| 1 | Mon Nov 4 | at Santa Clara | L78-85 | 0-1 | .000 | - | | Leavey Center · Santa Clara, CA |
| 2 | Sun Nov 10 | vs TBD | W95-44 | 1-1 | .500 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 3 | Sat Nov 16 | vs LMU | W77-71 | 2-1 | .667 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 4 | Fri Nov 22 | vs Wichita St | L63-88 | 2-2 | .500 | - | Peacock | Chaifetz Arena · St. Louis, MO |
| 5 | Mon Nov 25 | vs Quinnipiac | W81-67 | 3-2 | .600 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 6 | Wed Nov 27 | vs UMass Lowell | W93-90 | 4-2 | .667 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 7 | Mon Dec 2 | vs Jackson St | W74-66 | 5-2 | .714 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 8 | Thu Dec 5 | at San Francisco | L61-78 | 5-3 | .625 | - | ESPN+ | War Memorial at the Sobrato Center · San Francisco, CA |
| 9 | Sun Dec 8 | vs Chicago St | W85-62 | 6-3 | .667 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 10 | Sun Dec 15 | at Illinois St | L77-81 | 6-4 | .600 | - | ESPN+ | Redbird Arena · Normal, IL |
| 11 | Wed Dec 18 | vs Wofford | L71-74 | 6-5 | .545 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 12 | Sun Dec 22 | at Grand Canyon | L72-73 | 6-6 | .500 | - | ESPN+ | GCU Arena · Phoenix, AZ |
| 13 | Sat Dec 28 | vsTBD | W78-57 | 7-6 | .538 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 14 | Tue Dec 31 | at Fordham | W88-63 | 8-6 | .571 | - | ESPN+ | Rose Hill Gymnasium · Bronx, NY |
| 15 | Fri Jan 3 | vs Saint Joseph's | W73-57 | 9-6 | .600 | - | ESPN2 | Chaifetz Arena · St. Louis, MO |
| 16 | Wed Jan 8 | vs St Bonaventure | W73-68 | 10-6 | .625 | - | Peacock | Chaifetz Arena · St. Louis, MO |
| 17 | Tue Jan 14 | at VCU | L62-78 | 10-7 | .588 | - | ESPN+ | Stuart C. Siegel Center · Richmond, VA |
| 18 | Sat Jan 18 | at Richmond | W63-59 | 11-7 | .611 | - | USA Net | Robins Center · Richmond, VA |
| 19 | Wed Jan 22 | vs La Salle | W64-52 | 12-7 | .632 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 20 | Sat Jan 25 | at G Washington | L61-67 | 12-8 | .600 | - | ESPN+ | Charles E. Smith Center · Washington, D.C. |
| 21 | Tue Jan 28 | vsVCU | W78-69 | 13-8 | .619 | - | CBS | Chaifetz Arena · St. Louis, MO |
| 22 | Fri Jan 31 | vs Dayton | L63-71 | 13-9 | .591 | - | ESPN2 | Chaifetz Arena · St. Louis, MO |
| 23 | Tue Feb 4 | at UMass | W73-71 | 14-9 | .609 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 24 | Fri Feb 7 | atSaint Joseph's | L63-76 | 14-10 | .583 | - | ESPNU | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 25 | Tue Feb 11 | vs George Mason | L74-76 (OT) | 14-11 | .560 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 26 | Fri Feb 14 | at Loyola Chicago | L69-78 | 14-12 | .538 | - | ESPN2 | Joseph J. Gentile Arena · Chicago, IL |
Rhode Island
Davidson
Duquesne