| 1 | Mon Nov 7 | vs N Colorado | W83-36 | 1-0 | 1.000 | #3 | | Fertitta Center · Houston, TX |
| 2 | Fri Nov 11 | at Saint Joseph's | W81-55 | 2-0 | 1.000 | - | CBS | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 3 | Mon Nov 14 | vs Oral Roberts | W83-45 | 3-0 | 1.000 | - | | Fertitta Center · Houston, TX |
| 4 | Wed Nov 16 | vs Texas So | W83-48 | 4-0 | 1.000 | - | | Fertitta Center · Houston, TX |
| 5 | Sun Nov 20 | at Oregon | W66-56 | 5-0 | 1.000 | #3 | ESPN | Matthew Knight Arena · Eugene, OR |
| 6 | Sat Nov 26 | vs Kent State | W49-44 | 6-0 | 1.000 | #2 | | Fertitta Center · Houston, TX |
| 7 | Tue Nov 29 | vs Norfolk St | W100-52 | 7-0 | 1.000 | #1 | | Fertitta Center · Houston, TX |
| 8 | Sat Dec 3 | vs Saint Mary's | W53-48 | 8-0 | 1.000 | - | ESPN2 | Fertitta Center · Houston, TX |
| 9 | Tue Dec 6 | vs North Florida | W76-42 | 9-0 | 1.000 | #1 | | Fertitta Center · Houston, TX |
| 10 | Sat Dec 10 | vs #8Alabama | L65-71 | 9-1 | .900 | #1 | ABC | Fertitta Center · Houston, TX |
| 11 | Tue Dec 13 | vs NC A&T | W74-46 | 10-1 | .909 | #5 | | Fertitta Center · Houston, TX |
| 12 | Sat Dec 17 | at #2Virginia | W69-61 | 11-1 | .917 | #5 | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 13 | Wed Dec 21 | vs McNeese | W83-44 | 12-1 | .923 | #3 | | Fertitta Center · Houston, TX |
| 14 | Wed Dec 28 | at Tulsa | W89-50 | 13-1 | .929 | #3 | ESPNU | Donald W. Reynolds Center · Tulsa, OK |
| 15 | Sat Dec 31 | vs UCF | W71-65 | 14-1 | .933 | #3 | | Fertitta Center · Houston, TX |
| 16 | Thu Jan 5 | vs SMU | W87-53 | 15-1 | .938 | #2 | ESPN2 | Fertitta Center · Houston, TX |
| 17 | Sun Jan 8 | at Cincinnati | W72-59 | 16-1 | .941 | #2 | ESPN | Fifth Third Arena · Cincinnati, OH |
| 18 | Wed Jan 11 | vs South Florida | W83-77 | 17-1 | .944 | #1 | | Fertitta Center · Houston, TX |
| 19 | Tue Jan 17 | at Tulane | W80-60 | 18-1 | .947 | #1 | | Devlin Fieldhouse · New Orleans, LA |
| 20 | Sun Jan 22 | vs Temple | L55-56 | 18-2 | .900 | #1 | ESPN | Fertitta Center · Houston, TX |
| 21 | Wed Jan 25 | atUCF | W82-71 | 19-2 | .905 | #3 | | Addition Financial Arena · Orlando, FL |
| 22 | Sat Jan 28 | vsCincinnati | W75-69 | 20-2 | .909 | #3 | CBS | Fertitta Center · Houston, TX |
| 23 | Thu Feb 2 | at Wichita St | W70-61 | 21-2 | .913 | #3 | ESPN2 | Charles Koch Arena · Wichita, KS |
| 24 | Sun Feb 5 | atTemple | W81-65 | 22-2 | .917 | #3 | ESPN2 | Liacouras Center · Philadelphia, PA |
| 25 | Wed Feb 8 | vsTulsa | W80-42 | 23-2 | .920 | #2 | | Fertitta Center · Houston, TX |
| 26 | Thu Feb 16 | atSMU | W80-65 | 24-2 | .923 | #2 | ESPN2 | Moody Coliseum · Dallas, TX |
| 27 | Sun Feb 19 | vs Memphis | W72-64 | 25-2 | .926 | #2 | ESPN | Fertitta Center · Houston, TX |
| 28 | Wed Feb 22 | vsTulane | W89-59 | 26-2 | .929 | #1 | ESPNU | Fertitta Center · Houston, TX |
| 29 | Sat Feb 25 | at E Carolina | W76-57 | 27-2 | .931 | #1 | ESPN2 | Williams Arena at Minges Coliseum · Greenville, NC |
| 30 | Thu Mar 2 | vsWichita St | W83-66 | 28-2 | .933 | #1 | ESPN2 | Fertitta Center · Houston, TX |
| 31 | Sun Mar 5 | atMemphis | W67-65 | 29-2 | .935 | #1 | CBS | FedExForum · Memphis, TN |
| 32 | Fri Mar 10 | vsE Carolina | W60-46 | 30-2 | .938 | - | ESPN2 | Fertitta Center · Houston, TX |
| 33 | Sat Mar 11 | vsCincinnati | W69-48 | 31-2 | .939 | - | ESPN2 | Fertitta Center · Houston, TX |
| 34 | Sun Mar 12 | vsMemphis | L65-75 | 31-3 | .912 | - | ESPN | Fertitta Center · Houston, TX |
| 35 | Thu Mar 16 | vs #16N Kentucky | W63-52 | 32-3 | .914 | #1 | TNT | Fertitta Center · Houston, TX |
| 36 | Sat Mar 18 | vs #9Auburn | W81-64 | 33-3 | .917 | #1 | TBS | Fertitta Center · Houston, TX |
| 37 | Fri Mar 24 | vs #5Miami | L75-89 | 33-4 | .892 | #1 | CBS | Fertitta Center · Houston, TX |
