| 1 | Mon Nov 3 | vs TBD | W94-50 | 1-0 | 1.000 | - | | Ted Grant Court · Syracuse, NY |
| 2 | Thu Nov 6 | atXavier | L69-74 | 1-1 | .500 | - | ESPN+ | Cintas Center · Cincinnati, OH |
| 3 | Sun Nov 9 | atBowling Green | L60-83 | 1-2 | .333 | - | ESPN+ | Stroh Center · Bowling Green, OH |
| 4 | Thu Nov 13 | atUMass | L80-94 | 1-3 | .250 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 5 | Mon Nov 17 | vsNiagara | W74-68 | 2-3 | .400 | - | | Ted Grant Court · Syracuse, NY |
| 6 | Sat Nov 22 | vsFairfield | L83-97 | 2-4 | .333 | - | | Ted Grant Court · Syracuse, NY |
| 7 | Fri Nov 28 | atLafayette | W76-63 | 3-4 | .429 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 8 | Sat Nov 29 | vsMonmouth | W83-79 | 4-4 | .500 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 9 | Sun Nov 30 | atBall State | L85-96 | 4-5 | .444 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 10 | Sat Dec 6 | atBinghamton | W78-63 | 5-5 | .500 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 11 | Tue Dec 16 | atTexas | L53-95 | 5-6 | .455 | - | SECN+ | Moody Center · Austin, TX |
| 12 | Sat Dec 20 | atSt Bonaventure | L81-92 | 5-7 | .417 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 13 | Sun Dec 28 | atBoston College | L64-72 | 5-8 | .385 | - | ACC Extra | Silvio O. Conte Forum · Chestnut Hill, MA |
| 14 | Fri Jan 2 | atSt Francis PA | W84-58 | 6-8 | .429 | - | | DeGol Arena · Loretto, PA |
| 15 | Sun Jan 4 | atMercyhurst | L60-74 | 6-9 | .400 | - | | Mercyhurst Athletic Center · Erie, PA |
| 16 | Thu Jan 8 | vsNew Haven | W73-47 | 7-9 | .438 | - | | Ted Grant Court · Syracuse, NY |
| 17 | Sat Jan 10 | vsC Connecticut | L59-69 | 7-10 | .412 | - | | Ted Grant Court · Syracuse, NY |
| 18 | Sat Jan 17 | atChicago St | W72-57 | 8-10 | .444 | - | | Jones Convocation Center · Chicago, IL |
| 19 | Mon Jan 19 | vsLong Island | W83-77 | 9-10 | .474 | - | | Ted Grant Court · Syracuse, NY |
| 20 | Fri Jan 23 | vsWagner | W69-67 | 10-10 | .500 | - | | Ted Grant Court · Syracuse, NY |
| 21 | Mon Jan 26 | atFairleigh | W87-74 | 11-10 | .524 | - | | Stratis Arena at the Rothman Center · Teaneck, NJ |
| 22 | Thu Jan 29 | atLong Island | L61-83 | 11-11 | .500 | - | | Steinberg Wellness Center · Brooklyn, NY |
| 23 | Sat Jan 31 | vsStonehill | L54-65 | 11-12 | .478 | - | | Ted Grant Court · Syracuse, NY |
| 24 | Thu Feb 5 | atWagner | L78-79 | 11-13 | .458 | - | | Spiro Sports Center · Staten Island, NY |
| 25 | Sat Feb 7 | vsSt Francis PA | W86-84 | 12-13 | .480 | - | | Ted Grant Court · Syracuse, NY |
| 26 | Thu Feb 12 | vsMercyhurst | W58-57 | 13-13 | .500 | - | | Ted Grant Court · Syracuse, NY |
| 27 | Sat Feb 14 | vsChicago St | W81-63 | 14-13 | .519 | - | | Ted Grant Court · Syracuse, NY |
| 28 | Thu Feb 19 | atC Connecticut | L77-78 | 14-14 | .500 | - | | William H. Detrick Gymnasium · New Britain, CT |
| 29 | Sat Feb 21 | atStonehill | L68-77 | 14-15 | .483 | - | ESPN+ | placeholder · sf, ca |
| 30 | Thu Feb 26 | vsFairleigh | W76-59 | 15-15 | .500 | - | | Ted Grant Court · Syracuse, NY |
| 31 | Sat Feb 28 | atNew Haven | L59-66 | 15-16 | .484 | - | | Jeffery P. Hazell Athletics Center |
