| 1 | Mon Nov 4 | vs St Francis PA | W87-57 | 1-0 | 1.000 | - | ESPN+ | UD Arena · Dayton, OH |
| 2 | Sat Nov 9 | vs Northwestern | W71-66 | 2-0 | 1.000 | - | ESPN+ | UD Arena · Dayton, OH |
| 3 | Wed Nov 13 | vs Ball State | W77-69 | 3-0 | 1.000 | - | ESPN+ | UD Arena · Dayton, OH |
| 4 | Sat Nov 16 | vs TBD | W76-55 | 4-0 | 1.000 | - | ESPN+ | UD Arena · Dayton, OH |
| 5 | Wed Nov 20 | vs New Mexico St | W74-53 | 5-0 | 1.000 | - | ESPN+ | UD Arena · Dayton, OH |
| 6 | Mon Nov 25 | at #12UNC | L90-92 | 5-1 | .833 | - | ESPN2 | Dean E. Smith Center · Chapel Hill, NC |
| 7 | Tue Nov 26 | vs #5Iowa State | L84-89 | 5-2 | .714 | - | ESPNU | UD Arena · Dayton, OH |
| 8 | Wed Nov 27 | vs #2UConn | W85-67 | 6-2 | .750 | - | ESPN2 | UD Arena · Dayton, OH |
| 9 | Tue Dec 3 | vs W Michigan | W77-69 | 7-2 | .778 | - | ESPN+ | UD Arena · Dayton, OH |
| 10 | Sat Dec 7 | vs Lehigh | W86-62 | 8-2 | .800 | - | ESPN+ | UD Arena · Dayton, OH |
| 11 | Sat Dec 14 | vs #6Marquette | W71-63 | 9-2 | .818 | - | CBS | UD Arena · Dayton, OH |
| 12 | Tue Dec 17 | vs UNLV | W66-65 | 10-2 | .833 | #22 | CBS | UD Arena · Dayton, OH |
| 13 | Fri Dec 20 | vs #19Cincinnati | L59-66 | 10-3 | .769 | #22 | ESPNU | UD Arena · Dayton, OH |
| 14 | Tue Dec 31 | vs La Salle | W84-70 | 11-3 | .786 | - | ESPN+ | UD Arena · Dayton, OH |
| 15 | Sat Jan 4 | at G Washington | L62-82 | 11-4 | .733 | - | USA Net | Charles E. Smith Center · Washington, D.C. |
| 16 | Wed Jan 8 | at UMass | L72-76 | 11-5 | .688 | - | Peacock | William D. Mullins Memorial Center · Amherst, MA |
| 17 | Wed Jan 15 | vs George Mason | L59-67 | 11-6 | .647 | - | CBS | UD Arena · Dayton, OH |
| 18 | Sat Jan 18 | vs Loyola Chicago | W83-81 (OT) | 12-6 | .667 | - | CBS | UD Arena · Dayton, OH |
| 19 | Tue Jan 21 | at Duquesne | W82-62 | 13-6 | .684 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 20 | Fri Jan 24 | vs Saint Joseph's | W77-72 | 14-6 | .700 | - | ESPN2 | UD Arena · Dayton, OH |
| 21 | Tue Jan 28 | at St Bonaventure | L53-75 | 14-7 | .667 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 22 | Fri Jan 31 | at Saint Louis | W71-63 | 15-7 | .682 | - | ESPN2 | Chaifetz Arena · St. Louis, MO |
| 23 | Tue Feb 4 | vs Davidson | W69-63 | 16-7 | .696 | - | ESPN+ | UD Arena · Dayton, OH |
| 24 | Fri Feb 7 | vs VCU | L68-73 | 16-8 | .667 | - | ESPN2 | UD Arena · Dayton, OH |
| 25 | Wed Feb 12 | at Fordham | W93-76 | 17-8 | .680 | - | ESPN+ | Rose Hill Gymnasium · Bronx, NY |
| 26 | Sat Feb 15 | vsDuquesne | W77-76 | 18-8 | .692 | - | USA Net | UD Arena · Dayton, OH |
| 27 | Fri Feb 21 | atLoyola Chicago | L72-76 | 18-9 | .667 | - | ESPN2 | Joseph J. Gentile Arena · Chicago, IL |
| 28 | Wed Feb 26 | at Rhode Island | W85-77 | 19-9 | .679 | - | CBS | Ryan Center · Kingston, RI |
| 29 | Sat Mar 1 | vs Richmond | W74-64 (2OT) | 20-9 | .690 | - | CBS | UD Arena · Dayton, OH |
| 30 | Tue Mar 4 | vsSaint Louis | W75-67 | 21-9 | .700 | - | ESPN+ | UD Arena · Dayton, OH |
| 31 | Fri Mar 7 | atVCU | W79-76 | 22-9 | .710 | - | ESPN2 | Stuart C. Siegel Center · Richmond, VA |
| 32 | Fri Mar 14 | vsSaint Joseph's | L68-73 (OT) | 22-10 | .688 | - | Peacock | UD Arena · Dayton, OH |
| 33 | Wed Mar 19 | vs FAU | W86-79 | 23-10 | .697 | - | ESPN2 | UD Arena · Dayton, OH |
| 34 | Sat Mar 22 | at Chattanooga | L72-87 | 23-11 | .676 | - | ESPN2 | McKenzie Arena · Chattanooga, TN |
