| 1 | Mon Nov 4 | vs Stony Brook | W102-62 | 1-0 | 1.000 | #18 | FS1 | Fiserv Forum · Milwaukee, WI |
| 2 | Fri Nov 8 | vs George Mason | W82-63 | 2-0 | 1.000 | #18 | Peacock | Fiserv Forum · Milwaukee, WI |
| 3 | Mon Nov 11 | vs C Michigan | W70-62 | 3-0 | 1.000 | #15 | FS1 | Fiserv Forum · Milwaukee, WI |
| 4 | Fri Nov 15 | at Maryland | W78-74 | 4-0 | 1.000 | #15 | FS1 | XFINITY Center · College Park, MD |
| 5 | Tue Nov 19 | vs #6Purdue | W76-58 | 5-0 | 1.000 | #15 | FS1 | Fiserv Forum · Milwaukee, WI |
| 6 | Sat Nov 23 | vs Georgia | W80-69 | 6-0 | 1.000 | #15 | | Fiserv Forum · Milwaukee, WI |
| 7 | Wed Nov 27 | vs Stonehill | W94-59 | 7-0 | 1.000 | #10 | FS2 | Fiserv Forum · Milwaukee, WI |
| 8 | Sat Nov 30 | vs W Carolina | W94-62 | 8-0 | 1.000 | #10 | FS2 | Fiserv Forum · Milwaukee, WI |
| 9 | Wed Dec 4 | at #6Iowa State | L70-81 | 8-1 | .889 | #5 | ESPN+ | James H. Hilton Coliseum · Ames, IA |
| 10 | Sat Dec 7 | vs #11Wisconsin | W88-74 | 9-1 | .900 | #5 | FOX | Fiserv Forum · Milwaukee, WI |
| 11 | Sat Dec 14 | at Dayton | L63-71 | 9-2 | .818 | #6 | CBS | UD Arena · Dayton, OH |
| 12 | Wed Dec 18 | vs Butler | W80-70 | 10-2 | .833 | #9 | FS1 | Fiserv Forum · Milwaukee, WI |
| 13 | Sat Dec 21 | at Xavier | W72-70 | 11-2 | .846 | #9 | FOX | Cintas Center · Cincinnati, OH |
| 14 | Tue Dec 31 | at Providence | W78-50 | 12-2 | .857 | #8 | FS1 | Amica Mutual Pavilion · Providence, RI |
| 15 | Fri Jan 3 | vs Creighton | W79-71 | 13-2 | .867 | #8 | FS1 | Fiserv Forum · Milwaukee, WI |
| 16 | Tue Jan 7 | vs Georgetown | W74-66 | 14-2 | .875 | #7 | CBS | Fiserv Forum · Milwaukee, WI |
| 17 | Tue Jan 14 | at DePaul | W85-83 (OT) | 15-2 | .882 | #7 | CBS | Wintrust Arena · Chicago, IL |
| 18 | Sat Jan 18 | vsXavier | L57-59 | 15-3 | .833 | #7 | FOX | Fiserv Forum · Milwaukee, WI |
| 19 | Tue Jan 21 | at Seton Hall | W76-59 | 16-3 | .842 | #10 | Peacock | Prudential Center · Newark, NJ |
| 20 | Fri Jan 24 | vs Villanova | W87-74 | 17-3 | .850 | #10 | FS1 | Fiserv Forum · Milwaukee, WI |
| 21 | Tue Jan 28 | atButler | W78-69 | 18-3 | .857 | #9 | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 22 | Sat Feb 1 | vs #25UConn | L69-77 | 18-4 | .818 | #9 | FOX | Fiserv Forum · Milwaukee, WI |
| 23 | Tue Feb 4 | at #12St John's | L64-70 | 18-5 | .783 | #11 | FS1 | Carnesecca Arena · Queens, NY |
| 24 | Sat Feb 8 | atCreighton | L67-77 | 18-6 | .750 | #11 | FOX | CHI Health Center Omaha · Omaha, NE |
| 25 | Tue Feb 11 | vsDePaul | W68-58 | 19-6 | .760 | #18 | Peacock | Fiserv Forum · Milwaukee, WI |
| 26 | Tue Feb 18 | vsSeton Hall | W80-56 | 20-6 | .769 | #16 | CBS | Fiserv Forum · Milwaukee, WI |
