| 1 | Mon Nov 3 | vs Lehigh | 8:00 PM | 11-19 | .367 | #2 | CBS | Fertitta Center · Houston, TX |
| 2 | Sat Nov 8 | vsTowson | 3:00 PM | 22-11 | .667 | #2 | ESPN+ | Fertitta Center · Houston, TX |
| 3 | Wed Nov 12 | vsOakland | 8:00 PM | 16-18 | .471 | #2 | ESPN+ | Fertitta Center · Houston, TX |
| 4 | Sun Nov 16 | at#20Auburn | 3:00 PM | 32-6 | .842 | #2 | ESPN | Neville Arena · Auburn, AL |
| 5 | Thu Nov 20 | vsRider | 9:00 PM | 14-19 | .424 | #2 | TNT | Fertitta Center · Houston, TX |
| 6 | Mon Nov 24 | vsSyracuse | 6:00 PM | 14-19 | .424 | #2 | | Fertitta Center · Houston, TX |
| 7 | Tue Nov 25 | vs#18Tennessee | 5:00 PM | 30-8 | .789 | #2 | | Fertitta Center · Houston, TX |
| 8 | Sat Dec 6 | vsFlorida St | 8:00 PM | 17-15 | .531 | #2 | Peacock | Fertitta Center · Houston, TX |
| 9 | Wed Dec 10 | vsJackson St | 8:00 PM | 16-18 | .471 | #2 | ESPN+ | Fertitta Center · Houston, TX |
| 10 | Sat Dec 13 | vsNew Orleans | 3:00 PM | 4-27 | .129 | #2 | ESPN+ | Fertitta Center · Houston, TX |
| 11 | Sat Dec 20 | at#14Arkansas | 5:30 PM | 22-14 | .611 | #2 | CBS | Bud Walton Arena · Fayetteville, AR |
| 12 | Mon Dec 29 | vsMTSU | 8:00 PM | 22-12 | .647 | #2 | ESPN+ | Fertitta Center · Houston, TX |
| 13 | Sat Jan 3 | atCincinnati | 2:00 PM | 19-16 | .543 | #2 | FOX | Fifth Third Arena · Cincinnati, OH |
| 14 | Tue Jan 6 | vs#10Texas Tech | 9:00 PM | 28-9 | .757 | #2 | FS1 | Fertitta Center · Houston, TX |
| 15 | Sat Jan 10 | atBaylor | 1:00 PM | 20-15 | .571 | #2 | Peacock | Ferrell Center · Waco, TX |
| 16 | Tue Jan 13 | vsWest Virginia | 8:30 PM | 19-13 | .594 | #2 | FS1 | Fertitta Center · Houston, TX |
| 17 | Sun Jan 18 | vsArizona St | TBD | 13-20 | .394 | #2 | | Fertitta Center · Houston, TX |
| 18 | Sat Jan 24 | at#10Texas Tech | 6:30 PM | 28-9 | .757 | #2 | ESPN | United Supermarkets Arena · Lubbock, TX |
| 19 | Wed Jan 28 | atTCU | 9:00 PM | 16-16 | .500 | #2 | ESPN2 | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 20 | Sat Jan 31 | vsCincinnati | 12:00 PM | 19-16 | .543 | #2 | FOX | Fertitta Center · Houston, TX |
| 21 | Wed Feb 4 | vsUCF | 7:00 PM | 20-17 | .541 | #2 | FS1 | Fertitta Center · Houston, TX |
| 22 | Sat Feb 7 | at#8BYU | 10:30 PM | 26-10 | .722 | #2 | ESPN | Marriott Center · Provo, UT |
| 23 | Tue Feb 10 | atUtah | 9:00 PM | 16-17 | .485 | #2 | | Jon M. Huntsman Center · Salt Lake City, UT |
| 24 | Sat Feb 14 | vsKansas St | 9:00 PM | 16-17 | .485 | #2 | Peacock | Fertitta Center · Houston, TX |
| 25 | Mon Feb 16 | at#16Iowa State | 9:00 PM | 25-10 | .714 | #2 | ESPN | James H. Hilton Coliseum · Ames, IA |
| 26 | Sat Feb 21 | vs#13Arizona | 3:00 PM | 24-13 | .649 | #2 | ABC | Fertitta Center · Houston, TX |
| 27 | Mon Feb 23 | at#19Kansas | 9:00 PM | 21-13 | .618 | #2 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 28 | Sat Feb 28 | vsColorado | 12:00 PM | 14-21 | .400 | #2 | | Fertitta Center · Houston, TX |
| 29 | Wed Mar 4 | vsBaylor | 9:00 PM | 20-15 | .571 | #2 | ESPN2 | Fertitta Center · Houston, TX |
| 30 | Sat Mar 7 | atOklahoma St | 12:00 PM | 17-18 | .486 | #2 | CBS | Gallagher-Iba Arena · Stillwater, OK |
