| 1 | Mon Nov 3 | vs N Arizona | W77-71 | 1-0 | 1.000 | - | YouTube | The Knapp Center · Des Moines, IA |
| 2 | Thu Nov 6 | vsRobert Morris | L79-81 (OT) | 1-1 | .500 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 3 | Mon Nov 10 | vsTBD | W89-51 | 2-1 | .667 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 4 | Fri Nov 14 | vsSIUE | L59-61 | 2-2 | .500 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 5 | Mon Nov 17 | atCharleston | W71-62 | 3-2 | .600 | - | | TD Arena · Charleston, SC |
| 6 | Fri Nov 21 | vsTBD | W98-52 | 4-2 | .667 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 7 | Fri Nov 28 | vsLSU | L62-71 | 4-3 | .571 | - | CBSSN | The Knapp Center · Des Moines, IA |
| 8 | Sat Nov 29 | vsGeorgia Tech | W84-74 | 5-3 | .625 | - | | The Knapp Center · Des Moines, IA |
| 9 | Tue Dec 2 | vsW Illinois | W108-57 | 6-3 | .667 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 10 | Fri Dec 5 | vsUAB | L69-74 | 6-4 | .600 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 11 | Sat Dec 13 | vsN Dakota St | L94-99 | 6-5 | .545 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 12 | Thu Dec 18 | atMurray St | L72-81 | 6-6 | .500 | - | ESPN+ | CFSB Center · Murray, KY |
| 13 | Sun Dec 21 | atEvansville | W66-65 | 7-6 | .538 | - | ESPN+ | Ford Center · Evansville, IN |
| 14 | Mon Dec 29 | vsIllinois St | L56-73 | 7-7 | .500 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 15 | Sun Jan 4 | vsIndiana St | W74-72 | 8-7 | .533 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 16 | Wed Jan 7 | atBradley | L66-93 | 8-8 | .500 | - | ESPN+ | Carver Arena · Peoria, IL |
| 17 | Sat Jan 10 | vsBelmont | L76-78 | 8-9 | .471 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 18 | Wed Jan 14 | atS Illinois | W76-73 (OT) | 9-9 | .500 | - | ESPN+ | Banterra Center · Carbondale, IL |
| 19 | Sat Jan 17 | atUIC | L67-74 | 9-10 | .474 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 20 | Wed Jan 21 | vsMurray St | W101-90 | 10-10 | .500 | - | CBSSN | The Knapp Center · Des Moines, IA |
| 21 | Sat Jan 24 | atIndiana St | W76-62 | 11-10 | .524 | - | ESPN+ | Hulman Center · Terre Haute, IN |
| 22 | Wed Jan 28 | vsEvansville | W82-78 | 12-10 | .545 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 23 | Sat Jan 31 | vsBradley | L73-87 | 12-11 | .522 | - | CBSSN | The Knapp Center · Des Moines, IA |
| 24 | Tue Feb 3 | atBelmont | L90-103 | 12-12 | .500 | - | ESPN+ | Curb Event Center Arena · Nashville, TN |
| 25 | Fri Feb 6 | atIllinois St | L76-86 | 12-13 | .480 | - | ESPN+ | Redbird Arena · Normal, IL |
| 26 | Mon Feb 9 | vsValparaiso | L76-81 | 12-14 | .462 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 27 | Thu Feb 12 | vsUIC | L70-80 | 12-15 | .444 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 28 | Sun Feb 15 | atNorthern Iowa | L62-86 | 12-16 | .429 | - | CBSSN | McLeod Center · Cedar Falls, IA |
| 29 | Wed Feb 18 | vsS Illinois | L61-66 | 12-17 | .414 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 30 | Wed Feb 25 | atValparaiso | L71-74 | 12-18 | .400 | - | ESPN+ | Athletics-Recreation Center · Valparaiso, IN |
| 31 | Sun Mar 1 | vsNorthern Iowa | L53-75 | 12-19 | .387 | - | ESPN+ | The Knapp Center · Des Moines, IA |
