| 1 | Mon Nov 4 | at #10Arizona | L64-93 | 0-1 | .000 | - | ESPN+ | McKale Center · Tucson, AZ |
| 2 | Sat Nov 9 | vs St Bonaventure | L78-87 | 0-2 | .000 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 3 | Wed Nov 13 | at Mercyhurst | L52-62 | 0-3 | .000 | - | | Mercyhurst Athletic Center · Erie, PA |
| 4 | Sat Nov 16 | vs SIUE | L58-76 | 0-4 | .000 | - | | Koessler Athletic Center · Buffalo, NY |
| 5 | Sun Nov 17 | at W Michigan | L69-92 | 0-5 | .000 | - | ESPN+ | University Arena (MI) · Kalamazoo, MI |
| 6 | Tue Nov 19 | at Maryland | L37-108 | 0-6 | .000 | - | B1G+ | XFINITY Center · College Park, MD |
| 7 | Sat Nov 23 | vs Brown | L76-83 | 0-7 | .000 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 8 | Wed Nov 27 | at Robert Morris | L64-72 | 0-8 | .000 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 9 | Fri Dec 6 | vs Merrimack | L52-60 | 0-9 | .000 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 10 | Sun Dec 8 | vs Siena | L53-66 | 0-10 | .000 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 11 | Sat Dec 14 | vs Maine | L79-84 | 0-11 | .000 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 12 | Wed Dec 18 | at Loyola Chicago | L60-72 | 0-12 | .000 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 13 | Sat Dec 21 | at Bradley | L59-92 | 0-13 | .000 | - | ESPN+ | Carver Arena · Peoria, IL |
| 14 | Sun Jan 5 | at Sacred Heart | L82-99 | 0-14 | .000 | - | ESPN+ | William H. Pitt Center · Fairfield, CT |
| 15 | Fri Jan 10 | vs Rider | W85-67 | 1-14 | .067 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 16 | Sun Jan 12 | vs Saint Peter's | L49-62 | 1-15 | .063 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 17 | Thu Jan 16 | at Iona | L61-82 | 1-16 | .059 | - | ESPN+ | Hynes Athletics Center · New Rochelle, NY |
| 18 | Sat Jan 18 | at Fairfield | W78-67 | 2-16 | .111 | - | ESPN+ | Leo D. Mahoney Arena · Fairfield, CT |
| 19 | Thu Jan 23 | vsSacred Heart | L84-93 | 2-17 | .105 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 20 | Sat Jan 25 | vs Marist | L47-70 | 2-18 | .100 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 21 | Fri Jan 31 | vs Niagara | L63-64 | 2-19 | .095 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 22 | Thu Feb 6 | at Quinnipiac | L71-89 | 2-20 | .091 | - | ESPN+ | M&T Bank Arena · Hamden, CT |
| 23 | Sat Feb 8 | atMerrimack | L51-69 | 2-21 | .087 | - | ESPN+ | placeholder · sf, ca |
| 24 | Wed Feb 12 | atNiagara | L60-71 | 2-22 | .083 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 25 | Sun Feb 16 | vs Mount St Mary | L66-73 | 2-23 | .080 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
Manhattan