| 1 | Wed Nov 25 | vs SIUE | W89-52 | 1-0 | 1.000 | - | | Chaifetz Arena · St. Louis, MO |
| 2 | Sat Nov 28 | vs LSU | W85-81 | 2-0 | 1.000 | - | | Chaifetz Arena · St. Louis, MO |
| 3 | Sat Dec 5 | vs AR-Pine Bluff | W107-54 | 3-0 | 1.000 | - | | Chaifetz Arena · St. Louis, MO |
| 4 | Tue Dec 8 | vs C Arkansas | W88-65 | 4-0 | 1.000 | - | | Chaifetz Arena · St. Louis, MO |
| 6 | Tue Dec 15 | vs Indiana St | W78-59 | 5-0 | 1.000 | - | | Chaifetz Arena · St. Louis, MO |
| 7 | Thu Dec 17 | vs NC State | W80-69 | 6-0 | 1.000 | - | | Chaifetz Arena · St. Louis, MO |
| 8 | Sun Dec 20 | at Minnesota | L82-90 | 6-1 | .857 | - | FS1 | Williams Arena · Minneapolis, MN |
| 9 | Wed Dec 23 | vs Kansas City | W62-46 | 7-1 | .875 | - | | Chaifetz Arena · St. Louis, MO |
| 11 | Sat Jan 2 | vs UMass | PPD | 14-7 | .667 | - | NBCSN | Chaifetz Arena · St. Louis, MO |
| 12 | Wed Jan 6 | at La Salle | PPD | 14-7 | .667 | #23 | | Tom Gola Arena · Philadelphia, PA |
| 15 | Tue Jan 26 | vs Dayton | L71-76 | 7-2 | .778 | #22 | CBS | Chaifetz Arena · St. Louis, MO |
| 17 | Wed Feb 3 | atLa Salle | L75-82 | 7-3 | .700 | - | | Tom Gola Arena · Philadelphia, PA |
| 18 | Sat Feb 6 | vs St Bonaventure | W70-59 | 8-3 | .727 | - | | Chaifetz Arena · St. Louis, MO |
| 19 | Wed Feb 10 | vs Rhode Island | W67-60 | 9-3 | .750 | - | CBS | Chaifetz Arena · St. Louis, MO |
| 20 | Sat Feb 13 | at Fordham | W68-40 | 10-3 | .769 | - | CBS | Rose Hill Gymnasium · Bronx, NY |
| 21 | Tue Feb 16 | vsLa Salle | W78-57 | 11-3 | .786 | - | CBS | Chaifetz Arena · St. Louis, MO |
| 22 | Fri Feb 19 | atDayton | L53-76 | 11-4 | .733 | - | ESPN2 | UD Arena · Dayton, OH |
| 23 | Tue Feb 23 | at VCU | L65-67 | 11-5 | .688 | - | CBS | Stuart C. Siegel Center · Richmond, VA |
| 24 | Fri Feb 26 | vs Richmond | W72-67 | 12-5 | .706 | - | ESPN2 | Chaifetz Arena · St. Louis, MO |
| 25 | Sun Feb 28 | vsUMass | PPD | 14-7 | .667 | - | | Chaifetz Arena · St. Louis, MO |
| 26 | Mon Mar 1 | vsUMass | W78-57 | 13-5 | .722 | - | | Chaifetz Arena · St. Louis, MO |
| 27 | Fri Mar 5 | vsUMass | W86-72 | 14-5 | .737 | - | NBCSN | Chaifetz Arena · St. Louis, MO |
| 28 | Sat Mar 6 | atSt Bonaventure | L53-71 | 14-6 | .700 | - | CBS | Reilly Center · Saint Bonaventure, NY |
| 29 | Sat Mar 20 | vs #4Mississippi St | L68-74 | 14-7 | .667 | #1 | ESPN | Chaifetz Arena · St. Louis, MO |
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