| 1 | Mon Nov 4 | vs Green Bay | W89-76 | 1-0 | 1.000 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 2 | Sun Nov 10 | vs St Thomas (MN) | W80-71 | 2-0 | 1.000 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 3 | Thu Nov 14 | vs S Illinois | W85-78 | 3-0 | 1.000 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 4 | Thu Nov 21 | at FAU | L78-86 | 3-1 | .750 | - | ESPNU | FAU Arena · Boca Raton, FL |
| 5 | Fri Nov 22 | vs Miami | W80-74 | 4-1 | .800 | - | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
| 6 | Sun Nov 24 | at Nevada | L78-90 | 4-2 | .667 | - | ESPN | Lawlor Events Center · Reno, NV |
| 7 | Wed Dec 4 | at Tulsa | W76-55 | 5-2 | .714 | - | ESPN+ | Donald W. Reynolds Center · Tulsa, OK |
| 8 | Sun Dec 8 | at Seton Hall | W85-76 | 6-2 | .750 | - | FS1 | Prudential Center · Newark, NJ |
| 9 | Sat Dec 14 | at #13Oklahoma | L65-80 | 6-3 | .667 | - | ESPNU | Lloyd Noble Center · Norman, OK |
| 10 | Wed Dec 18 | vs Tarleton | W66-61 | 7-3 | .700 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 11 | Sun Dec 22 | vs Oral Roberts | W86-74 | 8-3 | .727 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 12 | Mon Dec 30 | vs #14Houston | L47-60 | 8-4 | .667 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 13 | Sat Jan 4 | at West Virginia | L50-69 | 8-5 | .615 | - | CBS | WVU Coliseum · Morgantown, WV |
| 14 | Tue Jan 7 | vs Kansas St | W79-66 | 9-5 | .643 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 15 | Sat Jan 11 | at Utah | L62-83 | 9-6 | .600 | - | ESPN+ | Jon M. Huntsman Center · Salt Lake City, UT |
| 16 | Tue Jan 14 | at BYU | L69-85 | 9-7 | .563 | - | ESPN+ | Marriott Center · Provo, UT |
| 17 | Sat Jan 18 | vs Colorado | W83-73 | 10-7 | .588 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 18 | Tue Jan 21 | vs Arizona | L78-92 | 10-8 | .556 | - | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
| 19 | Sun Jan 26 | at Texas Tech | L54-64 | 10-9 | .526 | - | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 20 | Wed Jan 29 | atKansas St | L57-85 | 10-10 | .500 | - | CBS | Bramlage Coliseum · Manhattan, KS |
| 21 | Sat Feb 1 | vsUtah | W81-72 | 11-10 | .524 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 22 | Tue Feb 4 | at#5Houston | L63-72 | 11-11 | .500 | - | ESPN+ | Fertitta Center · Houston, TX |
| 23 | Sun Feb 9 | vs Arizona St | W86-73 | 12-11 | .522 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 24 | Wed Feb 12 | at TCU | L72-73 | 12-12 | .500 | - | CBS | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 25 | Sat Feb 15 | vs#12Texas Tech | L55-93 | 12-13 | .480 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 26 | Wed Feb 19 | vs UCF | W104-95 | 13-13 | .500 | - | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
#23Kansas
#8Iowa State
Baylor
Cincinnati