| 1 | Mon Nov 4 | vs TBD | W100-44 | 1-0 | 1.000 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 2 | Fri Nov 8 | at Xavier | L80-94 | 1-1 | .500 | - | FS1 | Cintas Center · Cincinnati, OH |
| 3 | Tue Nov 12 | vsTBD | W97-55 | 2-1 | .667 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 4 | Thu Nov 14 | vs E Michigan | L71-74 | 2-2 | .500 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 5 | Mon Nov 18 | at #5Iowa State | L52-87 | 2-3 | .400 | - | ESPN+ | James H. Hilton Coliseum · Ames, IA |
| 6 | Fri Nov 22 | at Coast Car | L57-71 | 2-4 | .333 | - | | The HTC Center · Conway, SC |
| 7 | Sat Nov 23 | vs SC State | L62-72 | 2-5 | .286 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 8 | Mon Nov 25 | at Alabama A&M | W88-83 | 3-5 | .375 | - | | T.M. Elmore Gymnasium · Normal, AL |
| 9 | Sat Nov 30 | vsTBD | W106-49 | 4-5 | .444 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 10 | Wed Dec 4 | vs Green Bay | W84-75 | 5-5 | .500 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 11 | Sat Dec 7 | vs N Kentucky | L64-66 | 5-6 | .455 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 12 | Wed Dec 11 | at Purdue FW | L76-78 | 5-7 | .417 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 13 | Sat Dec 14 | at Lindenwood | L63-81 | 5-8 | .385 | - | ESPN+ | placeholder · sf, ca |
| 14 | Sat Dec 21 | at FIU | L69-75 | 5-9 | .357 | - | ESPN+ | Ocean Bank Convocation Center · Miami, FL |
| 15 | Sun Dec 29 | at Milwaukee | L81-88 | 5-10 | .333 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 16 | Wed Jan 1 | vs Youngstown St | L61-77 | 5-11 | .313 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 17 | Sat Jan 4 | at Cleveland St | L61-67 | 5-12 | .294 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 18 | Thu Jan 9 | vs Detroit Mercy | W95-61 | 6-12 | .333 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 19 | Wed Jan 15 | at Oakland | L59-72 | 6-13 | .316 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 20 | Sun Jan 19 | vsCleveland St | L62-73 | 6-14 | .300 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 21 | Wed Jan 22 | atGreen Bay | W86-77 | 7-14 | .333 | - | ESPN+ | Resch Center · Ashwaubenon, WI |
| 22 | Sat Jan 25 | vsPurdue FW | L80-91 | 7-15 | .318 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 23 | Thu Jan 30 | at Robert Morris | L53-106 | 7-16 | .304 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 24 | Sat Feb 1 | atYoungstown St | W84-79 | 8-16 | .333 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 25 | Wed Feb 5 | vsMilwaukee | L80-84 (OT) | 8-17 | .320 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 26 | Sat Feb 8 | at Wright St | L73-91 | 8-18 | .308 | - | ESPN+ | Nutter Center · Dayton, OH |
| 27 | Wed Feb 12 | vsOakland | L67-82 | 8-19 | .296 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 28 | Wed Feb 19 | atDetroit Mercy | W80-71 | 9-19 | .321 | - | ESPN+ | Calihan Hall · Detroit, MI |
