| 1 | Mon Nov 7 | vs Murray St | W91-68 | 1-0 | 1.000 | - | | Chaifetz Arena · St. Louis, MO |
| 2 | Sat Nov 12 | vsEvansville | W83-65 | 2-0 | 1.000 | - | | Chaifetz Arena · St. Louis, MO |
| 3 | Tue Nov 15 | vsMemphis | W90-84 | 3-0 | 1.000 | - | CBS | Chaifetz Arena · St. Louis, MO |
| 4 | Sat Nov 19 | atMaryland | L67-95 | 3-1 | .750 | - | ESPNEWS | XFINITY Center · College Park, MD |
| 5 | Sun Nov 20 | vsProvidence | W76-73 | 4-1 | .800 | - | ESPNU | Chaifetz Arena · St. Louis, MO |
| 6 | Wed Nov 23 | vsTBD | W96-53 | 5-1 | .833 | - | | Chaifetz Arena · St. Louis, MO |
| 7 | Sun Nov 27 | at#13Auburn | L60-65 | 5-2 | .714 | - | SEC Network | Neville Arena · Auburn, AL |
| 8 | Wed Nov 30 | vsTennessee St | W80-63 | 6-2 | .750 | - | | Chaifetz Arena · St. Louis, MO |
| 9 | Sat Dec 3 | vsS Illinois | W85-72 | 7-2 | .778 | - | | Chaifetz Arena · St. Louis, MO |
| 10 | Tue Dec 6 | atIona | L62-84 | 7-3 | .700 | - | | Hynes Athletics Center · New Rochelle, NY |
| 11 | Sat Dec 10 | vsBoise St | L52-57 | 7-4 | .636 | - | | Chaifetz Arena · St. Louis, MO |
| 12 | Sat Dec 17 | vsDrake | W83-75 | 8-4 | .667 | - | | Chaifetz Arena · St. Louis, MO |
| 13 | Wed Dec 21 | vsSIUE | L67-69 | 8-5 | .615 | - | | Chaifetz Arena · St. Louis, MO |
| 14 | Sat Dec 31 | atSaint Joseph's | W83-78 | 9-5 | .643 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 15 | Wed Jan 4 | atUMass | L81-90 | 9-6 | .600 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 16 | Sat Jan 7 | vsSt Bonaventure | W78-55 | 10-6 | .625 | - | | Chaifetz Arena · St. Louis, MO |
| 17 | Wed Jan 11 | vsGeorge Mason | W63-62 | 11-6 | .647 | - | | Chaifetz Arena · St. Louis, MO |
| 18 | Sat Jan 14 | atG Washington | W81-74 | 12-6 | .667 | - | | Charles E. Smith Center · Washington, D.C. |
| 19 | Wed Jan 18 | atLoyola Chicago | W76-59 | 13-6 | .684 | - | CBS | Joseph J. Gentile Arena · Chicago, IL |
| 20 | Sat Jan 21 | vsLa Salle | W84-71 | 14-6 | .700 | - | USA Net | Chaifetz Arena · St. Louis, MO |
| 21 | Fri Jan 27 | atDavidson | W74-70 | 15-6 | .714 | - | ESPN2 | John M. Belk Arena · Davidson, NC |
| 22 | Tue Jan 31 | atFordham | L65-75 | 15-7 | .682 | - | | Rose Hill Gymnasium · Bronx, NY |
| 23 | Fri Feb 3 | vsVCU | L65-73 | 15-8 | .652 | - | ESPN2 | Chaifetz Arena · St. Louis, MO |
| 24 | Tue Feb 7 | vsRhode Island | W76-71 | 16-8 | .667 | - | CBS | Chaifetz Arena · St. Louis, MO |
| 25 | Fri Feb 10 | atDayton | L56-70 | 16-9 | .640 | - | ESPN2 | UD Arena · Dayton, OH |
| 26 | Wed Feb 15 | vsDavidson | W78-65 | 17-9 | .654 | - | CBS | Chaifetz Arena · St. Louis, MO |
| 27 | Sat Feb 18 | vsDuquesne | W90-85 | 18-9 | .667 | - | | Chaifetz Arena · St. Louis, MO |
| 28 | Tue Feb 21 | atRichmond | L78-81 | 18-10 | .643 | - | | Robins Center · Richmond, VA |
| 29 | Sat Feb 25 | vsLoyola Chicago | W81-62 | 19-10 | .655 | - | CBS | Chaifetz Arena · St. Louis, MO |
| 30 | Tue Feb 28 | atVCU | L67-79 | 19-11 | .633 | - | CBS | Stuart C. Siegel Center · Richmond, VA |
| 31 | Fri Mar 3 | vsDayton | W65-61 | 20-11 | .645 | - | ESPN2 | Chaifetz Arena · St. Louis, MO |
| 32 | Thu Mar 9 | vsGeorge Mason | W82-54 | 21-11 | .656 | - | USA Net | Chaifetz Arena · St. Louis, MO |
| 33 | Sat Mar 11 | atVCU | L78-90 | 21-12 | .636 | - | CBS | Stuart C. Siegel Center · Richmond, VA |
