| 1 | Tue Nov 5 | vs Loyola MD | W88-53 | 1-0 | 1.000 | - | | Fiserv Forum · Milwaukee, WI |
| 2 | Wed Nov 13 | vs Purdue | W65-55 | 2-0 | 1.000 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 3 | Sun Nov 17 | at Wisconsin | L61-77 | 2-1 | .667 | - | FS1 | Kohl Center · Madison, WI |
| 4 | Sat Nov 23 | vs Robert Morris | W66-62 | 3-1 | .750 | - | FS2 | Fiserv Forum · Milwaukee, WI |
| 5 | Thu Nov 28 | vs Davidson | W73-63 | 4-1 | .800 | - | ESPNU | Fiserv Forum · Milwaukee, WI |
| 6 | Fri Nov 29 | vs USC | W101-79 | 5-1 | .833 | - | ESPN2 | Fiserv Forum · Milwaukee, WI |
| 7 | Sun Dec 1 | vs Maryland | L63-84 | 5-2 | .714 | - | ESPN | Fiserv Forum · Milwaukee, WI |
| 8 | Wed Dec 4 | vs Jacksonville | W75-56 | 6-2 | .750 | - | FS2 | Fiserv Forum · Milwaukee, WI |
| 9 | Sat Dec 7 | at Kansas St | W73-65 | 7-2 | .778 | - | ESPN2 | Bramlage Coliseum · Manhattan, KS |
| 10 | Tue Dec 17 | vs Grambling | W93-72 | 8-2 | .800 | - | | Fiserv Forum · Milwaukee, WI |
| 11 | Fri Dec 20 | vs N Dakota St | W82-68 | 9-2 | .818 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 12 | Sat Dec 28 | vs C Arkansas | W106-54 | 10-2 | .833 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 13 | Wed Jan 1 | at Creighton | L75-92 | 10-3 | .769 | - | CBS | CHI Health Center Omaha · Omaha, NE |
| 14 | Sat Jan 4 | vs #10Villanova | W71-60 | 11-3 | .786 | - | FOX | Fiserv Forum · Milwaukee, WI |
| 15 | Tue Jan 7 | vs Providence | L80-81 (OT) | 11-4 | .733 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 16 | Sat Jan 11 | at Seton Hall | L55-69 | 11-5 | .688 | - | CBS | Prudential Center · Newark, NJ |
| 17 | Wed Jan 15 | vs Xavier | W85-65 | 12-5 | .706 | - | | Fiserv Forum · Milwaukee, WI |
| 18 | Sat Jan 18 | at Georgetown | W84-80 | 13-5 | .722 | - | FS1 | Capital One Arena · Washington, D.C. |
| 19 | Tue Jan 21 | vs St John's | W82-68 | 14-5 | .737 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 20 | Fri Jan 24 | at #13Butler | L85-89 (OT) | 14-6 | .700 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 21 | Wed Jan 29 | atXavier | W84-82 (2OT) | 15-6 | .714 | - | FS1 | Cintas Center · Cincinnati, OH |
| 22 | Sat Feb 1 | vs DePaul | W76-72 | 16-6 | .727 | - | | Fiserv Forum · Milwaukee, WI |
| 23 | Sun Feb 9 | vs#19Butler | W76-57 | 17-6 | .739 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 24 | Wed Feb 12 | at#15Villanova | L71-72 | 17-7 | .708 | #18 | FS1 | Finneran Pavilion · Villanova, PA |
| 25 | Tue Feb 18 | vs#15Creighton | L65-73 | 17-8 | .680 | #19 | FS1 | Fiserv Forum · Milwaukee, WI |
| 26 | Sat Feb 22 | atProvidence | L72-84 | 17-9 | .654 | #19 | FOX | Amica Mutual Pavilion · Providence, RI |
| 27 | Wed Feb 26 | vsGeorgetown | W93-72 | 18-9 | .667 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 28 | Sat Feb 29 | vs#13Seton Hall | L79-88 | 18-10 | .643 | - | FOX | Fiserv Forum · Milwaukee, WI |
| 29 | Tue Mar 3 | atDePaul | L68-69 | 18-11 | .621 | - | FS1 | Wintrust Arena · Chicago, IL |
| 30 | Sat Mar 7 | atSt John's | L86-88 | 18-12 | .600 | - | | Carnesecca Arena · Queens, NY |
