| 1 | Mon Nov 4 | vs Texas A&M-CC | W90-73 | 1-0 | 1.000 | #14 | BTN | Mackey Arena · West Lafayette, IN |
| 2 | Fri Nov 8 | vs N Kentucky | W72-50 | 2-0 | 1.000 | #14 | B1G+ | Mackey Arena · West Lafayette, IN |
| 3 | Mon Nov 11 | vs Yale | W92-84 | 3-0 | 1.000 | #13 | BTN | Mackey Arena · West Lafayette, IN |
| 4 | Fri Nov 15 | vs #2Alabama | W87-78 | 4-0 | 1.000 | #13 | Peacock | Mackey Arena · West Lafayette, IN |
| 5 | Tue Nov 19 | at #15Marquette | L58-76 | 4-1 | .800 | #6 | FS1 | Fiserv Forum · Milwaukee, WI |
| 6 | Sat Nov 23 | vs Marshall | W80-45 | 5-1 | .833 | #6 | B1G+ | Mackey Arena · West Lafayette, IN |
| 7 | Thu Nov 28 | vs NC State | W71-61 | 6-1 | .857 | #13 | FS1 | Mackey Arena · West Lafayette, IN |
| 8 | Fri Nov 29 | vs #23Ole Miss | W80-78 | 7-1 | .875 | #13 | | Mackey Arena · West Lafayette, IN |
| 9 | Thu Dec 5 | at Penn State | L70-81 | 7-2 | .778 | #8 | FS1 | Bryce Jordan Center · University Park, PA |
| 10 | Sun Dec 8 | vs Maryland | W83-78 | 8-2 | .800 | #8 | BTN | Mackey Arena · West Lafayette, IN |
| 11 | Sat Dec 14 | vs #17Texas A&M | L66-70 | 8-3 | .727 | #11 | CBS | Mackey Arena · West Lafayette, IN |
| 12 | Sat Dec 21 | at #2Auburn | L69-87 | 8-4 | .667 | #16 | ESPN | Neville Arena · Auburn, AL |
| 13 | Sun Dec 29 | vs Toledo | W83-64 | 9-4 | .692 | #21 | BTN | Mackey Arena · West Lafayette, IN |
| 14 | Thu Jan 2 | at Minnesota | W81-61 | 10-4 | .714 | #20 | FS1 | Williams Arena · Minneapolis, MN |
| 15 | Sun Jan 5 | vs Northwestern | W79-61 | 11-4 | .733 | #20 | BTN | Mackey Arena · West Lafayette, IN |
| 16 | Thu Jan 9 | at Rutgers | W68-50 | 12-4 | .750 | #20 | FS1 | Jersey Mike’s Arena · Piscataway, NJ |
| 17 | Sun Jan 12 | vs Nebraska | W104-68 | 13-4 | .765 | #20 | BTN | Mackey Arena · West Lafayette, IN |
| 18 | Wed Jan 15 | at Washington | W69-58 | 14-4 | .778 | #17 | BTN | Alaska Airlines Arena · Seattle, WA |
| 19 | Sat Jan 18 | at #13Oregon | W65-58 | 15-4 | .789 | #17 | NBC | Matthew Knight Arena · Eugene, OR |
| 20 | Tue Jan 21 | vs Ohio State | L70-73 | 15-5 | .750 | #11 | Peacock | Mackey Arena · West Lafayette, IN |
| 21 | Fri Jan 24 | vs #21Michigan | W91-64 | 16-5 | .762 | #11 | FOX | Mackey Arena · West Lafayette, IN |
| 22 | Fri Jan 31 | vs Indiana | W81-76 | 17-5 | .773 | #10 | FOX | Mackey Arena · West Lafayette, IN |
| 23 | Tue Feb 4 | at Iowa | W90-81 | 18-5 | .783 | #7 | Peacock | Carver-Hawkeye Arena · Iowa City, IA |
| 24 | Fri Feb 7 | vs USC | W90-72 | 19-5 | .792 | #7 | FS1 | Mackey Arena · West Lafayette, IN |
| 25 | Tue Feb 11 | at#20Michigan | L73-75 | 19-6 | .760 | #7 | Peacock | Crisler Center · Ann Arbor, MI |
| 26 | Sat Feb 15 | vs #16Wisconsin | L84-94 | 19-7 | .731 | #7 | CBS | Mackey Arena · West Lafayette, IN |
| 27 | Tue Feb 18 | at #14Michigan St | L66-75 | 19-8 | .704 | #13 | Peacock | Breslin Center · East Lansing, MI |
| 28 | Sun Feb 23 | atIndiana | L58-73 | 19-9 | .679 | #13 | CBS | Simon Skjodt Assembly Hall · Bloomington, IN |
| 29 | Fri Feb 28 | vs UCLA | W76-66 | 20-9 | .690 | #20 | FOX | Mackey Arena · West Lafayette, IN |
| 30 | Tue Mar 4 | vsRutgers | W100-71 | 21-9 | .700 | #18 | Peacock | Mackey Arena · West Lafayette, IN |
| 31 | Fri Mar 7 | at Illinois | L80-88 | 21-10 | .677 | #18 | FOX | State Farm Center · Champaign, IL |
| 32 | Thu Mar 13 | vsUSC | W76-71 | 22-10 | .688 | #20 | BTN | Mackey Arena · West Lafayette, IN |
| 33 | Fri Mar 14 | at#22Michigan | L68-86 | 22-11 | .667 | #20 | BTN | Crisler Center · Ann Arbor, MI |
| 34 | Thu Mar 20 | vs #13High Point | W75-63 | 23-11 | .676 | #4 | truTV | Mackey Arena · West Lafayette, IN |
| 35 | Sat Mar 22 | vs #12McNeese | W76-62 | 24-11 | .686 | #4 | CBS | Mackey Arena · West Lafayette, IN |
