| 1 | Mon Nov 4 | vs Southern | W93-79 | 1-0 | 1.000 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 2 | Wed Nov 6 | vs E Texas A&M | W91-83 | 2-0 | 1.000 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 3 | Sun Nov 10 | vs TBD | W77-47 | 3-0 | 1.000 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 4 | Tue Nov 12 | at Iowa | L77-96 | 3-1 | .750 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 5 | Thu Nov 14 | vsTBD | W92-69 | 4-1 | .800 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 6 | Wed Nov 20 | at W Michigan | W80-76 | 5-1 | .833 | - | ESPN+ | University Arena (MI) · Kalamazoo, MI |
| 7 | Fri Nov 22 | at So Indiana | L83-92 | 5-2 | .714 | - | ESPN+ | Screaming Eagles Arena · Evansville, IN |
| 8 | Mon Nov 25 | vsTBD | W112-50 | 6-2 | .750 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 9 | Wed Nov 27 | at Nebraska | L79-96 | 6-3 | .667 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 10 | Wed Dec 4 | vs Idaho St | W94-80 | 7-3 | .700 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 11 | Sat Dec 7 | at N Arizona | L82-95 | 7-4 | .636 | - | ESPN+ | J. Lawrence Walkup Skydome · Flagstaff, AZ |
| 12 | Tue Dec 10 | vs Wyoming | W82-81 | 8-4 | .667 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 13 | Sat Dec 14 | vs W Illinois | W89-66 | 9-4 | .692 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 14 | Thu Dec 19 | at Utah Tech | L87-92 | 9-5 | .643 | - | ESPN+ | placeholder · sf, ca |
| 15 | Sat Dec 21 | at Santa Clara | L81-98 | 9-6 | .600 | - | ESPN+ | Leavey Center · Santa Clara, CA |
| 16 | Thu Jan 2 | at Kansas City | L54-68 | 9-7 | .563 | - | | Swinney Recreation Center · Kansas City, MO |
| 17 | Sat Jan 4 | vs Denver | W91-84 | 10-7 | .588 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 18 | Sat Jan 11 | at St Thomas (MN) | L104-119 | 10-8 | .556 | - | | Schoenecker Arena · Saint Paul, MN |
| 19 | Thu Jan 16 | vs Oral Roberts | W92-82 | 11-8 | .579 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 20 | Sat Jan 18 | vs N Dakota St | L77-103 | 11-9 | .550 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 21 | Thu Jan 23 | at North Dakota | W102-93 | 12-9 | .571 | - | | Betty Engelstad Sioux Center · Grand Forks, ND |
| 22 | Sat Jan 25 | at S Dakota St | L71-90 | 12-10 | .545 | - | | Frost Arena · Brookings, SD |
| 23 | Wed Jan 29 | vs Omaha | W91-87 | 13-10 | .565 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 24 | Thu Feb 6 | atDenver | W86-79 | 14-10 | .583 | - | | Hamilton Gymnasium · Denver, CO |
| 25 | Sat Feb 8 | atOral Roberts | W75-74 | 15-10 | .600 | - | | Mabee Center · Tulsa, OK |
| 26 | Thu Feb 13 | vsKansas City | W79-72 | 16-10 | .615 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 27 | Sun Feb 16 | vsS Dakota St | L91-94 | 16-11 | .593 | - | CBS | Sanford Coyote Sports Center · Vermillion, SD |
| 28 | Wed Feb 19 | vsSt Thomas (MN) | W85-80 | 17-11 | .607 | - | | Sanford Coyote Sports Center · Vermillion, SD |
