| 1 | Thu Nov 11 | vs McNeese | W77-61 | 1-0 | 1.000 | - | | Schollmaier Arena · Fort Worth, TX |
| 2 | Mon Nov 15 | vsSouthern Miss | W83-51 | 2-0 | 1.000 | - | | Schollmaier Arena · Fort Worth, TX |
| 3 | Thu Nov 18 | vsNicholls | W63-50 | 3-0 | 1.000 | - | | Schollmaier Arena · Fort Worth, TX |
| 4 | Mon Nov 22 | vsSanta Clara | L66-85 | 3-1 | .750 | - | CBSSN | Schollmaier Arena · Fort Worth, TX |
| 5 | Wed Nov 24 | atPepperdine | W73-64 | 4-1 | .800 | - | CBSSN | Firestone Fieldhouse · Malibu, CA |
| 6 | Mon Nov 29 | vsAustin Peay | W68-51 | 5-1 | .833 | - | | Schollmaier Arena · Fort Worth, TX |
| 7 | Thu Dec 2 | vsOral Roberts | W71-63 | 6-1 | .857 | - | | Schollmaier Arena · Fort Worth, TX |
| 8 | Wed Dec 8 | vsUtah | W76-62 | 7-1 | .875 | - | | Schollmaier Arena · Fort Worth, TX |
| 9 | Sat Dec 11 | atTexas A&M | W68-64 | 8-1 | .889 | - | SEC Network | Toyota Center · Houston, TX |
| 10 | Sat Dec 18 | atGeorgetown | W80-73 | 9-1 | .900 | - | FS1 | Capital One Arena · Washington, D.C. |
| 11 | Tue Dec 21 | vsGrambling | W90-55 | 10-1 | .909 | - | | Schollmaier Arena · Fort Worth, TX |
| 13 | Mon Jan 3 | vsWest Virginia | PPD | 21-13 | .618 | - | | Schollmaier Arena · Fort Worth, TX |
| 14 | Sat Jan 8 | vs1Baylor | L64-76 | 10-2 | .833 | - | | Schollmaier Arena · Fort Worth, TX |
| 15 | Wed Jan 12 | atKansas St | W60-57 | 11-2 | .846 | - | ESPNU | Bramlage Coliseum · Manhattan, KS |
| 16 | Sat Jan 15 | vsOklahoma | W59-58 (OT) | 12-2 | .857 | - | ESPN2 | Schollmaier Arena · Fort Worth, TX |
| 17 | Wed Jan 19 | atOklahoma St | L56-57 | 12-3 | .800 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 18 | Sat Jan 22 | at15Iowa State | W59-44 | 13-3 | .813 | - | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 19 | Tue Jan 25 | vsTexas | L50-73 | 13-4 | .765 | - | ESPNU | Schollmaier Arena · Fort Worth, TX |
| 20 | Sat Jan 29 | vsLSU | W77-68 | 14-4 | .778 | - | ESPN2 | Schollmaier Arena · Fort Worth, TX |
| 21 | Mon Jan 31 | atOklahoma | W72-63 | 15-4 | .789 | - | ESPN2 | Lloyd Noble Center · Norman, OK |
| 22 | Sat Feb 5 | vsKansas St | L63-75 | 15-5 | .750 | - | ESPNU | Schollmaier Arena · Fort Worth, TX |
| 23 | Tue Feb 8 | vsOklahoma St | W77-73 | 16-5 | .762 | - | ESPNU | Schollmaier Arena · Fort Worth, TX |
| 24 | Sat Feb 12 | at9Texas Tech | L69-82 | 16-6 | .727 | - | | United Supermarkets Arena · Lubbock, TX |
| 25 | Tue Feb 15 | vsIowa State | L51-54 | 16-7 | .696 | - | ESPNU | Schollmaier Arena · Fort Worth, TX |
| 26 | Sat Feb 19 | at7Baylor | L62-72 | 16-8 | .667 | - | ESPN2 | Ferrell Center · Waco, TX |
| 27 | Mon Feb 21 | vsWest Virginia | W77-67 | 17-8 | .680 | - | | Schollmaier Arena · Fort Worth, TX |
| 28 | Wed Feb 23 | at20Texas | L66-75 | 17-9 | .654 | - | ESPN2 | Moody Center · Austin, TX |
| 29 | Sat Feb 26 | vs9Texas Tech | W69-66 | 18-9 | .667 | - | ESPN2 | Schollmaier Arena · Fort Worth, TX |
| 30 | Tue Mar 1 | vs6Kansas | W74-64 | 19-9 | .679 | - | | Schollmaier Arena · Fort Worth, TX |
| 31 | Thu Mar 3 | at6Kansas | L68-72 | 19-10 | .655 | - | | Allen Fieldhouse · Lawrence, KS |
| 32 | Sat Mar 5 | atWest Virginia | L64-70 | 19-11 | .633 | - | | WVU Coliseum · Morgantown, WV |
| 33 | Thu Mar 10 | atTexas | W65-60 | 20-11 | .645 | - | ESPN2 | T-Mobile Center · Kansas City, MOS |
| 34 | Fri Mar 11 | atKansas | L62-75 | 20-12 | .625 | - | ESPN2 | T-Mobile Center · Kansas City, MOS |
| 34 | Fri Mar 18 | at8Seton Hall | W69-42 | 21-12 | .636 | #9 | truTV | Viejas Arena · San Diego, CA |
| 35 | Sun Mar 20 | at1Arizona | L80-85 (OT) | 21-13 | .618 | #9 | TBS | Viejas Arena · San Diego, CA |
