| 1 | Tue Nov 9 | vs SIUE | W88-77 | 1-0 | 1.000 | - | FS2 | Fiserv Forum · Milwaukee, WI |
| 2 | Fri Nov 12 | vs New Hampshire | W75-70 | 2-0 | 1.000 | - | FS2 | Fiserv Forum · Milwaukee, WI |
| 3 | Mon Nov 15 | vs Illinois | W67-66 | 3-0 | 1.000 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 4 | Thu Nov 18 | at Ole Miss | W78-72 | 4-0 | 1.000 | - | ESPN2 | SJB Pavilion · Oxford, MS |
| 5 | Fri Nov 19 | at West Virginia | W82-71 | 5-0 | 1.000 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 6 | Sun Nov 21 | vs St Bonaventure | L54-70 | 5-1 | .833 | - | ESPN | Fiserv Forum · Milwaukee, WI |
| 7 | Sat Nov 27 | vs N Illinois | W80-66 | 6-1 | .857 | - | FS2 | Fiserv Forum · Milwaukee, WI |
| 8 | Tue Nov 30 | vs Jackson St | W83-54 | 7-1 | .875 | - | CBS | Fiserv Forum · Milwaukee, WI |
| 9 | Sat Dec 4 | at #23Wisconsin | L76-89 | 7-2 | .778 | - | FOX | Kohl Center · Madison, WI |
| 10 | Wed Dec 8 | at Kansas St | W64-63 | 8-2 | .800 | - | ESPN2 | Bramlage Coliseum · Manhattan, KS |
| 11 | Sat Dec 11 | vs #4UCLA | L56-67 | 8-3 | .727 | - | FS2 | Fiserv Forum · Milwaukee, WI |
| 12 | Sat Dec 18 | at #22Xavier | L71-80 | 8-4 | .667 | - | FS1 | Cintas Center · Cincinnati, OH |
| 13 | Tue Dec 21 | vs UConn | L70-78 | 8-5 | .615 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 15 | Sat Jan 1 | vs Creighton | L69-75 (2OT) | 8-6 | .571 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 16 | Tue Jan 4 | vs #16Providence | W88-56 | 9-6 | .600 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 17 | Fri Jan 7 | at Georgetown | W92-64 | 10-6 | .625 | - | FS1 | Capital One Arena · Washington, D.C. |
| 18 | Tue Jan 11 | vs DePaul | W87-76 | 11-6 | .647 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 19 | Sat Jan 15 | vs #20Seton Hall | W73-72 | 12-6 | .667 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 20 | Wed Jan 19 | at #11Villanova | W57-54 | 13-6 | .684 | - | CBS | Finneran Pavilion · Villanova, PA |
| 21 | Sun Jan 23 | vs#20Xavier | W75-64 | 14-6 | .700 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 22 | Wed Jan 26 | atSeton Hall | W73-63 | 15-6 | .714 | #22 | FS1 | Prudential Center · Newark, NJ |
| 23 | Sun Jan 30 | at#17Providence | L63-65 | 15-7 | .682 | #22 | FS1 | Amica Mutual Pavilion · Providence, RI |
| 24 | Wed Feb 2 | vs#12Villanova | W83-73 | 16-7 | .696 | #24 | FS1 | Fiserv Forum · Milwaukee, WI |
| 25 | Tue Feb 8 | at#24UConn | L72-80 | 16-8 | .667 | #18 | FS1 | Gampel Pavilion · Storrs, CT |
| 26 | Sat Feb 12 | at Butler | L79-85 | 16-9 | .640 | #18 | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 27 | Wed Feb 16 | vsGeorgetown | W77-66 | 17-9 | .654 | - | FS2 | Fiserv Forum · Milwaukee, WI |
| 28 | Sun Feb 20 | atCreighton | L82-83 | 17-10 | .630 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 29 | Sat Feb 26 | vsButler | W64-56 | 18-10 | .643 | - | FOX | Fiserv Forum · Milwaukee, WI |
| 30 | Wed Mar 2 | atDePaul | L80-91 | 18-11 | .621 | - | CBS | Wintrust Arena · Chicago, IL |
| 31 | Sat Mar 5 | vs St John's | W85-77 | 19-11 | .633 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 32 | Thu Mar 10 | atCreighton | L63-74 | 19-12 | .613 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 33 | Thu Mar 17 | at #8UNC | L63-95 | 19-13 | .594 | #9 | TBS | Dean E. Smith Center · Chapel Hill, NC |
