| 1 | Tue Nov 7 | vs Drexel | W67-61 | 1-0 | 1.000 | - | | Tom Gola Arena · Philadelphia, PA |
| 2 | Sat Nov 11 | vsNortheastern | W79-74 | 2-0 | 1.000 | - | | Tom Gola Arena · Philadelphia, PA |
| 3 | Tue Nov 14 | vsBucknell | W69-57 | 3-0 | 1.000 | - | | Tom Gola Arena · Philadelphia, PA |
| 4 | Sat Nov 18 | vsSo Indiana | W79-78 | 4-0 | 1.000 | - | | Tom Gola Arena · Philadelphia, PA |
| 5 | Tue Nov 21 | at9Duke | L66-95 | 4-1 | .800 | - | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 6 | Sun Nov 26 | vsCoppin St | W81-62 | 5-1 | .833 | - | | Tom Gola Arena · Philadelphia, PA |
| 7 | Wed Nov 29 | atTemple | L99-106 (3OT) | 5-2 | .714 | - | | Liacouras Center · Philadelphia, PA |
| 8 | Sat Dec 2 | vsPenn | W93-92 (OT) | 6-2 | .750 | - | | Xfinity Mobile Arena · Philadelphia, PA |
| 9 | Wed Dec 6 | vsLoyola MD | W62-61 | 7-2 | .778 | - | | Tom Gola Arena · Philadelphia, PA |
| 10 | Sat Dec 9 | atLafayette | W67-51 | 8-2 | .800 | - | | Kirby Sports Center · Easton, PA |
| 11 | Sat Dec 16 | at24Miami | L77-84 | 8-3 | .727 | - | The CW Network | Watsco Center · Coral Gables, FL |
| 12 | Thu Dec 21 | vsTBD | W107-41 | 9-3 | .750 | - | | Tom Gola Arena · Philadelphia, PA |
| 13 | Sat Dec 30 | vsHoward | L66-71 | 9-4 | .692 | - | | Tom Gola Arena · Philadelphia, PA |
| 14 | Wed Jan 3 | vsGeorge Mason | L62-77 | 9-5 | .643 | - | | Tom Gola Arena · Philadelphia, PA |
| 15 | Sat Jan 6 | atFordham | W81-76 | 10-5 | .667 | - | USA Net | Rose Hill Gymnasium · Bronx, NY |
| 16 | Wed Jan 10 | atUMass | L65-81 | 10-6 | .625 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 17 | Sat Jan 13 | vsVCU | L65-71 | 10-7 | .588 | - | USA Net | Tom Gola Arena · Philadelphia, PA |
| 18 | Mon Jan 15 | atSaint Joseph's | L62-82 | 10-8 | .556 | - | CBSSN | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 19 | Tue Jan 23 | vs16Dayton | L54-66 | 10-9 | .526 | - | | Tom Gola Arena · Philadelphia, PA |
| 20 | Sat Jan 27 | atG Washington | W80-70 | 11-9 | .550 | - | | Charles E. Smith Center · Washington, D.C. |
| 21 | Wed Jan 31 | atRhode Island | L69-71 | 11-10 | .524 | - | | Ryan Center · Kingston, RI |
| 22 | Sat Feb 3 | vsSaint Joseph's | L82-88 | 11-11 | .500 | - | ESPNU | Tom Gola Arena · Philadelphia, PA |
| 23 | Wed Feb 7 | vsSaint Louis | L84-102 | 11-12 | .478 | - | | Tom Gola Arena · Philadelphia, PA |
| 24 | Sat Feb 10 | atRichmond | L65-82 | 11-13 | .458 | - | | Robins Center · Richmond, VA |
| 25 | Tue Feb 13 | atDavidson | L56-71 | 11-14 | .440 | - | | John M. Belk Arena · Davidson, NC |
| 26 | Sat Feb 17 | vsUMass | W82-81 | 12-14 | .462 | - | | Tom Gola Arena · Philadelphia, PA |
| 27 | Wed Feb 21 | vsSt Bonaventure | W72-59 | 13-14 | .481 | - | | Tom Gola Arena · Philadelphia, PA |
| 28 | Sun Feb 25 | vsRhode Island | W84-61 | 14-14 | .500 | - | USA Net | Tom Gola Arena · Philadelphia, PA |
| 29 | Wed Feb 28 | atDuquesne | L63-75 | 14-15 | .483 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 30 | Sat Mar 2 | vsG Washington | W72-66 | 15-15 | .500 | - | | Tom Gola Arena · Philadelphia, PA |
| 31 | Sat Mar 9 | atLoyola Chicago | L54-64 | 15-16 | .484 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 32 | Tue Mar 12 | vsG Washington | W61-60 | 16-16 | .500 | - | | Tom Gola Arena · Philadelphia, PA |
| 33 | Wed Mar 13 | atSt Bonaventure | L73-75 | 16-17 | .485 | - | USA Net | Reilly Center · Saint Bonaventure, NY |
