| 1 | Tue Nov 12 | vs Alabama St | W84-56 | 1-0 | 1.000 | - | ESPNU | Fertitta Center · Houston, TX |
| 2 | Fri Nov 15 | vsBYU | L71-72 | 1-1 | .500 | - | ESPNU | Fertitta Center · Houston, TX |
| 3 | Tue Nov 19 | atRice | W97-89 | 2-1 | .667 | - | | Tudor Fieldhouse · Houston, TX |
| 4 | Fri Nov 22 | at11Oregon | L66-78 | 2-2 | .500 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 5 | Tue Nov 26 | vsHou Christian | W112-73 | 3-2 | .600 | - | | Fertitta Center · Houston, TX |
| 6 | Wed Dec 4 | vsTexas St | W68-60 | 4-2 | .667 | - | | Fertitta Center · Houston, TX |
| 7 | Sun Dec 8 | atSouth Carolina | W76-56 | 5-2 | .714 | - | ESPNU | Colonial Life Arena · Columbia, SC |
| 8 | Wed Dec 11 | vsUT Arlington | W71-63 | 6-2 | .750 | - | | Fertitta Center · Houston, TX |
| 9 | Sun Dec 15 | vsOklahoma St | L55-61 | 6-3 | .667 | - | ESPN | Fertitta Center · Houston, TX |
| 10 | Thu Dec 19 | vsUTEP | W77-57 | 7-3 | .700 | - | | Fertitta Center · Houston, TX |
| 11 | Sun Dec 22 | atPortland | W81-56 | 8-3 | .727 | - | ESPNU | Stan Sheriff Center · Honolulu, HI |
| 12 | Mon Dec 23 | atGeorgia Tech | W70-59 | 9-3 | .750 | - | ESPN2 | Stan Sheriff Center · Honolulu, HI |
| 13 | Wed Dec 25 | atWashington | W75-71 | 10-3 | .769 | - | ESPN2 | Stan Sheriff Center · Honolulu, HI |
| 14 | Fri Jan 3 | vsUCF | W78-63 | 11-3 | .786 | - | ESPN2 | Fertitta Center · Houston, TX |
| 15 | Tue Jan 7 | atTemple | W78-74 | 12-3 | .800 | - | CBSSN | Liacouras Center · Philadelphia, PA |
| 16 | Sat Jan 11 | atTulsa | L61-63 | 12-4 | .750 | - | ESPN2 | Donald W. Reynolds Center · Tulsa, OK |
| 17 | Wed Jan 15 | vsSMU | W71-62 | 13-4 | .765 | - | CBSSN | Fertitta Center · Houston, TX |
| 18 | Sat Jan 18 | at16Wichita St | W65-54 | 14-4 | .778 | - | ESPN2 | Charles Koch Arena · Wichita, KS |
| 19 | Thu Jan 23 | vsUConn | W63-59 | 15-4 | .789 | #25 | ESPNU | Fertitta Center · Houston, TX |
| 20 | Sun Jan 26 | vsSouth Florida | W68-49 | 16-4 | .800 | #25 | CBSSN | Fertitta Center · Houston, TX |
| 21 | Wed Jan 29 | atE Carolina | W69-59 | 17-4 | .810 | #21 | | Williams Arena at Minges Coliseum · Greenville, NC |
| 22 | Sat Feb 1 | atCincinnati | L62-64 | 17-5 | .773 | #21 | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 23 | Thu Feb 6 | vsTulane | W75-62 | 18-5 | .783 | #25 | ESPNU | Fertitta Center · Houston, TX |
| 24 | Sun Feb 9 | vsWichita St | W76-43 | 19-5 | .792 | #25 | ESPN | Fertitta Center · Houston, TX |
| 25 | Wed Feb 12 | atSouth Florida | W62-58 | 20-5 | .800 | #20 | ESPNU | Yuengling Center · Tampa, FL |
| 26 | Sat Feb 15 | atSMU | L72-73 (OT) | 20-6 | .769 | #20 | ESPNU | Moody Coliseum · Dallas, TX |
| 27 | Wed Feb 19 | vsTulsa | W76-43 | 21-6 | .778 | #22 | ESPNU | Fertitta Center · Houston, TX |
| 28 | Sat Feb 22 | atMemphis | L59-60 | 21-7 | .750 | #22 | ESPN2 | FedExForum · Memphis, TN |
| 29 | Sun Mar 1 | vsCincinnati | W68-55 | 22-7 | .759 | #25 | ESPN | Fertitta Center · Houston, TX |
| 30 | Thu Mar 5 | atUConn | L71-77 | 22-8 | .733 | #21 | CBSSN | Gampel Pavilion · Storrs, CT |
| 31 | Sun Mar 8 | vsMemphis | W64-57 | 23-8 | .742 | #21 | CBS | Fertitta Center · Houston, TX |
