| 1 | Mon Nov 4 | vs TBD | W93-41 | 1-0 | 1.000 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 2 | Sun Nov 10 | vs SF Austin | W66-51 | 2-0 | 1.000 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 3 | Sat Nov 16 | vs FGCU | W63-61 | 3-0 | 1.000 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 4 | Thu Nov 21 | vs Miami | W80-69 | 4-0 | 1.000 | - | ESPN2 | The Knapp Center · Des Moines, IA |
| 5 | Fri Nov 22 | at FAU | W75-63 | 5-0 | 1.000 | - | ESPN2 | FAU Arena · Boca Raton, FL |
| 6 | Sun Nov 24 | at Vanderbilt | W81-70 | 6-0 | 1.000 | - | ESPN | Memorial Gymnasium (TN) · Nashville, TN |
| 7 | Sat Nov 30 | vs Georgia So | W61-47 | 7-0 | 1.000 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 8 | Thu Dec 5 | at Valparaiso | W66-60 | 8-0 | 1.000 | - | ESPN+ | Athletics-Recreation Center · Valparaiso, IN |
| 9 | Thu Dec 12 | vsTBD | W90-35 | 9-0 | 1.000 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 10 | Tue Dec 17 | at Kansas St | W73-70 (OT) | 10-0 | 1.000 | - | ESPN+ | Bramlage Coliseum · Manhattan, KS |
| 11 | Sat Dec 21 | vs Green Bay | W72-62 | 11-0 | 1.000 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 12 | Sun Dec 29 | vs Belmont | W65-46 | 12-0 | 1.000 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 13 | Wed Jan 1 | at UIC | L70-74 | 12-1 | .923 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 14 | Sun Jan 5 | vs Murray St | L59-66 | 12-2 | .857 | - | ESPN2 | The Knapp Center · Des Moines, IA |
| 15 | Wed Jan 8 | at Bradley | W64-57 | 13-2 | .867 | - | CBS | Carver Arena · Peoria, IL |
| 16 | Sat Jan 11 | vs Evansville | W63-40 | 14-2 | .875 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 17 | Wed Jan 15 | vs Illinois St | W66-62 | 15-2 | .882 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 18 | Sat Jan 18 | at Indiana St | W71-53 | 16-2 | .889 | - | ESPNU | Hulman Center · Terre Haute, IN |
| 19 | Wed Jan 22 | vsValparaiso | W81-71 | 17-2 | .895 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 20 | Sat Jan 25 | at Missouri St | W69-62 (OT) | 18-2 | .900 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 21 | Wed Jan 29 | vs Northern Iowa | W66-52 | 19-2 | .905 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 22 | Sat Feb 1 | at S Illinois | W75-65 | 20-2 | .909 | - | ESPNU | Banterra Center · Carbondale, IL |
| 23 | Tue Feb 4 | atMurray St | W55-45 | 21-2 | .913 | - | ESPN2 | CFSB Center · Murray, KY |
| 24 | Sat Feb 8 | vsIndiana St | W85-81 (OT) | 22-2 | .917 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 25 | Wed Feb 12 | atIllinois St | W84-77 | 23-2 | .920 | - | ESPN+ | Redbird Arena · Normal, IL |
| 26 | Sun Feb 16 | vsBradley | L59-61 | 23-3 | .885 | - | ESPN2 | The Knapp Center · Des Moines, IA |
| 27 | Wed Feb 19 | vsUIC | W74-57 | 24-3 | .889 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 28 | Sun Feb 23 | atNorthern Iowa | W64-58 (OT) | 25-3 | .893 | - | ESPN2 | McLeod Center · Cedar Falls, IA |
| 29 | Wed Feb 26 | atEvansville | W65-61 | 26-3 | .897 | - | ESPN+ | Ford Center · Evansville, IN |
| 30 | Sun Mar 2 | vsMissouri St | W68-60 (OT) | 27-3 | .900 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 31 | Fri Mar 7 | vsS Illinois | W70-53 | 28-3 | .903 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 32 | Sat Mar 8 | vsBelmont | W57-50 | 29-3 | .906 | - | CBS | The Knapp Center · Des Moines, IA |
| 33 | Sun Mar 9 | vsBradley | W63-48 | 30-3 | .909 | - | CBS | The Knapp Center · Des Moines, IA |
| 34 | Thu Mar 20 | at #6Missouri | W67-57 | 31-3 | .912 | #11 | truTV | Mizzou Arena · Columbia, MO |
| 35 | Sat Mar 22 | at #3Texas Tech | L64-77 | 31-4 | .886 | #11 | TNT | United Supermarkets Arena · Lubbock, TX |
