| 1 | Mon Nov 4 | vs So Indiana | W80-78 (OT) | 1-0 | 1.000 | - | FS1 | Wintrust Arena · Chicago, IL |
| 2 | Thu Nov 7 | vs Prairie View | W92-59 | 2-0 | 1.000 | - | FS1 | Wintrust Arena · Chicago, IL |
| 3 | Mon Nov 11 | vs Mercer | W95-64 | 3-0 | 1.000 | - | FS2 | Wintrust Arena · Chicago, IL |
| 4 | Fri Nov 15 | vs Duquesne | W84-58 | 4-0 | 1.000 | - | FS2 | Wintrust Arena · Chicago, IL |
| 5 | Tue Nov 19 | vs E Illinois | W78-69 | 5-0 | 1.000 | - | FS2 | Wintrust Arena · Chicago, IL |
| 6 | Sat Nov 23 | vs N Illinois | W98-52 | 6-0 | 1.000 | - | FS2 | Wintrust Arena · Chicago, IL |
| 7 | Fri Nov 29 | vs Valparaiso | W89-70 | 7-0 | 1.000 | - | FS1 | Wintrust Arena · Chicago, IL |
| 8 | Wed Dec 4 | at Texas Tech | L62-76 | 7-1 | .875 | - | ESPNU | United Supermarkets Arena · Lubbock, TX |
| 9 | Tue Dec 10 | vs Providence | L63-70 (OT) | 7-2 | .778 | - | FS1 | Wintrust Arena · Chicago, IL |
| 10 | Sat Dec 14 | vs Wichita St | W91-72 | 8-2 | .800 | - | FS1 | Wintrust Arena · Chicago, IL |
| 11 | Tue Dec 17 | at St John's | L61-89 | 8-3 | .727 | - | Peacock | Carnesecca Arena · Queens, NY |
| 12 | Sat Dec 21 | at Northwestern | L64-84 | 8-4 | .667 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 13 | Sat Dec 28 | vs Loyola MD | W84-65 | 9-4 | .692 | - | FS1 | Wintrust Arena · Chicago, IL |
| 14 | Wed Jan 1 | vs #11UConn | L68-81 | 9-5 | .643 | - | CBS | Wintrust Arena · Chicago, IL |
| 15 | Sat Jan 4 | at Villanova | L56-100 | 9-6 | .600 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 16 | Wed Jan 8 | at Seton Hall | L80-85 (OT) | 9-7 | .563 | - | Peacock | Prudential Center · Newark, NJ |
| 17 | Sat Jan 11 | vs Xavier | L63-77 | 9-8 | .529 | - | FS1 | Wintrust Arena · Chicago, IL |
| 18 | Tue Jan 14 | vs #7Marquette | L83-85 (OT) | 9-9 | .500 | - | CBS | Wintrust Arena · Chicago, IL |
| 19 | Fri Jan 17 | at Georgetown | W73-68 | 10-9 | .526 | - | CBS | Capital One Arena · Washington, D.C. |
| 20 | Tue Jan 21 | vs Creighton | L49-73 | 10-10 | .500 | - | FS1 | Wintrust Arena · Chicago, IL |
| 21 | Sat Jan 25 | at Butler | L69-86 | 10-11 | .476 | - | CBS | Hinkle Fieldhouse · Indianapolis, IN |
| 22 | Wed Jan 29 | at#25UConn | L61-72 | 10-12 | .455 | - | Peacock | Gampel Pavilion · Storrs, CT |
| 23 | Sun Feb 2 | vsSeton Hall | W74-57 | 11-12 | .478 | - | FS1 | Wintrust Arena · Chicago, IL |
| 24 | Wed Feb 5 | vsVillanova | L49-59 | 11-13 | .458 | - | CBS | Wintrust Arena · Chicago, IL |
| 25 | Tue Feb 11 | at#18Marquette | L58-68 | 11-14 | .440 | - | Peacock | Fiserv Forum · Milwaukee, WI |
| 26 | Sat Feb 15 | atXavier | L68-85 | 11-15 | .423 | - | FS1 | Cintas Center · Cincinnati, OH |
| 27 | Wed Feb 19 | vs#10St John's | L58-82 | 11-16 | .407 | - | FS1 | Wintrust Arena · Chicago, IL |
