| 1 | Mon Nov 4 | at #4Houston | L40-97 | 0-1 | .000 | - | ESPN+ | Fertitta Center · Houston, TX |
| 2 | Sat Nov 9 | at High Point | L71-80 | 0-2 | .000 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
| 3 | Tue Nov 12 | at Xavier | L57-94 | 0-3 | .000 | - | FS1 | Cintas Center · Cincinnati, OH |
| 4 | Sat Nov 16 | at Vanderbilt | L81-94 | 0-4 | .000 | - | ESPN+ | Memorial Gymnasium (TN) · Nashville, TN |
| 5 | Wed Nov 20 | at Western KY | L62-79 | 0-5 | .000 | - | ESPN+ | E. A. Diddle Arena · Bowling Green, KY |
| 6 | Fri Nov 22 | at #9Kentucky | L59-108 | 0-6 | .000 | - | ESPN+ | Rupp Arena · Lexington, KY |
| 7 | Sun Nov 24 | at Lipscomb | L53-77 | 0-7 | .000 | - | ESPN+ | Allen Arena · Nashville, TN |
| 8 | Mon Dec 2 | at Saint Louis | L66-74 | 0-8 | .000 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 9 | Thu Dec 5 | at Arkansas St | L64-66 | 0-9 | .000 | - | ESPN+ | First National Bank Arena · Jonesboro, AR |
| 10 | Sun Dec 8 | at #6Iowa State | L58-100 | 0-10 | .000 | - | ESPN+ | James H. Hilton Coliseum · Ames, IA |
| 11 | Fri Dec 20 | at UTEP | L61-67 | 0-11 | .000 | - | | Don Haskins Center · El Paso, TX |
| 12 | Sat Dec 21 | vs Akron | L50-68 | 0-12 | .000 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 13 | Sat Dec 28 | at CA Baptist | L73-79 | 0-13 | .000 | - | ESPN+ | CBU Events Center · Riverside, CA |
| 14 | Sat Jan 4 | at Alcorn St | W72-69 | 1-13 | .071 | - | | Davey L. Whitney Complex · Lorman, MS |
| 15 | Sat Jan 11 | vs Alabama St | W77-70 | 2-13 | .133 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 16 | Mon Jan 13 | vs Alabama A&M | W103-93 (3OT) | 3-13 | .188 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 17 | Sat Jan 18 | at Prairie View | W79-70 | 4-13 | .235 | - | | William Nicks Building · Prairie View, TX |
| 18 | Mon Jan 20 | at Texas So | L73-81 | 4-14 | .222 | - | | H&PE Arena · Houston, TX |
| 19 | Sat Jan 25 | vs Bethune | W86-81 | 5-14 | .263 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 20 | Mon Jan 27 | vs FAMU | L62-72 | 5-15 | .250 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 21 | Sat Feb 1 | at Grambling | W65-50 | 6-15 | .286 | - | | Fredrick C. Hobdy Assembly Center · Grambling, LA |
| 22 | Mon Feb 3 | at Southern | L89-91 (OT) | 6-16 | .273 | - | | F. G. Clark Activity Center · Baton Rouge, LA |
| 23 | Sat Feb 8 | vs Miss Valley St | W92-44 | 7-16 | .304 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 24 | Mon Feb 10 | vs AR-Pine Bluff | W94-78 | 8-16 | .333 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 25 | Sat Feb 15 | atFAMU | L71-76 | 8-17 | .320 | - | | Al Lawson Center · Tallahassee, FL |
| 26 | Mon Feb 17 | atBethune | W84-71 | 9-17 | .346 | - | | Moore Gymnasium (FL) · Daytona Beach, FL |
