| 1 | Mon Nov 3 | vs Morgan St | W87-70 | 1-0 | 1.000 | - | ESPN+ | Capital One Arena · Washington, D.C. |
| 2 | Fri Nov 7 | atMaryland | W70-60 | 2-0 | 1.000 | - | FS1 | XFINITY Center · College Park, MD |
| 3 | Wed Nov 12 | vsBinghamton | W83-70 | 3-0 | 1.000 | - | ESPN+ | Capital One Arena · Washington, D.C. |
| 4 | Sat Nov 15 | vsClemson | W79-74 | 4-0 | 1.000 | - | Peacock | Capital One Arena · Washington, D.C. |
| 5 | Sat Nov 22 | vsWagner | W92-75 | 5-0 | 1.000 | - | ESPN+ | Capital One Arena · Washington, D.C. |
| 6 | Thu Nov 27 | atDayton | L79-84 (OT) | 5-1 | .833 | - | ESPN2 | UD Arena · Dayton, OH |
| 7 | Fri Nov 28 | vsMiami | L65-78 | 5-2 | .714 | - | ESPN | Capital One Arena · Washington, D.C. |
| 8 | Wed Dec 3 | vsUMBC | W90-81 | 6-2 | .750 | - | truTV | Capital One Arena · Washington, D.C. |
| 9 | Sun Dec 7 | at16UNC | L61-81 | 6-3 | .667 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 10 | Sat Dec 13 | vsSaint Peter's | W76-68 (OT) | 7-3 | .700 | - | ESPN+ | Capital One Arena · Washington, D.C. |
| 11 | Wed Dec 17 | atMarquette | W78-69 | 8-3 | .727 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 12 | Sat Dec 20 | vsXavier | L77-80 | 8-4 | .667 | - | FS1 | Capital One Arena · Washington, D.C. |
| 13 | Mon Dec 22 | vsCoppin St | W97-67 | 9-4 | .692 | - | ESPN+ | Capital One Arena · Washington, D.C. |
| 14 | Wed Dec 31 | vsSt John's | L83-95 | 9-5 | .643 | - | FS1 | Capital One Arena · Washington, D.C. |
| 15 | Tue Jan 6 | atDePaul | L50-56 | 9-6 | .600 | - | truTV | Wintrust Arena · Chicago, IL |
| 16 | Sat Jan 10 | vsSeton Hall | L67-76 | 9-7 | .563 | - | FS1 | Capital One Arena · Washington, D.C. |
| 17 | Tue Jan 13 | atCreighton | L83-86 (OT) | 9-8 | .529 | - | Peacock | CHI Health Center Omaha · Omaha, NE |
| 18 | Sat Jan 17 | vs3UConn | L62-64 | 9-9 | .500 | - | FOX | Capital One Arena · Washington, D.C. |
| 19 | Wed Jan 21 | atVillanova | L51-66 | 9-10 | .474 | - | Peacock | Finneran Pavilion · Villanova, PA |
| 20 | Sat Jan 24 | atProvidence | W81-78 | 10-10 | .500 | - | TNT | Amica Mutual Pavilion · Providence, RI |
| 21 | Wed Jan 28 | vsDePaul | W70-61 | 11-10 | .524 | - | FS1 | Capital One Arena · Washington, D.C. |
| 22 | Sat Jan 31 | atButler | W77-64 | 12-10 | .545 | - | TNT | Hinkle Fieldhouse · Indianapolis, IN |
| 23 | Wed Feb 4 | vsCreighton | W76-68 | 13-10 | .565 | - | Peacock | Capital One Arena · Washington, D.C. |
| 24 | Sat Feb 7 | vsVillanova | L73-80 | 13-11 | .542 | - | TNT | Capital One Arena · Washington, D.C. |
| 25 | Sat Feb 14 | at6UConn | L75-79 | 13-12 | .520 | - | Peacock | Gampel Pavilion · Storrs, CT |
| 26 | Wed Feb 18 | vsButler | L89-93 | 13-13 | .500 | - | FS1 | Capital One Arena · Washington, D.C. |
| 27 | Sat Feb 21 | atSeton Hall | L47-51 | 13-14 | .481 | - | FS1 | Prudential Center · Newark, NJ |
| 28 | Tue Feb 24 | vsMarquette | L60-76 | 13-15 | .464 | - | Peacock | Capital One Arena · Washington, D.C. |
| 29 | Sat Feb 28 | atXavier | L84-91 | 13-16 | .448 | - | TNT | Cintas Center · Cincinnati, OH |
| 30 | Tue Mar 3 | at18St John's | L69-72 | 13-17 | .433 | - | Peacock | Carnesecca Arena · Queens, NY |
| 31 | Sat Mar 7 | vsProvidence | W80-79 | 14-17 | .452 | - | truTV | Capital One Arena · Washington, D.C. |
| 32 | Wed Mar 11 | atDePaul | W63-56 | 15-17 | .469 | - | Peacock | Wintrust Arena · Chicago, IL |
| 33 | Thu Mar 12 | atVillanova | W78-64 | 16-17 | .485 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 34 | Fri Mar 13 | at6UConn | L51-67 | 16-18 | .471 | - | FS1 | Gampel Pavilion · Storrs, CT |
