| 1 | Mon Nov 4 | at Villanova | L63-75 | 0-1 | .000 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 2 | Sat Nov 9 | at La Salle | L60-81 | 0-2 | .000 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 3 | Tue Nov 12 | vs Penn | W65-63 | 1-2 | .333 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 4 | Sat Nov 16 | at Cornell | L71-81 | 1-3 | .250 | - | ESPN+ | Newman Arena · Ithaca, NY |
| 5 | Wed Nov 20 | at Rhode Island | L72-86 | 1-4 | .200 | - | ESPN+ | Ryan Center · Kingston, RI |
| 6 | Sun Nov 24 | vs TBD | W91-45 | 2-4 | .333 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 7 | Fri Nov 29 | vs Long Island | W75-56 | 3-4 | .429 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 8 | Sat Nov 30 | vs Niagara | W59-47 | 4-4 | .500 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 9 | Sun Dec 1 | vs Binghamton | L81-82 (OT) | 4-5 | .444 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 10 | Sat Dec 7 | at Mercyhurst | W77-73 | 5-5 | .500 | - | | Mercyhurst Athletic Center · Erie, PA |
| 11 | Wed Dec 18 | at G Washington | L62-82 | 5-6 | .455 | - | ESPN+ | Charles E. Smith Center · Washington, D.C. |
| 12 | Sat Dec 21 | at Portland | L64-74 | 5-7 | .417 | - | ESPN+ | Chiles Center · Portland, OR |
| 13 | Sun Dec 29 | vs Stonehill | L65-70 | 5-8 | .385 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 14 | Thu Jan 2 | vs Boston Univ | W60-46 | 6-8 | .429 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 15 | Sun Jan 5 | at Navy | L70-71 | 6-9 | .400 | - | ESPN+ | Alumni Hall (Navy) · Annapolis, MD |
| 16 | Wed Jan 8 | at Bucknell | L62-65 (OT) | 6-10 | .375 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 17 | Sat Jan 11 | vs Holy Cross | W82-65 | 7-10 | .412 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 18 | Wed Jan 15 | at Army | L68-70 | 7-11 | .389 | - | ESPN+ | Christl Arena · West Point, NY |
| 19 | Sat Jan 18 | vs Colgate | L67-90 | 7-12 | .368 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 20 | Wed Jan 22 | at Loyola MD | W80-59 | 8-12 | .400 | - | ESPN+ | Reitz Arena · Baltimore, MD |
| 21 | Sat Jan 25 | at Lehigh | L47-86 | 8-13 | .381 | - | ESPN+ | Stabler Arena · Bethlehem, PA |
| 22 | Wed Jan 29 | vs American | L68-75 | 8-14 | .364 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 23 | Sat Feb 1 | atColgate | W76-61 | 9-14 | .391 | - | ESPN+ | Cotterell Court · Hamilton, NY |
| 24 | Wed Feb 5 | vsLoyola MD | L58-71 | 9-15 | .375 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 25 | Sat Feb 8 | vsNavy | W61-51 | 10-15 | .400 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 26 | Mon Feb 10 | atAmerican | L58-60 | 10-16 | .385 | - | CBS | Bender Arena · Washington, D.C. |
| 27 | Sat Feb 15 | vsBucknell | L69-75 | 10-17 | .370 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 28 | Wed Feb 19 | atHoly Cross | L69-74 (OT) | 10-18 | .357 | - | ESPN+ | Hart Center · Worcester, MA |
