| 1 | Mon Nov 3 | vs Canisius | W88-48 | 1-0 | 1.000 | - | ESPN+ | UD Arena · Dayton, OH |
| 2 | Sat Nov 8 | vsUMBC | W77-71 | 2-0 | 1.000 | - | ESPN+ | UD Arena · Dayton, OH |
| 3 | Tue Nov 11 | atCincinnati | L62-74 | 2-1 | .667 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 4 | Sat Nov 15 | vsBethune | W91-82 | 3-1 | .750 | - | ESPN+ | UD Arena · Dayton, OH |
| 5 | Wed Nov 19 | atMarquette | W77-71 (OT) | 4-1 | .800 | - | truTV | Fiserv Forum · Milwaukee, WI |
| 6 | Sat Nov 22 | vsNC Central | W74-55 | 5-1 | .833 | - | ESPN+ | UD Arena · Dayton, OH |
| 7 | Thu Nov 27 | vsGeorgetown | W84-79 (OT) | 6-1 | .857 | - | ESPN2 | UD Arena · Dayton, OH |
| 8 | Fri Nov 28 | vs9BYU | L79-83 | 6-2 | .750 | - | ESPN | UD Arena · Dayton, OH |
| 9 | Tue Dec 2 | vsETSU | W88-71 | 7-2 | .778 | - | ESPN+ | UD Arena · Dayton, OH |
| 10 | Sat Dec 6 | atVirginia | L73-86 | 7-3 | .700 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 11 | Sat Dec 13 | vsNorth Florida | W84-61 | 8-3 | .727 | - | ESPN+ | UD Arena · Dayton, OH |
| 12 | Tue Dec 16 | vsFlorida St | W97-69 | 9-3 | .750 | - | CBSSN | UD Arena · Dayton, OH |
| 13 | Sat Dec 20 | vsLiberty | L61-64 | 9-4 | .692 | - | USA Net | UD Arena · Dayton, OH |
| 14 | Wed Dec 31 | vsFordham | W63-56 | 10-4 | .714 | - | ESPN+ | UD Arena · Dayton, OH |
| 15 | Sat Jan 3 | atLoyola Chicago | W70-68 | 11-4 | .733 | - | CBSSN | Joseph J. Gentile Arena · Chicago, IL |
| 16 | Tue Jan 6 | vsG Washington | W79-72 | 12-4 | .750 | - | CBSSN | UD Arena · Dayton, OH |
| 17 | Tue Jan 13 | atDuquesne | W71-65 | 13-4 | .765 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 18 | Fri Jan 16 | vsLoyola Chicago | W78-51 | 14-4 | .778 | - | ESPN2 | UD Arena · Dayton, OH |
| 19 | Wed Jan 21 | atLa Salle | L64-67 | 14-5 | .737 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 20 | Sat Jan 24 | atSaint Joseph's | L74-81 | 14-6 | .700 | - | CBSSN | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 21 | Tue Jan 27 | vsRhode Island | L76-81 (OT) | 14-7 | .667 | - | ESPN+ | UD Arena · Dayton, OH |
| 22 | Fri Jan 30 | at21Saint Louis | L71-102 | 14-8 | .636 | - | CBSSN | Chaifetz Arena · St. Louis, MO |
| 23 | Tue Feb 3 | vsSt Bonaventure | W72-70 | 15-8 | .652 | - | CBSSN | UD Arena · Dayton, OH |
| 24 | Fri Feb 6 | atVCU | L73-99 | 15-9 | .625 | - | ESPN2 | Stuart C. Siegel Center · Richmond, VA |
| 25 | Sun Feb 15 | vsDavidson | W70-59 | 16-9 | .640 | - | ESPN2 | UD Arena · Dayton, OH |
| 26 | Wed Feb 18 | atGeorge Mason | W82-67 | 17-9 | .654 | - | CBSSN | EagleBank Arena · Fairfax, VA |
| 27 | Sat Feb 21 | vsDuquesne | W78-66 | 18-9 | .667 | - | ESPN+ | UD Arena · Dayton, OH |
| 28 | Tue Feb 24 | vs23Saint Louis | W77-62 | 19-9 | .679 | - | ESPN+ | UD Arena · Dayton, OH |
| 29 | Fri Feb 27 | atG Washington | W68-66 | 20-9 | .690 | - | ESPN2 | Charles E. Smith Center · Washington, D.C. |
