| 1 | Mon Nov 4 | vs American | W65-52 | 1-0 | 1.000 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 2 | Sat Nov 9 | vs Lafayette | W81-60 | 2-0 | 1.000 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 3 | Tue Nov 12 | vs Cornell | W93-77 | 3-0 | 1.000 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 4 | Sat Nov 16 | at Drexel | W71-68 | 4-0 | 1.000 | - | FloSports | Daskalakis Athletic Center · Philadelphia, PA |
| 5 | Thu Nov 21 | at UC San Diego | L67-72 | 4-1 | .800 | - | | University Credit Union Center · Davis, CA |
| 6 | Fri Nov 22 | at UIC | L83-96 | 4-2 | .667 | - | | Credit Union 1 Arena · Chicago, IL |
| 7 | Sat Nov 23 | at Stetson | W92-77 | 5-2 | .714 | - | | Edmunds Center · Deland, FL |
| 8 | Sat Nov 30 | vs Temple | W83-75 | 6-2 | .750 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 9 | Tue Dec 3 | at Northeastern | L68-82 | 6-3 | .667 | - | | Matthews Arena · Boston, MA |
| 10 | Sat Dec 7 | vs Saint Joseph's | L68-82 | 6-4 | .600 | - | | Tom Gola Arena · Philadelphia, PA |
| 11 | Sat Dec 14 | at UNC | L67-93 | 6-5 | .545 | - | The CW Network | Dean E. Smith Center · Chapel Hill, NC |
| 12 | Wed Dec 18 | vs Fairleigh | W77-72 | 7-5 | .583 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 13 | Sat Dec 21 | vs TBD | W108-48 | 8-5 | .615 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 14 | Tue Dec 31 | at Dayton | L70-84 | 8-6 | .571 | - | ESPN+ | UD Arena · Dayton, OH |
| 15 | Wed Jan 8 | vs Loyola Chicago | L68-79 | 8-7 | .533 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 16 | Sat Jan 11 | at St Bonaventure | W83-82 (OT) | 9-7 | .563 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 17 | Wed Jan 15 | vs Davidson | W79-76 | 10-7 | .588 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 18 | Sun Jan 19 | at UMass | L60-82 | 10-8 | .556 | - | USA Net | William D. Mullins Memorial Center · Amherst, MA |
| 19 | Wed Jan 22 | at Saint Louis | L52-64 | 10-9 | .526 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 20 | Sat Jan 25 | vs Rhode Island | W70-64 | 11-9 | .550 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 21 | Wed Jan 29 | vs Fordham | L72-88 | 11-10 | .524 | - | | Tom Gola Arena · Philadelphia, PA |
| 22 | Sat Feb 1 | vs G Washington | W73-67 | 12-10 | .545 | - | | Tom Gola Arena · Philadelphia, PA |
| 23 | Tue Feb 4 | at VCU | L66-96 | 12-11 | .522 | - | CBS | Stuart C. Siegel Center · Richmond, VA |
| 24 | Sun Feb 9 | vsUMass | L55-78 | 12-12 | .500 | - | | Tom Gola Arena · Philadelphia, PA |
| 25 | Wed Feb 12 | atSaint Joseph's | L63-75 | 12-13 | .480 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 26 | Sat Feb 15 | atRhode Island | L71-86 | 12-14 | .462 | - | ESPN+ | Ryan Center · Kingston, RI |
| 27 | Wed Feb 19 | vs Richmond | L58-63 | 12-15 | .444 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
Duquesne
George Mason