| 1 | Mon Nov 3 | at Ohio State | 6:30 PM | 17-15 | .531 | - | B1G+ | Value City Arena · Columbus, OH |
| 2 | Thu Nov 6 | vsLong Island | 6:30 PM | 17-16 | .515 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 3 | Sat Nov 8 | atButler | 5:00 PM | 15-20 | .429 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 4 | Tue Nov 11 | vsTBD | 11:00 AM | 0-0 | .000 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 5 | Fri Nov 14 | atE Michigan | 6:30 PM | 16-16 | .500 | - | ESPN+ | Convocation Center (MI) · Ypsilanti, MI |
| 6 | Tue Nov 18 | atCharleston So | 7:00 PM | 10-22 | .313 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 7 | Fri Nov 21 | atAlabama St | 2:00 PM | 20-16 | .556 | - | | Dunn-Oliver Acadome · Montgomery, AL |
| 8 | Sun Nov 23 | atAir Force | 5:00 PM | 4-28 | .125 | - | | Clune Arena · Colorado Springs, CO |
| 9 | Sat Nov 29 | vsMorehead St | 2:00 PM | 15-17 | .469 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 10 | Wed Dec 3 | atDetroit Mercy | 7:00 PM | 8-24 | .250 | - | | Calihan Hall · Detroit, MI |
| 11 | Sat Dec 6 | vsYoungstown St | 2:00 PM | 21-13 | .618 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 12 | Thu Dec 11 | vsGreen Bay | 6:30 PM | 4-28 | .125 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 13 | Tue Dec 16 | vsTBD | 6:30 PM | 0-0 | .000 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 14 | Mon Dec 22 | atGrand Canyon | TBD | 26-8 | .765 | - | | GCU Arena · Phoenix, AZ |
| 15 | Mon Dec 29 | atCleveland St | 7:00 PM | 23-13 | .639 | - | | Wolstein Center · Cleveland, OH |
| 16 | Thu Jan 1 | atN Kentucky | 2:00 PM | 17-16 | .515 | - | | Truist Arena · Highland Heights, KY |
| 17 | Sun Jan 4 | vsWright St | 2:00 PM | 15-18 | .455 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 18 | Fri Jan 9 | atGreen Bay | 7:00 PM | 4-28 | .125 | - | | Resch Center · Ashwaubenon, WI |
| 19 | Sun Jan 11 | atMilwaukee | TBD | 21-11 | .656 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 20 | Thu Jan 15 | vsRobert Morris | 6:30 PM | 26-9 | .743 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 21 | Sat Jan 17 | vsDetroit Mercy | 2:00 PM | 8-24 | .250 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 22 | Wed Jan 21 | atOakland | 7:00 PM | 16-18 | .471 | - | | Athletics Center O'rena · Rochester, MI |
| 23 | Sun Jan 25 | vsPurdue FW | 2:00 PM | 19-13 | .594 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 24 | Wed Jan 28 | atRobert Morris | 7:00 PM | 26-9 | .743 | - | | UPMC Events Center · Moon Township, PA |
| 25 | Fri Jan 30 | atYoungstown St | 6:30 PM | 21-13 | .618 | - | | Beeghly Center · Youngstown, OH |
| 26 | Sat Feb 7 | vsCleveland St | 2:00 PM | 23-13 | .639 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 27 | Thu Feb 12 | vsN Kentucky | 6:30 PM | 17-16 | .515 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 28 | Sun Feb 15 | atPurdue FW | 2:00 PM | 19-13 | .594 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 29 | Thu Feb 19 | atWright St | TBD | 15-18 | .455 | - | | Nutter Center · Dayton, OH |
| 30 | Wed Feb 25 | vsOakland | 6:30 PM | 16-18 | .471 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 31 | Sat Feb 28 | vsMilwaukee | 2:00 PM | 21-11 | .656 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
