| 4 | Sun Nov 16 | at #22Auburn | 3:00 PM | 3-0 | 1.000 | #1 | ESPN | Neville Arena · Auburn, AL |
| 5 | Thu Nov 20 | vsRider | 9:00 PM | 0-2 | .000 | #1 | TNT | Fertitta Center · Houston, TX |
| 6 | Mon Nov 24 | vsSyracuse | 6:00 PM | 2-0 | 1.000 | #1 | TNT | Fertitta Center · Houston, TX |
| 7 | Tue Nov 25 | vs#20Tennessee | 6:00 PM | 3-0 | 1.000 | #1 | TNT | Fertitta Center · Houston, TX |
| 8 | Sat Dec 6 | vsFlorida St | 8:00 PM | 2-1 | .667 | #1 | Peacock | Fertitta Center · Houston, TX |
| 9 | Wed Dec 10 | vsJackson St | 8:00 PM | 0-2 | .000 | #1 | ESPN+ | Fertitta Center · Houston, TX |
| 10 | Sat Dec 13 | vsNew Orleans | 3:00 PM | 1-1 | .500 | #1 | ESPN+ | Fertitta Center · Houston, TX |
| 11 | Sat Dec 20 | at#21Arkansas | 5:30 PM | 2-1 | .667 | #1 | CBS | Prudential Center · Newark, NJ |
| 12 | Mon Dec 29 | vsMTSU | 8:00 PM | 3-0 | 1.000 | #1 | ESPN+ | Fertitta Center · Houston, TX |
| 13 | Sat Jan 3 | atCincinnati | 2:00 PM | 3-0 | 1.000 | #1 | FOX | Fifth Third Arena · Cincinnati, OH |
| 14 | Tue Jan 6 | vs#11Texas Tech | 9:00 PM | 2-1 | .667 | #1 | FS1 | Fertitta Center · Houston, TX |
| 15 | Sat Jan 10 | atBaylor | 1:00 PM | 2-0 | 1.000 | #1 | Peacock | Ferrell Center · Waco, TX |
| 16 | Tue Jan 13 | vsWest Virginia | 8:30 PM | 3-0 | 1.000 | #1 | FS1 | Fertitta Center · Houston, TX |
| 17 | Sun Jan 18 | vsArizona St | 5:00 PM | 2-0 | 1.000 | #1 | | Fertitta Center · Houston, TX |
| 18 | Sat Jan 24 | at#11Texas Tech | 6:30 PM | 2-1 | .667 | #1 | ESPN | United Supermarkets Arena · Lubbock, TX |
| 19 | Wed Jan 28 | atTCU | 9:00 PM | 2-1 | .667 | #1 | ESPN2 | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 20 | Sat Jan 31 | vsCincinnati | 12:00 PM | 3-0 | 1.000 | #1 | FOX | Fertitta Center · Houston, TX |
| 21 | Wed Feb 4 | vsUCF | 7:00 PM | 2-1 | .667 | #1 | FS1 | Fertitta Center · Houston, TX |
| 22 | Sat Feb 7 | at#7BYU | 10:30 PM | 3-0 | 1.000 | #1 | ESPN | Marriott Center · Provo, UT |
| 23 | Tue Feb 10 | atUtah | 9:00 PM | 3-0 | 1.000 | #1 | | Jon M. Huntsman Center · Salt Lake City, UT |
| 24 | Sat Feb 14 | vsKansas St | 9:00 PM | 2-0 | 1.000 | #1 | Peacock | Fertitta Center · Houston, TX |
| 25 | Mon Feb 16 | at#16Iowa State | 9:00 PM | 3-0 | 1.000 | #1 | ESPN | James H. Hilton Coliseum · Ames, IA |
| 26 | Sat Feb 21 | vs#5Arizona | 3:00 PM | 3-0 | 1.000 | #1 | ABC | Fertitta Center · Houston, TX |
| 27 | Mon Feb 23 | at#25Kansas | 9:00 PM | 2-1 | .667 | #1 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 28 | Sat Feb 28 | vsColorado | 12:00 PM | 2-0 | 1.000 | #1 | | Fertitta Center · Houston, TX |
| 29 | Wed Mar 4 | vsBaylor | 9:00 PM | 2-0 | 1.000 | #1 | ESPN2 | Fertitta Center · Houston, TX |
| 30 | Sat Mar 7 | atOklahoma St | 12:00 PM | 3-0 | 1.000 | #1 | CBS | Gallagher-Iba Arena · Stillwater, OK |
