| 1 | Mon Nov 4 | at Michigan | L53-101 | 0-1 | .000 | - | BTN | Crisler Center · Ann Arbor, MI |
| 2 | Wed Nov 6 | vs TBD | W91-53 | 1-1 | .500 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 3 | Sat Nov 9 | at Kansas St | L64-77 | 1-2 | .333 | - | ESPN+ | Bramlage Coliseum · Manhattan, KS |
| 4 | Tue Nov 12 | at Valparaiso | W75-67 | 2-2 | .500 | - | ESPN+ | Athletics-Recreation Center · Valparaiso, IN |
| 5 | Sat Nov 16 | vs E Michigan | W71-63 | 3-2 | .600 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 6 | Tue Nov 19 | at Minnesota | L47-58 | 3-3 | .500 | - | BTN | Williams Arena · Minneapolis, MN |
| 7 | Sat Nov 23 | vs Kent State | L52-68 | 3-4 | .429 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 8 | Tue Nov 26 | vs NJIT | W56-53 | 4-4 | .500 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 9 | Fri Nov 29 | vs Morehead St | L69-71 | 4-5 | .444 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 10 | Thu Dec 5 | at Milwaukee | L67-79 | 4-6 | .400 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 11 | Sat Dec 7 | at Green Bay | W83-61 | 5-6 | .455 | - | ESPN+ | Resch Center · Ashwaubenon, WI |
| 12 | Sat Dec 14 | vsTBD | W103-37 | 6-6 | .500 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 13 | Thu Dec 19 | vs Oakland | W92-75 | 7-6 | .538 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 14 | Sun Dec 22 | vsTBD | W116-60 | 8-6 | .571 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 15 | Sun Dec 29 | vs Wright St | W78-64 | 9-6 | .600 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 16 | Sat Jan 4 | vs IU Indy | W67-61 | 10-6 | .625 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 17 | Wed Jan 8 | at Robert Morris | W80-69 | 11-6 | .647 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 18 | Sat Jan 11 | at Youngstown St | W80-72 | 12-6 | .667 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 19 | Wed Jan 15 | vs N Kentucky | W76-58 | 13-6 | .684 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 20 | Sun Jan 19 | atIU Indy | W73-62 | 14-6 | .700 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 21 | Wed Jan 22 | vs Detroit Mercy | W65-50 | 15-6 | .714 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 22 | Sat Jan 25 | vsGreen Bay | W81-66 | 16-6 | .727 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 23 | Thu Jan 30 | at Purdue FW | W68-58 | 17-6 | .739 | - | ESPNU | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 24 | Wed Feb 5 | atN Kentucky | L75-85 | 17-7 | .708 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 25 | Sat Feb 8 | vsMilwaukee | W77-60 | 18-7 | .720 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 26 | Wed Feb 12 | vsRobert Morris | L59-68 | 18-8 | .692 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 27 | Sun Feb 16 | vsYoungstown St | L60-68 | 18-9 | .667 | - | ESPNU | Wolstein Center · Cleveland, OH |
