| 1 | Mon Nov 4 | at G Washington | L59-76 | 0-1 | .000 | - | ESPN+ | Charles E. Smith Center · Washington, D.C. |
| 2 | Wed Nov 6 | at Morgan St | W78-73 | 1-1 | .500 | - | | Hill Field House · Baltimore, MD |
| 3 | Sat Nov 9 | vs TBD | W88-62 | 2-1 | .667 | - | | Mercyhurst Athletic Center · Erie, PA |
| 4 | Wed Nov 13 | vs Canisius | W62-52 | 3-1 | .750 | - | | Mercyhurst Athletic Center · Erie, PA |
| 5 | Sat Nov 16 | at Columbia | L63-77 | 3-2 | .600 | - | ESPN+ | Francis S. Levien Gymnasium · New York, NY |
| 6 | Tue Nov 19 | vsTBD | W98-45 | 4-2 | .667 | - | | Mercyhurst Athletic Center · Erie, PA |
| 7 | Sun Nov 24 | at Air Force | L48-82 | 4-3 | .571 | - | | Clune Arena · Colorado Springs, CO |
| 8 | Wed Nov 27 | at California | L55-81 | 4-4 | .500 | - | ESPN+ | Haas Pavilion · Berkeley, CA |
| 9 | Sat Nov 30 | at Sacramento St | W66-60 | 5-4 | .556 | - | ESPN+ | The Nest · Sacramento, CA |
| 10 | Sun Dec 1 | at San Francisco | L59-87 | 5-5 | .500 | - | ESPN+ | War Memorial at the Sobrato Center · San Francisco, CA |
| 11 | Sat Dec 7 | vs Lafayette | L73-77 | 5-6 | .455 | - | | Mercyhurst Athletic Center · Erie, PA |
| 12 | Tue Dec 10 | vsTBD | W77-51 | 6-6 | .500 | - | | Mercyhurst Athletic Center · Erie, PA |
| 13 | Sun Dec 15 | at Kent State | L57-82 | 6-7 | .462 | - | ESPN+ | M.A.C. Center · Kent, OH |
| 14 | Wed Dec 18 | at Binghamton | L60-62 | 6-8 | .429 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 15 | Sun Dec 22 | at West Virginia | L46-67 | 6-9 | .400 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 16 | Fri Jan 3 | vs Stonehill | W76-69 | 7-9 | .438 | - | | Mercyhurst Athletic Center · Erie, PA |
| 17 | Sun Jan 5 | vs C Connecticut | L50-62 | 7-10 | .412 | - | | Mercyhurst Athletic Center · Erie, PA |
| 18 | Fri Jan 10 | at St Francis PA | L59-73 | 7-11 | .389 | - | | DeGol Arena · Loretto, PA |
| 19 | Sun Jan 12 | at Le Moyne | L63-79 | 7-12 | .368 | - | | Ted Grant Court · Syracuse, NY |
| 20 | Sat Jan 18 | at Wagner | W69-65 | 8-12 | .400 | - | | Spiro Sports Center · Staten Island, NY |
| 21 | Mon Jan 20 | at Long Island | L63-72 (OT) | 8-13 | .381 | - | ESPN+ | Steinberg Wellness Center · Brooklyn, NY |
| 22 | Fri Jan 24 | vsWagner | W71-66 | 9-13 | .409 | - | | Mercyhurst Athletic Center · Erie, PA |
| 23 | Sun Jan 26 | vsLong Island | W85-80 (2OT) | 10-13 | .435 | - | | Mercyhurst Athletic Center · Erie, PA |
| 24 | Thu Jan 30 | vsSt Francis PA | W62-58 | 11-13 | .458 | - | | Mercyhurst Athletic Center · Erie, PA |
| 25 | Sat Feb 1 | at Fairleigh | W67-60 | 12-13 | .480 | - | | Stratis Arena at the Rothman Center · Teaneck, NJ |
| 26 | Thu Feb 6 | at Chicago St | L78-85 | 12-14 | .462 | - | | Jones Convocation Center · Chicago, IL |
| 27 | Sat Feb 8 | vsLe Moyne | W82-78 | 13-14 | .481 | - | | Mercyhurst Athletic Center · Erie, PA |
| 28 | Thu Feb 13 | atC Connecticut | L63-73 | 13-15 | .464 | - | | William H. Detrick Gymnasium · New Britain, CT |
| 29 | Sat Feb 15 | atStonehill | L73-85 | 13-16 | .448 | - | ESPN+ | placeholder · sf, ca |
| 30 | Thu Feb 20 | vsFairleigh | W65-60 | 14-16 | .467 | - | | Mercyhurst Athletic Center · Erie, PA |
