| 1 | Mon Nov 3 | at Ohio State | L102-118 | 0-1 | .000 | - | B1G+ | Value City Arena · Columbus, OH |
| 2 | Thu Nov 6 | vsLong Island | L90-94 | 0-2 | .000 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 3 | Sat Nov 8 | atButler | L80-112 | 0-3 | .000 | - | ESPN+ | Hinkle Fieldhouse · Indianapolis, IN |
| 4 | Tue Nov 11 | vsTBD | W121-77 | 1-3 | .250 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 5 | Fri Nov 14 | atE Michigan | W90-83 | 2-3 | .400 | - | ESPN+ | Convocation Center (MI) · Ypsilanti, MI |
| 6 | Tue Nov 18 | atCharleston So | L91-103 | 2-4 | .333 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 7 | Fri Nov 21 | atAlabama St | L80-101 | 2-5 | .286 | - | | Clune Arena · Colorado Springs, CO |
| 8 | Sun Nov 23 | atAir Force | L85-98 | 2-6 | .250 | - | | Clune Arena · Colorado Springs, CO |
| 9 | Sat Nov 29 | vsMorehead St | W85-80 | 3-6 | .333 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 10 | Wed Dec 3 | atDetroit Mercy | L78-92 | 3-7 | .300 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 11 | Sat Dec 6 | vsYoungstown St | L55-78 | 3-8 | .273 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 12 | Thu Dec 11 | vsGreen Bay | L75-85 | 3-9 | .250 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 13 | Tue Dec 16 | vsTBD | W126-73 | 4-9 | .308 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 14 | Mon Dec 22 | atGrand Canyon | L78-91 | 4-10 | .286 | - | | GCU Arena · Phoenix, AZ |
| 15 | Mon Dec 29 | atCleveland St | L86-99 | 4-11 | .267 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 16 | Thu Jan 1 | atN Kentucky | L72-81 | 4-12 | .250 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 17 | Sun Jan 4 | vsWright St | L77-81 | 4-13 | .235 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 18 | Fri Jan 9 | atGreen Bay | L59-75 | 4-14 | .222 | - | ESPN+ | Resch Center · Ashwaubenon, WI |
| 19 | Sun Jan 11 | atMilwaukee | L83-95 | 4-15 | .211 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 20 | Thu Jan 15 | vsRobert Morris | W96-93 (OT) | 5-15 | .250 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 21 | Sat Jan 17 | vsDetroit Mercy | L77-80 | 5-16 | .238 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 22 | Wed Jan 21 | atOakland | W103-85 | 6-16 | .273 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 23 | Sun Jan 25 | vsPurdue FW | PPD | 7-24 | .226 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 24 | Wed Jan 28 | atRobert Morris | L58-74 | 6-17 | .261 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 25 | Fri Jan 30 | atYoungstown St | L76-85 | 6-18 | .250 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 26 | Sat Feb 7 | vsCleveland St | W82-74 | 7-18 | .280 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 27 | Tue Feb 10 | vsMilwaukee | L88-92 | 7-19 | .269 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 28 | Thu Feb 12 | vsN Kentucky | L81-84 | 7-20 | .259 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 29 | Sun Feb 15 | atPurdue FW | L78-83 | 7-21 | .250 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 30 | Thu Feb 19 | atWright St | L73-85 | 7-22 | .241 | - | ESPN+ | Nutter Center · Dayton, OH |
| 31 | Wed Feb 25 | vsOakland | L74-86 | 7-23 | .233 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 32 | Sat Feb 28 | vsPurdue FW | L81-87 | 7-24 | .226 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
