| 1 | Tue Nov 9 | vs UIC | W64-54 | 1-0 | 1.000 | - | | UD Arena · Dayton, OH |
| 2 | Sat Nov 13 | vsUMass Lowell | L58-59 | 1-1 | .500 | - | | UD Arena · Dayton, OH |
| 3 | Wed Nov 17 | vsLipscomb | L59-78 | 1-2 | .333 | - | | UD Arena · Dayton, OH |
| 4 | Sat Nov 20 | vsAustin Peay | L81-87 | 1-3 | .250 | - | | UD Arena · Dayton, OH |
| 5 | Thu Nov 25 | atMiami | W76-60 | 2-3 | .400 | - | ESPN2 | Watsco Center · Coral Gables, FL |
| 6 | Fri Nov 26 | atKansas | W74-73 | 3-3 | .500 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 7 | Sun Nov 28 | atBelmont | W63-61 | 4-3 | .571 | - | ESPN2 | Curb Event Center Arena · Nashville, TN |
| 8 | Wed Dec 1 | vsAlabama St | W93-54 | 5-3 | .625 | - | | UD Arena · Dayton, OH |
| 9 | Sat Dec 4 | vsN Illinois | W79-41 | 6-3 | .667 | - | | UD Arena · Dayton, OH |
| 10 | Wed Dec 8 | atSMU | L69-77 | 6-4 | .600 | - | | Moody Coliseum · Dallas, TX |
| 11 | Sun Dec 12 | vsVirginia Tech | W62-57 | 7-4 | .636 | - | ESPN2 | UD Arena · Dayton, OH |
| 12 | Sat Dec 18 | atOle Miss | L68-76 | 7-5 | .583 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 13 | Tue Dec 21 | vsSouthern | W69-60 | 8-5 | .615 | - | | UD Arena · Dayton, OH |
| 14 | Thu Dec 30 | atRhode Island | PPD | 24-11 | .686 | - | | Ryan Center · Kingston, RI |
| 15 | Sun Jan 2 | vsSt Bonaventure | PPD | 24-11 | .686 | - | | UD Arena · Dayton, OH |
| 16 | Wed Jan 5 | vsVCU | L52-53 | 8-6 | .571 | - | CBS | UD Arena · Dayton, OH |
| 17 | Sat Jan 8 | atG Washington | W83-58 | 9-6 | .600 | - | | Charles E. Smith Center · Washington, D.C. |
| 18 | Tue Jan 11 | vsSaint Louis | W68-63 | 10-6 | .625 | - | CBS | UD Arena · Dayton, OH |
| 19 | Sat Jan 15 | atDuquesne | W72-52 | 11-6 | .647 | - | USA Net | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 20 | Tue Jan 18 | vsSt Bonaventure | W68-50 | 12-6 | .667 | - | | UD Arena · Dayton, OH |
| 21 | Sat Jan 22 | atGeorge Mason | L49-50 | 12-7 | .632 | - | | EagleBank Arena · Fairfax, VA |
| 22 | Tue Jan 25 | vsFordham | W68-61 | 13-7 | .650 | - | | UD Arena · Dayton, OH |
| 23 | Fri Jan 28 | vsRhode Island | W53-51 | 14-7 | .667 | - | ESPN2 | UD Arena · Dayton, OH |
| 24 | Wed Feb 2 | atVCU | W82-52 | 15-7 | .682 | - | CBS | Stuart C. Siegel Center · Richmond, VA |
| 25 | Sat Feb 5 | atSaint Louis | L61-72 | 15-8 | .652 | - | ESPNU | Chaifetz Arena · St. Louis, MO |
| 26 | Wed Feb 9 | vsDuquesne | W75-54 | 16-8 | .667 | - | | UD Arena · Dayton, OH |
| 27 | Sat Feb 12 | vsG Washington | W80-54 | 17-8 | .680 | - | | UD Arena · Dayton, OH |
| 28 | Mon Feb 14 | atRhode Island | W63-57 | 18-8 | .692 | - | CBS | Ryan Center · Kingston, RI |
| 29 | Sat Feb 19 | atSaint Joseph's | W74-62 | 19-8 | .704 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 30 | Wed Feb 23 | vsUMass | W82-61 | 20-8 | .714 | - | | UD Arena · Dayton, OH |
| 31 | Sat Feb 26 | atLa Salle | L60-62 | 20-9 | .690 | - | | Tom Gola Arena · Philadelphia, PA |
| 32 | Tue Mar 1 | atRichmond | W55-53 | 21-9 | .700 | - | CBS | Robins Center · Richmond, VA |
| 33 | Sat Mar 5 | vsDavidson | W82-76 | 22-9 | .710 | - | USA Net | UD Arena · Dayton, OH |
| 34 | Fri Mar 11 | vsUMass | W75-72 | 23-9 | .719 | - | USA Net | UD Arena · Dayton, OH |
| 35 | Sat Mar 12 | vsRichmond | L64-68 | 23-10 | .697 | - | CBS | UD Arena · Dayton, OH |
| 36 | Wed Mar 16 | atToledo | W74-55 | 24-10 | .706 | - | | Savage Arena · Toledo, OH |
| 37 | Sun Mar 20 | atVanderbilt | L68-70 (OT) | 24-11 | .686 | - | ESPN2 | Memorial Gymnasium (TN) · Nashville, TN |
