| 1 | Mon Nov 3 | vs New Orleans | L74-78 | 0-1 | .000 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 2 | Thu Nov 6 | vsSt Francis PA | W104-63 | 1-1 | .500 | - | TNT | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 3 | Mon Nov 10 | vsLamar | W78-65 | 2-1 | .667 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 4 | Fri Nov 14 | vs6Michigan | L63-67 | 2-2 | .500 | - | ESPN2 | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 5 | Wed Nov 19 | vsKansas City | W81-45 | 3-2 | .600 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 6 | Thu Nov 27 | at10Florida | W84-80 | 4-2 | .667 | - | FS1 | Jenny Craig Pavilion · San Diego, CA |
| 7 | Fri Nov 28 | vsWisconsin | W74-63 | 5-2 | .714 | - | FOX | Jenny Craig Pavilion · San Diego, CA |
| 8 | Fri Dec 5 | vsNotre Dame | L85-87 (OT) | 5-3 | .625 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 9 | Sun Dec 7 | atNorth Texas | W65-55 | 6-3 | .667 | - | ESPN+ | The Super Pit · Denton, TX |
| 10 | Mon Dec 15 | vsIncarnate Word | W69-65 | 7-3 | .700 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 11 | Thu Dec 18 | vsOral Roberts | W72-53 | 8-3 | .727 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 12 | Sun Dec 21 | vsFAMU | W80-56 | 9-3 | .750 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 13 | Mon Dec 29 | vsJackson St | W115-64 | 10-3 | .769 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 14 | Sat Jan 3 | vsBaylor | W69-63 | 11-3 | .786 | - | TNT | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 15 | Tue Jan 6 | at22Kansas | L100-104 (OT) | 11-4 | .733 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 16 | Sat Jan 10 | vs1Arizona | L73-86 | 11-5 | .688 | - | ESPN | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 17 | Wed Jan 14 | at11BYU | L70-76 | 11-6 | .647 | - | ESPN2 | Marriott Center · Provo, UT |
| 18 | Sat Jan 17 | atUtah | L79-82 | 11-7 | .611 | - | TNT | Jon M. Huntsman Center · Salt Lake City, UT |
| 19 | Tue Jan 20 | vsOklahoma St | W68-65 | 12-7 | .632 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 20 | Sat Jan 24 | atBaylor | W97-90 | 13-7 | .650 | - | ESPN | Ferrell Center · Waco, TX |
| 21 | Wed Jan 28 | vs10Houston | L70-79 | 13-8 | .619 | - | ESPN2 | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 22 | Sun Feb 1 | atColorado | L61-87 | 13-9 | .591 | - | TNT | CU Events Center · Boulder, CO |
| 23 | Sat Feb 7 | vsKansas St | W84-82 | 14-9 | .609 | - | TNT | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 24 | Tue Feb 10 | vs5Iowa State | W62-55 | 15-9 | .625 | - | FS1 | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 25 | Sat Feb 14 | atOklahoma St | W95-92 (OT) | 16-9 | .640 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 26 | Tue Feb 17 | atUCF | L71-82 | 16-10 | .615 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 27 | Sat Feb 21 | vsWest Virginia | W60-54 | 17-10 | .630 | - | Peacock | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 28 | Tue Feb 24 | vsArizona St | W90-78 | 18-10 | .643 | - | CBSSN | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 29 | Sat Feb 28 | atKansas St | W77-68 | 19-10 | .655 | - | ESPN2 | Bramlage Coliseum · Manhattan, KS |
