| 1 | Wed Nov 5 | vs Coppin St | W87-59 | 1-0 | 1.000 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 2 | Sat Nov 8 | vsMonmouth | W73-60 | 2-0 | 1.000 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 3 | Tue Nov 11 | atTemple | L63-90 | 2-1 | .667 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 4 | Sat Nov 15 | vsPenn State | L69-83 | 2-2 | .500 | - | Peacock | Tom Gola Arena · Philadelphia, PA |
| 5 | Wed Nov 19 | vsVillanova | L55-70 | 2-3 | .400 | - | CBSSN | Tom Gola Arena · Philadelphia, PA |
| 6 | Sat Nov 22 | vsTBD | W75-46 | 3-3 | .500 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 7 | Fri Nov 28 | vsHofstra | L58-63 | 3-4 | .429 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 8 | Sat Nov 29 | atPenn | L71-73 | 3-5 | .375 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 9 | Sun Nov 30 | vsMerrimack | L60-66 | 3-6 | .333 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 10 | Sat Dec 6 | vsDrexel | W69-64 | 4-6 | .400 | - | | Tom Gola Arena · Philadelphia, PA |
| 11 | Sat Dec 13 | atLong Island | L60-70 | 4-7 | .364 | - | | Steinberg Wellness Center · Brooklyn, NY |
| 12 | Fri Dec 19 | atHigh Point | L72-84 | 4-8 | .333 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
| 13 | Sun Dec 21 | at2Michigan | L50-102 | 4-9 | .308 | - | Peacock | Crisler Center · Ann Arbor, MI |
| 14 | Wed Dec 31 | vsGeorge Mason | L75-80 | 4-10 | .286 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 15 | Sat Jan 3 | atG Washington | L55-77 | 4-11 | .267 | - | USA Net | Charles E. Smith Center · Washington, D.C. |
| 16 | Wed Jan 7 | atRhode Island | W79-72 | 5-11 | .313 | - | ESPN+ | Ryan Center · Kingston, RI |
| 17 | Sat Jan 10 | vsSaint Louis | L72-84 | 5-12 | .294 | - | USA Net | Tom Gola Arena · Philadelphia, PA |
| 18 | Wed Jan 14 | atRichmond | L53-74 | 5-13 | .278 | - | ESPN+ | Robins Center · Richmond, VA |
| 19 | Sat Jan 17 | vsSt Bonaventure | W78-74 | 6-13 | .316 | - | USA Net | Tom Gola Arena · Philadelphia, PA |
| 20 | Wed Jan 21 | vsDayton | W67-64 | 7-13 | .350 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 21 | Wed Jan 28 | atFordham | L58-64 | 7-14 | .333 | - | ESPN+ | Rose Hill Gymnasium · Bronx, NY |
| 22 | Sat Jan 31 | vsSaint Joseph's | L58-67 | 7-15 | .318 | - | USA Net | Tom Gola Arena · Philadelphia, PA |
| 23 | Tue Feb 3 | atLoyola Chicago | L61-71 | 7-16 | .304 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 24 | Sat Feb 7 | at19Saint Louis | L58-82 | 7-17 | .292 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 25 | Wed Feb 11 | vsVCU | L68-77 | 7-18 | .280 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 26 | Wed Feb 18 | atDuquesne | L61-62 | 7-19 | .269 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 27 | Sat Feb 21 | vsRhode Island | W59-46 | 8-19 | .296 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 28 | Tue Feb 24 | vsG Washington | L77-104 | 8-20 | .286 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 29 | Sun Mar 1 | atDavidson | L64-71 | 8-21 | .276 | - | USA Net | John M. Belk Arena · Davidson, NC |
