| 1 | Mon Nov 4 | vs FAMU | W105-59 | 1-0 | 1.000 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 2 | Fri Nov 8 | vs FGCU | W67-51 | 2-0 | 1.000 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 3 | Tue Nov 12 | vs Texas St | W76-71 | 3-0 | 1.000 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 4 | Fri Nov 15 | at Michigan | L64-76 | 3-1 | .750 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 5 | Tue Nov 19 | vs Alcorn St | W71-48 | 4-1 | .800 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 6 | Thu Nov 28 | vs Santa Clara | L52-69 | 4-2 | .667 | - | truTV | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 7 | Fri Nov 29 | at Colorado St | L72-76 (OT) | 4-3 | .571 | - | | Moby Arena · Fort Collins, CO |
| 8 | Thu Dec 5 | vs Xavier | W76-72 | 5-3 | .625 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 9 | Sun Dec 8 | vs Vanderbilt | L74-83 | 5-4 | .556 | - | ESPNU | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 10 | Mon Dec 16 | vs South Alabama | W58-49 | 6-4 | .600 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 11 | Sun Dec 22 | vs Montana St | W82-48 | 7-4 | .636 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 12 | Mon Dec 30 | at Arizona | L81-90 | 7-5 | .583 | - | ESPN+ | McKale Center · Tucson, AZ |
| 13 | Sat Jan 4 | vs Kansas St | W63-62 | 8-5 | .615 | - | CBS | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 14 | Mon Jan 6 | at #12Houston | L46-65 | 8-6 | .571 | - | ESPN2 | Fertitta Center · Houston, TX |
| 15 | Sat Jan 11 | vs BYU | W71-67 | 9-6 | .600 | - | ESPN2 | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 16 | Wed Jan 15 | vs Utah | L65-73 | 9-7 | .563 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 17 | Sun Jan 19 | at #25Baylor | W74-71 | 10-7 | .588 | - | ESPN | Ferrell Center · Waco, TX |
| 18 | Wed Jan 22 | vs #12Kansas | L61-74 | 10-8 | .556 | - | ESPN2 | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 19 | Sat Jan 25 | at UCF | L58-85 | 10-9 | .526 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 20 | Wed Jan 29 | at #22Texas Tech | L57-71 | 10-10 | .500 | - | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 21 | Sun Feb 2 | vs Colorado | W68-57 | 11-10 | .524 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 22 | Wed Feb 5 | vs West Virginia | W65-60 | 12-10 | .545 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 23 | Sat Feb 8 | at #8Iowa State | L52-82 | 12-11 | .522 | - | ESPN+ | James H. Hilton Coliseum · Ames, IA |
| 24 | Wed Feb 12 | vs Oklahoma St | W73-72 | 13-11 | .542 | - | CBS | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 25 | Sat Feb 15 | at Arizona St | W74-70 | 14-11 | .560 | - | ESPN+ | Desert Financial Arena · Tempe, AZ |
| 26 | Tue Feb 18 | vs#9Texas Tech | W69-66 | 15-11 | .577 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
Cincinnati