| 1 | Tue Nov 9 | vs C Arkansas | W96-61 | 1-0 | 1.000 | - | | Chaifetz Arena · St. Louis, MO |
| 2 | Wed Nov 10 | vsTBD | W127-54 | 2-0 | 1.000 | - | | Chaifetz Arena · St. Louis, MO |
| 3 | Fri Nov 12 | vsE Illinois | W86-44 | 3-0 | 1.000 | - | | Chaifetz Arena · St. Louis, MO |
| 4 | Tue Nov 16 | at#11Memphis | L74-90 | 3-1 | .750 | - | | FedExForum · Memphis, TN |
| 5 | Sat Nov 20 | vsMercer | W75-58 | 4-1 | .800 | - | | Chaifetz Arena · St. Louis, MO |
| 6 | Tue Nov 23 | vsIllinois St | W82-76 | 5-1 | .833 | - | CBS | Chaifetz Arena · St. Louis, MO |
| 7 | Wed Nov 24 | vsSF Austin | W79-68 | 6-1 | .857 | - | | Chaifetz Arena · St. Louis, MO |
| 8 | Tue Nov 30 | atBoise St | W86-82 (OT) | 7-1 | .875 | - | | ExtraMile Arena · Boise, ID |
| 9 | Sat Dec 4 | vsUAB | L72-77 | 7-2 | .778 | - | | Chaifetz Arena · St. Louis, MO |
| 10 | Tue Dec 7 | vsBelmont | L59-64 | 7-3 | .700 | - | | Chaifetz Arena · St. Louis, MO |
| 11 | Sat Dec 11 | vsBoston College | W79-68 | 8-3 | .727 | - | | Chaifetz Arena · St. Louis, MO |
| 12 | Sat Dec 18 | vs#13Auburn | L70-74 | 8-4 | .667 | - | CBS | Chaifetz Arena · St. Louis, MO |
| 13 | Thu Dec 30 | atUMass | PPD | 23-12 | .657 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 14 | Sun Jan 2 | vsRichmond | W76-69 | 9-4 | .692 | - | CBS | Chaifetz Arena · St. Louis, MO |
| 15 | Wed Jan 5 | vsLa Salle | PPD | 23-12 | .657 | - | | Chaifetz Arena · St. Louis, MO |
| 16 | Sat Jan 8 | vsIona | W68-67 | 10-4 | .714 | - | | Chaifetz Arena · St. Louis, MO |
| 17 | Tue Jan 11 | atDayton | L63-68 | 10-5 | .667 | - | CBS | UD Arena · Dayton, OH |
| 18 | Sat Jan 15 | vsFordham | W63-45 | 11-5 | .688 | - | USA Net | Chaifetz Arena · St. Louis, MO |
| 19 | Thu Jan 20 | atUMass | L85-91 | 11-6 | .647 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 20 | Sun Jan 23 | vsUMass | W90-59 | 12-6 | .667 | - | | Chaifetz Arena · St. Louis, MO |
| 21 | Wed Jan 26 | vsG Washington | W80-67 | 13-6 | .684 | - | | Chaifetz Arena · St. Louis, MO |
| 22 | Sat Jan 29 | atDuquesne | W77-53 | 14-6 | .700 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 23 | Wed Feb 2 | atGeorge Mason | W92-90 (2OT) | 15-6 | .714 | - | | EagleBank Arena · Fairfax, VA |
| 24 | Sat Feb 5 | vsDayton | W72-61 | 16-6 | .727 | - | ESPNU | Chaifetz Arena · St. Louis, MO |
| 25 | Tue Feb 8 | atLa Salle | W75-57 | 17-6 | .739 | - | | Tom Gola Arena · Philadelphia, PA |
| 26 | Fri Feb 11 | vsSt Bonaventure | L61-68 | 17-7 | .708 | - | ESPN2 | Chaifetz Arena · St. Louis, MO |
| 27 | Mon Feb 14 | atSt Bonaventure | L79-83 | 17-8 | .680 | - | CBS | Reilly Center · Saint Bonaventure, NY |
| 28 | Wed Feb 16 | vsLa Salle | W90-64 | 18-8 | .692 | - | | Chaifetz Arena · St. Louis, MO |
| 29 | Sat Feb 19 | atDavidson | L58-79 | 18-9 | .667 | - | CBS | John M. Belk Arena · Davidson, NC |
| 30 | Tue Feb 22 | vsSaint Joseph's | W72-61 | 19-9 | .679 | - | | Chaifetz Arena · St. Louis, MO |
| 31 | Fri Feb 25 | atRichmond | L66-68 | 19-10 | .655 | - | ESPN2 | Robins Center · Richmond, VA |
| 32 | Wed Mar 2 | atRhode Island | W80-74 | 20-10 | .667 | - | | Ryan Center · Kingston, RI |
| 33 | Sat Mar 5 | vsVCU | W69-65 | 21-10 | .677 | - | ESPN2 | Chaifetz Arena · St. Louis, MO |
| 34 | Thu Mar 10 | vsLa Salle | W71-51 | 22-10 | .688 | - | USA Net | Capital One Arena · Washington, D.C. |
| 35 | Fri Mar 11 | atSt Bonaventure | W57-56 | 23-10 | .697 | - | USA Net | Capital One Arena · Washington, D.C. |
| 36 | Sat Mar 12 | atDavidson | L69-84 | 23-11 | .676 | - | CBS | Capital One Arena · Washington, D.C. |
| 37 | Wed Mar 16 | vsNorthern Iowa | L68-80 | 23-12 | .657 | - | | Chaifetz Arena · St. Louis, MO |
