| 1 | Mon Nov 4 | at Delaware | W85-73 | 1-0 | 1.000 | - | FloSports | Bob Carpenter Center · Newark, DE |
| 2 | Thu Nov 7 | at So Indiana | W75-69 (OT) | 2-0 | 1.000 | - | ESPN+ | Screaming Eagles Arena · Evansville, IN |
| 3 | Sat Nov 9 | at #23Kentucky | L72-100 | 2-1 | .667 | - | ESPN+ | Rupp Arena · Lexington, KY |
| 4 | Wed Nov 13 | vs Mount St Mary | L89-93 (2OT) | 2-2 | .500 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 5 | Sat Nov 16 | vs Richmond | W80-76 (2OT) | 3-2 | .600 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 6 | Thu Nov 21 | vs NJIT | W81-64 | 4-2 | .667 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 7 | Sat Nov 23 | vs Rider | L53-57 | 4-3 | .571 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 8 | Wed Nov 27 | at Maryland | L67-91 | 4-4 | .500 | - | BTN | XFINITY Center · College Park, MD |
| 9 | Sat Nov 30 | vs Siena | L58-71 | 4-5 | .444 | - | | Sojka Pavilion · Lewisburg, PA |
| 10 | Wed Dec 4 | vs St Bonaventure | L47-64 | 4-6 | .400 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 11 | Sun Dec 8 | at Radford | L70-74 (OT) | 4-7 | .364 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 12 | Sat Dec 21 | at #13Gonzaga | L65-86 | 4-8 | .333 | - | ESPN+ | McCarthey Athletic Center · Spokane, WA |
| 13 | Sat Dec 28 | at Syracuse | L63-75 | 4-9 | .308 | - | The CW Network | JMA Wireless Dome · Syracuse, NY |
| 14 | Thu Jan 2 | at Lehigh | L64-66 (OT) | 4-10 | .286 | - | ESPN+ | Stabler Arena · Bethlehem, PA |
| 15 | Sun Jan 5 | vs Colgate | W66-60 | 5-10 | .333 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 16 | Wed Jan 8 | vs Lafayette | W65-62 (OT) | 6-10 | .375 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 17 | Sat Jan 11 | at American | L58-68 | 6-11 | .353 | - | ESPN+ | Bender Arena · Washington, D.C. |
| 18 | Wed Jan 15 | vs Holy Cross | W86-82 | 7-11 | .389 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 19 | Sat Jan 18 | vs Navy | W73-69 | 8-11 | .421 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 20 | Mon Jan 20 | atColgate | L80-87 | 8-12 | .400 | - | CBS | Cotterell Court · Hamilton, NY |
| 21 | Sat Jan 25 | at Boston Univ | L82-85 (OT) | 8-13 | .381 | - | ESPN+ | Case Gym · Boston, MA |
| 22 | Wed Jan 29 | vs Loyola MD | W79-67 | 9-13 | .409 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 23 | Sat Feb 1 | atNavy | W85-75 | 10-13 | .435 | - | ESPN+ | Alumni Hall (Navy) · Annapolis, MD |
| 24 | Wed Feb 5 | vsAmerican | W71-49 | 11-13 | .458 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 25 | Sat Feb 8 | at Army | L110-116 (2OT) | 11-14 | .440 | - | ESPN+ | Christl Arena · West Point, NY |
| 26 | Wed Feb 12 | vsBoston Univ | W76-60 | 12-14 | .462 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 27 | Sat Feb 15 | atLafayette | W75-69 | 13-14 | .481 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 28 | Mon Feb 17 | vsLehigh | W67-50 | 14-14 | .500 | - | CBS | Sojka Pavilion · Lewisburg, PA |
| 29 | Sun Feb 23 | vsArmy | W84-53 | 15-14 | .517 | - | CBS | Sojka Pavilion · Lewisburg, PA |
| 30 | Wed Feb 26 | atLoyola MD | W70-67 | 16-14 | .533 | - | ESPN+ | Reitz Arena · Baltimore, MD |
| 31 | Sat Mar 1 | atHoly Cross | W94-81 | 17-14 | .548 | - | ESPN+ | Hart Center · Worcester, MA |
| 32 | Thu Mar 6 | vsLoyola MD | W76-72 (OT) | 18-14 | .563 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 33 | Sun Mar 9 | vsNavy | L77-83 | 18-15 | .545 | - | | Sojka Pavilion · Lewisburg, PA |
