| 1 | Mon Nov 3 | vs Fairfield | W76-68 | 1-0 | 1.000 | - | B1G+ | Bryce Jordan Center · University Park, PA |
| 2 | Sat Nov 8 | atNew Haven | W87-43 | 2-0 | 1.000 | - | | Jeffery P. Hazell Athletics Center |
| 3 | Tue Nov 11 | vsNavy | W80-71 | 3-0 | 1.000 | - | BTN | Bryce Jordan Center · University Park, PA |
| 4 | Sat Nov 15 | atLa Salle | W83-69 | 4-0 | 1.000 | - | Peacock | Tom Gola Arena · Philadelphia, PA |
| 5 | Wed Nov 19 | vsHarvard | W84-80 | 5-0 | 1.000 | - | B1G+ | Bryce Jordan Center · University Park, PA |
| 6 | Sat Nov 22 | vsProvidence | L65-77 | 5-1 | .833 | - | truTV | Bryce Jordan Center · University Park, PA |
| 7 | Tue Nov 25 | vsBoston Univ | W96-87 | 6-1 | .857 | - | Peacock | Bryce Jordan Center · University Park, PA |
| 8 | Sat Nov 29 | vsSacred Heart | W90-59 | 7-1 | .875 | - | Peacock | Bryce Jordan Center · University Park, PA |
| 9 | Tue Dec 2 | vsCampbell | W87-76 | 8-1 | .889 | - | BTN | Bryce Jordan Center · University Park, PA |
| 10 | Tue Dec 9 | atIndiana | L72-113 | 8-2 | .800 | - | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 11 | Sat Dec 13 | vs9Michigan St | L72-76 | 8-3 | .727 | - | BTN | Bryce Jordan Center · University Park, PA |
| 12 | Sun Dec 21 | vsPitt | L46-80 | 8-4 | .667 | - | BTN | Bryce Jordan Center · University Park, PA |
| 13 | Mon Dec 29 | vsNC Central | W90-67 | 9-4 | .692 | - | BTN | Bryce Jordan Center · University Park, PA |
| 14 | Sat Jan 3 | vs20Illinois | L65-73 | 9-5 | .643 | - | BTN | The Palestra · Philadelphia, PA |
| 15 | Tue Jan 6 | vs2Michigan | L72-74 | 9-6 | .600 | - | FS1 | Bryce Jordan Center · University Park, PA |
| 16 | Sat Jan 10 | at5Purdue | L85-93 | 9-7 | .563 | - | BTN | Mackey Arena · West Lafayette, IN |
| 17 | Wed Jan 14 | vsUCLA | L60-71 | 9-8 | .529 | - | FS1 | Bryce Jordan Center · University Park, PA |
| 18 | Sun Jan 18 | atMaryland | L73-96 | 9-9 | .500 | - | BTN | XFINITY Center · College Park, MD |
| 19 | Thu Jan 22 | vsWisconsin | L71-98 | 9-10 | .474 | - | FS1 | Bryce Jordan Center · University Park, PA |
| 20 | Mon Jan 26 | atOhio State | L78-84 | 9-11 | .450 | - | FS1 | Value City Arena · Columbus, OH |
| 21 | Thu Jan 29 | atNorthwestern | L73-94 | 9-12 | .429 | - | Peacock | Welsh-Ryan Arena · Evanston, IL |
| 22 | Sun Feb 1 | vsMinnesota | W77-75 | 10-12 | .455 | - | Peacock | Bryce Jordan Center · University Park, PA |
| 23 | Thu Feb 5 | at2Michigan | L69-110 | 10-13 | .435 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 24 | Sun Feb 8 | vsUSC | L75-77 | 10-14 | .417 | - | BTN | Bryce Jordan Center · University Park, PA |
| 25 | Wed Feb 11 | atWashington | W63-60 | 11-14 | .440 | - | BTN | Alaska Airlines Arena · Seattle, WA |
| 26 | Sat Feb 14 | atOregon | L72-83 | 11-15 | .423 | - | BTN | Matthew Knight Arena · Eugene, OR |
| 27 | Wed Feb 18 | vsRutgers | L72-85 | 11-16 | .407 | - | BTN | Bryce Jordan Center · University Park, PA |
| 28 | Sat Feb 21 | at9Nebraska | L64-87 | 11-17 | .393 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 29 | Sat Feb 28 | vsIowa | W71-69 | 12-17 | .414 | - | BTN | Bryce Jordan Center · University Park, PA |
