| 1 | Mon Nov 6 | at Duquesne | L77-79 | 0-1 | .000 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 2 | Wed Nov 8 | vsTBD | W102-41 | 1-1 | .500 | - | | Wolstein Center · Cleveland, OH |
| 3 | Sat Nov 11 | vsOhio | W82-78 | 2-1 | .667 | - | | Wolstein Center · Cleveland, OH |
| 4 | Wed Nov 15 | vsCanisius | W71-61 | 3-1 | .750 | - | | Wolstein Center · Cleveland, OH |
| 5 | Sat Nov 18 | atE Michigan | L62-69 | 3-2 | .600 | - | | Convocation Center (MI) · Ypsilanti, MI |
| 6 | Wed Nov 22 | vsETSU | W72-70 | 4-2 | .667 | - | | Wolstein Center · Cleveland, OH |
| 7 | Sat Nov 25 | vsAlabama A&M | W86-59 | 5-2 | .714 | - | | Wolstein Center · Cleveland, OH |
| 8 | Wed Nov 29 | atYoungstown St | L69-94 | 5-3 | .625 | - | | Beeghly Center · Youngstown, OH |
| 9 | Sat Dec 2 | vsDetroit Mercy | W69-58 | 6-3 | .667 | - | | Wolstein Center · Cleveland, OH |
| 10 | Tue Dec 5 | atSaint Mary's | L57-70 | 6-4 | .600 | - | | University Credit Union Pavilion · Moraga, CA |
| 11 | Sat Dec 9 | atKent State | L77-83 | 6-5 | .545 | - | | M.A.C. Center · Kent, OH |
| 12 | Fri Dec 15 | atBradley | W76-69 | 7-5 | .583 | - | | Carver Arena · Peoria, IL |
| 13 | Thu Dec 21 | vsW Michigan | W90-77 | 8-5 | .615 | - | | Wolstein Center · Cleveland, OH |
| 14 | Thu Dec 28 | vsOakland | W75-67 | 9-5 | .643 | - | | Wolstein Center · Cleveland, OH |
| 15 | Sun Dec 31 | atIU Indy | W86-77 | 10-5 | .667 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 16 | Thu Jan 4 | atWright St | L70-82 | 10-6 | .625 | - | ESPN2 | Nutter Center · Dayton, OH |
| 17 | Sun Jan 7 | vsN Kentucky | W88-85 (OT) | 11-6 | .647 | - | | Wolstein Center · Cleveland, OH |
| 18 | Fri Jan 12 | atMilwaukee | L80-88 | 11-7 | .611 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 19 | Sun Jan 14 | atGreen Bay | L71-79 | 11-8 | .579 | - | | Resch Center · Ashwaubenon, WI |
| 20 | Sat Jan 20 | vsPurdue FW | W75-68 | 12-8 | .600 | - | | Wolstein Center · Cleveland, OH |
| 21 | Thu Jan 25 | vsWright St | L99-107 (OT) | 12-9 | .571 | - | | Wolstein Center · Cleveland, OH |
| 22 | Sun Jan 28 | vsRobert Morris | W66-64 | 13-9 | .591 | - | | Wolstein Center · Cleveland, OH |
| 23 | Thu Feb 1 | atDetroit Mercy | W77-65 | 14-9 | .609 | - | | Calihan Hall · Detroit, MI |
| 24 | Sat Feb 3 | atOakland | L71-83 | 14-10 | .583 | - | | Athletics Center O'rena · Rochester, MI |
| 25 | Wed Feb 7 | atPurdue FW | W75-72 | 15-10 | .600 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 26 | Wed Feb 14 | vsMilwaukee | L68-71 | 15-11 | .577 | - | | Wolstein Center · Cleveland, OH |
| 27 | Sat Feb 17 | vsYoungstown St | W81-73 | 16-11 | .593 | - | | Wolstein Center · Cleveland, OH |
| 28 | Thu Feb 22 | atN Kentucky | L73-75 | 16-12 | .571 | - | | Truist Arena · Highland Heights, KY |
| 29 | Sun Feb 25 | atRobert Morris | W73-71 | 17-12 | .586 | - | | UPMC Events Center · Moon Township, PA |
| 30 | Wed Feb 28 | vsGreen Bay | L61-69 | 17-13 | .567 | - | | Wolstein Center · Cleveland, OH |
| 31 | Sat Mar 2 | vsIU Indy | W75-66 | 18-13 | .581 | - | | Wolstein Center · Cleveland, OH |
| 32 | Tue Mar 5 | vsIU Indy | W85-66 | 19-13 | .594 | - | | Wolstein Center · Cleveland, OH |
| 33 | Thu Mar 7 | atYoungstown St | W82-70 | 20-13 | .606 | - | | Beeghly Center · Youngstown, OH |
| 34 | Mon Mar 11 | atOakland | L71-74 | 20-14 | .588 | - | ESPNU | Athletics Center O'rena · Rochester, MI |
| 35 | Sun Mar 24 | vsN Colorado | W51-49 | 21-14 | .600 | - | | Wolstein Center · Cleveland, OH |
| 36 | Mon Mar 25 | vsHigh Point | L74-93 | 21-15 | .583 | - | | Wolstein Center · Cleveland, OH |
