov 23 | vsLittle Rock | W87-68 | 5-0 | 1.000 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 6 | Fri Nov 25 | vsJackson St | W90-51 | 6-0 | 1.000 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 7 | Wed Nov 30 | vsUNC | W77-65 | 7-0 | 1.000 | - | ESPN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 8 | Sat Dec 3 | atRutgers | L48-63 | 7-1 | .875 | #10 | BTN | Jersey Mike’s Arena · Piscataway, NJ |
| 9 | Wed Dec 7 | vsNebraska | W81-65 | 8-1 | .889 | #14 | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 10 | Sat Dec 10 | atArizona | L75-89 | 8-2 | .800 | - | FOX | McKale Center · Tucson, AZ |
| 11 | Sat Dec 17 | at#8Kansas | L62-84 | 8-3 | .727 | #14 | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 12 | Tue Dec 20 | vsElon | W96-72 | 9-3 | .750 | #18 | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 13 | Fri Dec 23 | vsKennesaw St | W69-55 | 10-3 | .769 | #18 | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 14 | Thu Jan 5 | atIowa | L89-91 | 10-4 | .714 | #15 | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 15 | Sun Jan 8 | vsNorthwestern | L83-84 | 10-5 | .667 | #15 | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 16 | Wed Jan 11 | atPenn State | L66-85 | 10-6 | .625 | - | BTN | Bryce Jordan Center · University Park, PA |
| 17 | Sat Jan 14 | vs#18Wisconsin | W63-45 | 11-6 | .647 | - | CBS | Simon Skjodt Assembly Hall · Bloomington, IN |
| 18 | Thu Jan 19 | atIllinois | W80-65 | 12-6 | .667 | - | FS1 | State Farm Center · Champaign, IL |
| 19 | Sun Jan 22 | vsMichigan St | W82-69 | 13-6 | .684 | - | CBS | Simon Skjodt Assembly Hall · Bloomington, IN |
| 20 | Wed Jan 25 | atMinnesota | W61-57 | 14-6 | .700 | - | BTN | Williams Arena · Minneapolis, MN |
| 21 | Sat Jan 28 | vsOhio State | W86-70 | 15-6 | .714 | - | FOX | Simon Skjodt Assembly Hall · Bloomington, IN |
| 22 | Tue Jan 31 | atMaryland | L55-66 | 15-7 | .682 | #21 | ESPN2 | XFINITY Center · College Park, MD |
| 23 | Sat Feb 4 | vs#1Purdue | W79-74 | 16-7 | .696 | #21 | ESPN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 24 | Tue Feb 7 | vs#24Rutgers | W66-60 | 17-7 | .708 | #18 | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 25 | Sat Feb 11 | atMichigan | W62-61 | 18-7 | .720 | #18 | ESPN | Crisler Center · Ann Arbor, MI |
| 26 | Wed Feb 15 | atNorthwestern | L62-64 | 18-8 | .692 | #14 | BTN | Welsh-Ryan Arena · Evanston, IL |
| 27 | Sat Feb 18 | vsIllinois | W71-68 | 19-8 | .704 | #14 | ESPN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 28 | Tue Feb 21 | atMichigan St | L65-80 | 19-9 | .679 | #17 | ESPN | Breslin Center · East Lansing, MI |
| 29 | Sat Feb 25 | at#5Purdue | W79-71 | 20-9 | .690 | #17 | FOX | Mackey Arena · West Lafayette, IN |
| 30 | Tue Feb 28 | vsIowa | L68-90 | 20-10 | .667 | #15 | ESPN2 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 31 | Sun Mar 5 | vsMichigan | W75-73 (OT) | 21-10 | .677 | #15 | CBS | Simon Skjodt Assembly Hall · Bloomington, IN |
| 32 | Fri Mar 10 | vsMaryland | W70-60 | 22-10 | .688 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 33 | Sat Mar 11 | vsPenn State | L73-77 | 22-11 | .667 | - | CBS | Simon Skjodt Assembly Hall · Bloomington, IN |
| 34 | Fri Mar 17 | vs#13Kent State | W71-60 | 23-11 | .676 | #4 | TBS | Simon Skjodt Assembly Hall · Bloomington, IN |
| 35 | Sun Mar 19 | vs#5Miami | L69-85 | 23-12 | .657 | #4 | TNT | Simon Skjodt Assembly Hall · Bloomington, IN |
