| 1 | Mon Nov 3 | vs Lehigh | W75-57 | 1-0 | 1.000 | #2 | CBSSN | Fertitta Center · Houston, TX |
| 2 | Sat Nov 8 | vsTowson | W65-48 | 2-0 | 1.000 | #2 | ESPN+ | Fertitta Center · Houston, TX |
| 3 | Wed Nov 12 | vsOakland | W78-45 | 3-0 | 1.000 | #1 | ESPN+ | Fertitta Center · Houston, TX |
| 4 | Sun Nov 16 | at22Auburn | W73-72 | 4-0 | 1.000 | #1 | ESPN | Neville Arena · Auburn, AL |
| 5 | Thu Nov 20 | vsRider | W91-45 | 5-0 | 1.000 | #2 | TNT | Fertitta Center · Houston, TX |
| 6 | Mon Nov 24 | vsSyracuse | W78-74 (OT) | 6-0 | 1.000 | #3 | TNT | Fertitta Center · Houston, TX |
| 7 | Tue Nov 25 | vs17Tennessee | L73-76 | 6-1 | .857 | #3 | TNT | Fertitta Center · Houston, TX |
| 8 | Wed Nov 26 | vsNotre Dame | W66-56 | 7-1 | .875 | #3 | TNT | Fertitta Center · Houston, TX |
| 9 | Sat Dec 6 | vsFlorida St | W82-67 | 8-1 | .889 | #8 | Peacock | Fertitta Center · Houston, TX |
| 10 | Wed Dec 10 | vsJackson St | W80-38 | 9-1 | .900 | #7 | ESPN+ | Fertitta Center · Houston, TX |
| 11 | Sat Dec 13 | vsNew Orleans | W99-57 | 10-1 | .909 | #7 | ESPN+ | Fertitta Center · Houston, TX |
| 12 | Sat Dec 20 | at14Arkansas | W94-85 | 11-1 | .917 | #8 | CBS | Prudential Center · Newark, NJ |
| 13 | Mon Dec 29 | vsMTSU | W69-60 | 12-1 | .923 | #8 | ESPN+ | Fertitta Center · Houston, TX |
| 14 | Sat Jan 3 | atCincinnati | W67-60 | 13-1 | .929 | #8 | FOX | Fifth Third Arena · Cincinnati, OH |
| 15 | Tue Jan 6 | vs14Texas Tech | W69-65 | 14-1 | .933 | #7 | FS1 | Fertitta Center · Houston, TX |
| 16 | Sat Jan 10 | atBaylor | W77-55 | 15-1 | .938 | #7 | Peacock | Ferrell Center · Waco, TX |
| 17 | Tue Jan 13 | vsWest Virginia | W77-48 | 16-1 | .941 | #7 | FS1 | Fertitta Center · Houston, TX |
| 18 | Sun Jan 18 | vsArizona St | W103-73 | 17-1 | .944 | #7 | ESPN | Fertitta Center · Houston, TX |
| 19 | Sat Jan 24 | at12Texas Tech | L86-90 | 17-2 | .895 | #6 | ESPN | United Supermarkets Arena · Lubbock, TX |
| 20 | Wed Jan 28 | atTCU | W79-70 | 18-2 | .900 | #10 | ESPN2 | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 21 | Sat Jan 31 | vsCincinnati | W76-54 | 19-2 | .905 | #10 | FOX | Fertitta Center · Houston, TX |
| 22 | Wed Feb 4 | vsUCF | W79-55 | 20-2 | .909 | #8 | FS1 | Fertitta Center · Houston, TX |
| 23 | Sat Feb 7 | at16BYU | W77-66 | 21-2 | .913 | #8 | ESPN | Marriott Center · Provo, UT |
| 24 | Tue Feb 10 | atUtah | W66-52 | 22-2 | .917 | #3 | ESPN | Jon M. Huntsman Center · Salt Lake City, UT |
| 25 | Sat Feb 14 | vsKansas St | W78-64 | 23-2 | .920 | #3 | Peacock | Fertitta Center · Houston, TX |
| 26 | Mon Feb 16 | at6Iowa State | L67-70 | 23-3 | .885 | #2 | ESPN | James H. Hilton Coliseum · Ames, IA |
| 27 | Sat Feb 21 | vs4Arizona | L66-73 | 23-4 | .852 | #2 | ABC | Fertitta Center · Houston, TX |
| 28 | Mon Feb 23 | at14Kansas | L56-69 | 23-5 | .821 | #5 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 29 | Sat Feb 28 | vsColorado | W102-62 | 24-5 | .828 | #5 | ESPN2 | Fertitta Center · Houston, TX |
